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WAVE2 (human)

Overview WAVE2 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Actin binding protein; Motility/polarity/chemotaxis Cellular Component: ruffle; lamellipodium; early endosome; intracellular; actin cytoskeleton Molecular Function: protein binding; actin binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; lamellipodium biogenesis; actin filament-based movement; ameboidal cell migration; Rac protein signal transduction; endocytosis; angiogenesis; actin cytoskeleton organization and biogenesis Reference #:  Q9Y6W5 (UniProtKB) Alt. Names/Synonyms: dJ393P12.2; IMD2; Protein WAVE-2; SCAR2; suppressor of cyclic-AMP receptor (WASP-family); Verprolin homology domain-containing protein 2; WAS protein family, member 2; WASF2; WASP family protein member 2; WASP family Verprolin-homologous protein 2; WAVE2; Wiskott-Aldrich syndrome protein family member 2 Gene Symbols: WASF2 Molecular weight: 54,284 Da Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WAVE2 2A40 - C/F=433-464 (human)

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	Sites Implicated In
cell motility, altered: S308‑p, S343‑p, T346‑p, S351‑p cytoskeletal reorganization: Y150‑p, S308‑p, S343‑p, T346‑p, S351‑p, S482‑p, S484‑p, S488‑p, S489‑p, S497‑p inhibition: S482‑p, S484‑p, S488‑p, S489‑p, S497‑p intracellular localization: Y150‑p molecular association, regulation: Y150‑p, S308‑p, S343‑p, T346‑p, S351‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T29	RSELECVTNITLANV
0	1		T32	LECVTNITLANVIRQ
0	1		T80-p	DRLQVKVtQLDPKEE
0	1		K85	KVtQLDPKEEEVSLQ
0	5		T129-p	ETYNTCDtPPPLNNL
1	0		T137	PPPLNNLTPyRDDGK
0	2		Y139-p	PLNNLTPyRDDGKEA
2	0		Y150-p	GKEALKFyTDPSyFF
0	5		Y155-p	KFyTDPSyFFDLWkE
0	3		K161-u	SyFFDLWkEKMLQDt
0	1		T168-p	kEKMLQDtKDIMKEK
0	2		K216-u	GQEFVESkEKLGTSG
0	2		Y230-p	GYPPTLVyQNGSIGC
0	1		S257-p	PQSDSASsPsPSFSE
0	1		S259-p	SDSASsPsPSFSEDN
0	1		S284-p	PVDNQRGsGLAGPKR
0	1		S292-p	GLAGPKRssVVsPsH
0	2		S293-p	LAGPKRssVVsPsHP
1	3		S296-p	PKRssVVsPsHPPPA
0	1		S298-p	RssVVsPsHPPPAPP
1	4		S308-p	PPAPPLGsPPGPKPG
1	0		S343-p	PPPVGFGsPGtPPPP
1	0		T346-p	VGFGsPGtPPPPsPP
1	0		S351-p	PGtPPPPsPPSFPPH
0	1		D411-ca	PPPFTGAdGQPAIPP
1	0		S482-p	RRIAVEYsDsEDDss
1	1		S484-p	IAVEYsDsEDDssEF
1	1		S488-p	YsDsEDDssEFDEDD
1	1		S489-p	sDsEDDssEFDEDDW
1	2		S497-p	EFDEDDWsD______

	mouse
T29-p	TSELECRtNItLANV
T32-p	LECRtNItLANVIRQ
T80	DRVQVKVTQLDPkEE
K85-u	KVTQLDPkEEEVSLQ
A129	ETYNSCDAPPPLNNL
S137	PPPLNNLSPYRDDGK
Y139	PLNNLSPYRDDGKEA
Y150-p	GKEALKFyTNPSyFF
Y155-p	KFyTNPSyFFDLWkE
K161-u	SyFFDLWkEKMLQDT
T168	kEKMLQDTKDIMKEK
K216-u	GQEFVESkERLGPSG
Y230	GYSSTLVYQNGSIGS
S257	PQSDSASSPSPSFSE
S259	SDSASSPSPSFSEDN
S284	PADNQRGSVLAGPKR
T292	VLAGPKRTSMVSPSH
S293	LAGPKRTSMVSPSHP
S296	PKRTSMVSPSHPPPA
S298	RTSMVSPSHPPPAPP
S308	PPAPPLSSPPGPKPG
S341	LPSMGFGSPGTPPPP
T344	MGFGSPGTPPPPSPP
S349	PGTPPPPSPPSFPPH
D408	PLPFSGADGQPAAPP
S481-p	RRIAVEYsDsEDDss
S483-p	IAVEYsDsEDDssEF
S487-p	YsDsEDDssEFDEDD
S488-p	sDsEDDssEFDEDDW
S496-p	EFDEDDWsD______

	rat
T29	TSELECRTNITLANV
T32	LECRTNITLANVIRQ
T80	DRVQVKVTQLDPKEE
K85	KVTQLDPKEEEVSLQ
A129	ETYNSCDAPPPLNNL
S137-p	PPPLNNLsPYRDDGK
Y139	PLNNLsPYRDDGKEA
Y150	GKEALKFYTNPSYFF
Y155	KFYTNPSYFFDLWKE
K161	SYFFDLWKEKMLQDT
T168	KEKMLQDTKDIMKEK
K216	GQEFVESKEKLGPSG
Y230	GYSPALVYQNGNFGS
S257	PQSDSASSPSPSFSD
S259	SDSASSPSPSFSDDN
S284	PADNQRGSVLAGPKR
T292	VLAGPKRTSMVSPSH
S293	LAGPKRTSMVSPSHP
S296	PKRTSMVSPSHPPPA
S298	RTSMVSPSHPPPAPP
S308	PPAPPLSSPPGPKPG
S341	LPSVGFGSPGTPPPP
T344	VGFGSPGTPPPPSPP
S349	PGTPPPPSPPSFPPH
D408	PLPLGGADGQPAAPP
S481	RRIAVEYSDSEDDSS
S483	IAVEYSDSEDDSSEF
S487	YSDSEDDSSEFDEDD
S488	SDSEDDSSEFDEDDW
S496	EFDEDDWSD______

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