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Protein Page:
WAVE2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WAVE2 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Cellular Component: ruffle; lamellipodium; early endosome; intracellular; cytosol; actin cytoskeleton
Molecular Function: protein binding; protein complex binding; actin binding
Biological Process: lamellipodium biogenesis; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of stress fiber formation; actin filament-based movement; ameboidal cell migration; innate immune response; Rac protein signal transduction; angiogenesis; actin cytoskeleton organization and biogenesis
Reference #:  Q9Y6W5 (UniProtKB)
Alt. Names/Synonyms: dJ393P12.2; IMD2; Protein WAVE-2; SCAR2; suppressor of cyclic-AMP receptor (WASP-family); Verprolin homology domain-containing protein 2; WAS protein family, member 2; WASF2; WASP family protein member 2; WASP family Verprolin-homologous protein 2; WAVE2; Wiskott-Aldrich syndrome protein family member 2
Gene Symbols: WASF2
Molecular weight: 54,284 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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WAVE2

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S308‑p, S343‑p, T346‑p, S351‑p
cytoskeletal reorganization: Y150‑p, S308‑p, S343‑p, T346‑p, S351‑p, S482‑p, S484‑p, S488‑p, S489‑p, S497‑p
activity, inhibited: S482‑p, S484‑p, S488‑p, S489‑p, S497‑p
intracellular localization: Y150‑p
molecular association, regulation: Y150‑p, S308‑p, S343‑p, T346‑p, S351‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T29 RSELECVTNITLANV
0 1 T32 LECVTNITLANVIRQ
0 1 Y46-p QLGSLSKyAEDIFGE
0 1 T80-p DRLQVKVtQLDPKEE
0 1 K85 KVtQLDPKEEEVSLQ
0 5 T129-p ETYNTCDtPPPLNNL
2 0 T137 PPPLNNLTPyRDDGK
0 2 Y139-p PLNNLTPyRDDGKEA
3 0 Y150-p GKEALKFyTDPSyFF
0 5 Y155-p KFyTDPSyFFDLWkE
0 3 K161-ub SyFFDLWkEKMLQDt
0 1 T168-p kEKMLQDtKDIMKEK
0 2 K216-ub GQEFVESkEKLGTSG
0 1 Y230-p GYPPTLVyQNGSIGC
0 1 S257-p PQSDSASsPsPSFSE
0 1 S259-p SDSASsPsPSFSEDN
0 1 S284-p PVDNQRGsGLAGPKR
0 1 S292-p GLAGPKRssVVsPsH
0 3 S293-p LAGPKRssVVsPsHP
1 4 S296-p PKRssVVsPsHPPPA
0 1 S298-p RssVVsPsHPPPAPP
1 5 S308-p PPAPPLGsPPGPKPG
1 0 S343-p PPPVGFGsPGtPPPP
1 0 T346-p VGFGsPGtPPPPsPP
2 0 S351-p PGtPPPPsPPSFPPH
0 1 D411-ca PPPFTGAdGQPAIPP
0 1 S474-p NDVATILsRRIAVEY
1 0 S482-p RRIAVEYsDsEDDss
1 1 S484-p IAVEYsDsEDDssEF
1 1 S488-p YsDsEDDssEFDEDD
1 1 S489-p sDsEDDssEFDEDDW
1 2 S497-p EFDEDDWsD______
  mouse

 
T29-p TSELECRtNItLANV
T32-p LECRtNItLANVIRQ
Y46 QLGSLSKYAEDIFGE
T80 DRVQVKVTQLDPkEE
K85-ub KVTQLDPkEEEVSLQ
A129 ETYNSCDAPPPLNNL
S137-p PPPLNNLsPYRDDGK
Y139 PLNNLsPYRDDGKEA
Y150-p GKEALKFyTNPSyFF
Y155-p KFyTNPSyFFDLWkE
K161-ub SyFFDLWkEKMLQDT
T168 kEKMLQDTKDIMKEK
K216-ub GQEFVESkERLGPSG
Y230 GYSSTLVYQNGSIGS
S257 PQSDSASSPSPSFSE
S259 SDSASSPSPSFSEDN
S284 PADNQRGSVLAGPKR
T292 VLAGPKRTSMVSPSH
S293 LAGPKRTSMVSPSHP
S296 PKRTSMVSPSHPPPA
S298 RTSMVSPSHPPPAPP
S308 PPAPPLSSPPGPKPG
S341 LPSMGFGSPGTPPPP
T344 MGFGSPGTPPPPSPP
S349 PGTPPPPSPPSFPPH
D408 PLPFSGADGQPAAPP
S473 NDVATILSRRIAVEY
S481-p RRIAVEYsDsEDDss
S483-p IAVEYsDsEDDssEF
S487-p YsDsEDDssEFDEDD
S488-p sDsEDDssEFDEDDW
S496-p EFDEDDWsD______
  rat

 
T29 TSELECRTNITLANV
T32 LECRTNITLANVIRQ
Y46 QLGSLSKYAEDIFGE
T80 DRVQVKVTQLDPKEE
K85 KVTQLDPKEEEVSLQ
A129 ETYNSCDAPPPLNNL
S137-p PPPLNNLsPYRDDGK
Y139 PLNNLsPYRDDGKEA
Y150 GKEALKFYTNPSYFF
Y155 KFYTNPSYFFDLWKE
K161 SYFFDLWKEKMLQDT
T168 KEKMLQDTKDIMKEK
K216 GQEFVESKEKLGPSG
Y230 GYSPALVYQNGNFGS
S257 PQSDSASSPSPSFSD
S259 SDSASSPSPSFSDDN
S284 PADNQRGSVLAGPKR
T292 VLAGPKRTSMVSPSH
S293 LAGPKRTSMVSPSHP
S296 PKRTSMVSPSHPPPA
S298 RTSMVSPSHPPPAPP
S308 PPAPPLSSPPGPKPG
S341 LPSVGFGSPGTPPPP
T344 VGFGSPGTPPPPSPP
S349 PGTPPPPSPPSFPPH
D408 PLPLGGADGQPAAPP
S473 NDVATILSRRIAVEY
S481 RRIAVEYSDSEDDSS
S483 IAVEYSDSEDDSSEF
S487 YSDSEDDSSEFDEDD
S488 SDSEDDSSEFDEDDW
S496 EFDEDDWSD______
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