a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; EC 22.214.171.124; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; MLK family; MLK subfamily
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; JUN kinase kinase kinase activity; protein homodimerization activity; bHLH transcription factor binding; transcription corepressor activity; ATP binding; protein kinase activity
Biological Process: positive regulation of JNK activity; smoothened signaling pathway; negative regulation of transcription factor activity; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; signal transduction; activation of JNK activity; peptidyl-serine phosphorylation; induction of apoptosis; JNK cascade; negative regulation of transcription, DNA-dependent; activation of JNKK activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.