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MLK2 (human)

Overview MLK2 a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; MLK family; MLK subfamily Cellular Component: cytoplasm Molecular Function: protein serine/threonine kinase activity; JUN kinase kinase kinase activity; protein homodimerization activity; bHLH transcription factor binding; transcription corepressor activity; ATP binding; protein kinase activity Biological Process: positive regulation of JNK activity; smoothened signaling pathway; negative regulation of transcription factor activity; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; signal transduction; activation of JNK activity; peptidyl-serine phosphorylation; induction of apoptosis; JNK cascade; negative regulation of transcription, DNA-dependent; activation of JNKK activity Reference #:  Q02779 (UniProtKB) Alt. Names/Synonyms: M3K10; MAP3K10; MEKK10; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK2; MST; Protein kinase MST Gene Symbols: MAP3K10 Molecular weight: 103,694 Da Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK

Select Structure to View Below MLK2 2RF0 - A/D/C/B=13-78 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S262	WHKTTKMSAAGTYAW
0	2		S446-p	HLLMCQLsQEKPRVR
0	2		S489-p	HKITVQAsPTLDKRK
0	4		S498-p	TLDKRKGsDGAsPPA
0	5		S502-p	RKGsDGAsPPAsPsI
0	3		S506-p	DGAsPPAsPsIIPRL
0	1		S508-p	AsPPAsPsIIPRLRA
0	1		T519	RLRAIRLTPVDCGGS
0	1		S539	SGGSGTWSRGGPPKK
0	2		T558-p	GGKKKGRtWGPSSTL
0	3		S583	LKGLGEGSKQWSSsA
0	3		S589-p	GSKQWSSsAPNLGKS
0	1		S596	sAPNLGKSPKHTPIA
0	1		G683	LGCATLLGAVGLGAD
0	1		S809-p	FKKDPRQsLTPTHVT
0	1		S830-p	RGHRRTPsDGALGQR

	mouse
S262-p	WHKTTKMsAAGTYAW
S446-p	HLLMSQLsQEKPRVR
S489	HKITVQASPTLDKRK
S498-p	TLDKRKGsDGAsPPA
S502-p	RKGsDGAsPPAsPSI
S506-p	DGAsPPAsPSIIPRL
S508	AsPPAsPSIIPRLRA
T519-p	RLRAIRLtPMDCGGS
S533-p	SSGSGTWsRSGPPKK
T552-p	GGKKKGRtWGPSSTL
S577-p	LKALGEGsKQWSSsA
S583-p	GsKQWSSsAPNLGKs
S590-p	sAPNLGKsPKHTPMA
S675	LSCATLLSAVGLGAD
S797	FKKDPRQSLTPTHVT
S818	RGHRRTPSDGALRQR

	rat
S262	WHKTTKMSAAGTYAW
S446-p	HLLMSQLsQEKPRVR
S489	HKITVQASPTLDKRK
S498	TLDKRKGSDGASPPA
S502	RKGSDGASPPASPSI
S506	DGASPPASPSIIPRL
S508	ASPPASPSIIPRLRA
T519	RLRAIRLTPVDCGSS
S533	SGGSGTWSRSGPPKK
T552	GGKKKGRTWGPSSTL
S577	LKALGEGSKQWSSSA
S583	GSKQWSSSAPNLGKS
S590	SAPNLGKSPKHTPMA
S675-p	LGCATLLsAVGLGAD
S797	FKKDPRQSLTPTHVT
S818	RGHRRTPSDGALRQR

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