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Protein Page:
CNP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CNP May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Phosphodiesterase; EC 3.1.4.37
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: microtubule; extracellular space; microvillus; pseudopodium; nucleoplasm; mitochondrial outer membrane; membrane; perinuclear region of cytoplasm; cytoplasm; mitochondrial inner membrane; melanosome; plasma membrane; nucleus
Molecular Function: cyclic nucleotide binding; RNA binding; 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Biological Process: synaptic transmission; substantia nigra development; axonogenesis; adult locomotory behavior; response to toxin; forebrain development; oligodendrocyte differentiation; response to lipopolysaccharide; microtubule cytoskeleton organization and biogenesis; regulation of mitochondrial membrane permeability; cyclic nucleotide catabolic process; aging
Reference #:  P09543 (UniProtKB)
Alt. Names/Synonyms: 2', 3' cyclic nucleotide 3' phosphohydrolase; 2',3'-cyclic nucleotide 3' phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CN37; CNP; CNP1; CNPase
Gene Symbols: CNP
Molecular weight: 47,579 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CNP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 G4 ____MNRGFsRKsHt
0 3 S6-p __MNRGFsRKsHtFL
1 8 S9-p NRGFsRKsHtFLPkI
0 3 T11-p GFsRKsHtFLPkIFF
0 1 K15 KsHtFLPKIFFRKMs
0 2 K15-ub KsHtFLPkIFFRKMs
1 8 S22-p kIFFRKMsSsGAKDk
0 2 S24-p FFRKMsSsGAKDkPE
1 1 K27 KMsSsGAKDkPELQF
1 1 K27 KMsSsGAKDkPELQF
0 1 K27 KMsSsGAKDkPELQF
0 1 K29 sSsGAKDKPELQFPF
1 1 K29 sSsGAKDKPELQFPF
0 2 K29-ub sSsGAKDkPELQFPF
0 7 K63 RGLPGSGKSTLARVI
0 1 K73 LARVIVDKYRDGTKM
1 0 K73 LARVIVDKYRDGTKM
0 3 K73-ub LARVIVDkYRDGTKM
1 0 K79 DkYRDGTKMVSADAy
0 1 K79 DkYRDGTKMVSADAy
0 4 Y86-p KMVSADAykITPGAR
0 1 K87 MVSADAyKITPGARG
0 27 K87-ub MVSADAykITPGARG
0 1 S97 PGARGAFSEEykRLD
0 4 Y100-p RGAFSEEykRLDEDL
0 2 K101 GAFSEEyKRLDEDLA
0 10 K101-ub GAFSEEykRLDEDLA
1 148 Y110-p LDEDLAAyCRRRDIR
0 1 Y141-p LFEMADQyQYQVVLV
0 1 K162 RLDCAQLKEKNQWQL
0 20 K162 RLDCAQLKEKNQWQL
0 1 K164 DCAQLKEKNQWQLsA
0 1 K164 DCAQLKEKNQWQLsA
1 28 S170-p EKNQWQLsADDLkKL
0 10 K175-ac QLsADDLkKLKPGLE
0 10 K175 QLsADDLKKLKPGLE
0 1 K175-sc QLsADDLkKLKPGLE
0 10 K176 LsADDLkKLKPGLEK
0 4 K178 ADDLkKLKPGLEKDF
0 1 K196 YFGWFLTKKSSETLR
0 1 K204 KSSETLRKAGQVFLE
0 3 K217 LEELGNHKAFkKELR
0 11 K217-ub LEELGNHkAFkKELR
0 1 K217-sc LEELGNHkAFkKELR
0 2 K220-ub LGNHkAFkKELRQFV
0 1 K221 GNHkAFkKELRQFVP
0 1 K221 GNHkAFkKELRQFVP
0 2 P228 KELRQFVPGDEPREK
0 2 R233 FVPGDEPREKMDLVT
0 3 R233 FVPGDEPREKMDLVT
0 1 K235 PGDEPREKMDLVTYF
0 2 K235 PGDEPREKMDLVTYF
0 3 T240 REKMDLVTYFGKRPP
0 1 K244 DLVTYFGKRPPGVLH
0 3 K255 GVLHCTTKFCDYGKA
0 3 K255 GVLHCTTKFCDYGKA
0 1 K261 TKFCDYGKAPGAEEY
0 21 K261 TKFCDYGKAPGAEEY
0 1 P263 FCDYGKAPGAEEYAQ
0 1 Y268 KAPGAEEYAQQDVLK
0 3 K275 YAQQDVLKKSYSKAF
0 2 K275 YAQQDVLKKSYSKAF
0 3 K280 VLKKSYSKAFTLTIS
0 1 T285 YSKAFTLTISALFVt
0 1 S287 KAFTLTISALFVtPK
0 1 T292-p TISALFVtPKTTGAR
0 1 S312-p QQLQLWPsDVDkLsP
0 1 K316 LWPsDVDKLsPTDNL
0 16 K316-ub LWPsDVDkLsPTDNL
0 2 S318-p PsDVDkLsPTDNLPR
0 5 K356 LEILRQEKGGSRGEE
0 1 S359 LRQEKGGSRGEEVGE
0 1 K371 VGELSRGKLySLGNG
0 3 K371 VGELSRGKLySLGNG
0 64 Y373-p ELSRGKLySLGNGRW
0 4 S374 LSRGKLySLGNGRWM
0 4 N377 GKLySLGNGRWMLtL
0 10 N377 GKLySLGNGRWMLtL
0 4 T383-p GNGRWMLtLAKNMEV
1 1 K386 RWMLtLAKNMEVRAI
0 1 K386 RWMLtLAKNMEVRAI
0 5 K400 IFTGYYGKGKPVPtQ
0 4 K402 TGYYGKGKPVPtQGs
0 1 T406-p GKGKPVPtQGsRKGG
0 4 S409-p KPVPtQGsRKGGALQ
  CNP iso2  
- gap
- gap
- gap
- gap
- gap
- gap
S2 ______MSSSGAKDK
S4 ____MSSSGAKDKPE
K7 _MSSSGAKDKPELQF
K7 _MSSSGAKDKPELQF
K7 _MSSSGAKDKPELQF
K9 SSSGAKDKPELQFPF
K9 SSSGAKDKPELQFPF
K9 SSSGAKDKPELQFPF
K43 RGLPGSGKSTLARVI
K53 LARVIVDKYRDGTKM
K53 LARVIVDKYRDGTKM
K53 LARVIVDKYRDGTKM
K59 DKYRDGTKMVSADAY
K59 DKYRDGTKMVSADAY
Y66 KMVSADAYKITPGAR
K67 MVSADAYKITPGARG
K67 MVSADAYKITPGARG
S77 PGARGAFSEEYKRLD
Y80 RGAFSEEYKRLDEDL
K81 GAFSEEYKRLDEDLA
K81 GAFSEEYKRLDEDLA
Y90 LDEDLAAYCRRRDIR
Y121 LFEMADQYQYQVVLV
K142 RLDCAQLKEKNQWQL
K142 RLDCAQLKEKNQWQL
K144 DCAQLKEKNQWQLSA
K144 DCAQLKEKNQWQLSA
S150 EKNQWQLSADDLKKL
K155 QLSADDLKKLKPGLE
K155 QLSADDLKKLKPGLE
K155 QLSADDLKKLKPGLE
K156 LSADDLKKLKPGLEK
K158 ADDLKKLKPGLEKDF
K176 YFGWFLTKKSSETLR
K184 KSSETLRKAGQVFLE
K197 LEELGNHKAFKKELR
K197 LEELGNHKAFKKELR
K197 LEELGNHKAFKKELR
K200 LGNHKAFKKELRQFV
K201 GNHKAFKKELRQFVP
K201 GNHKAFKKELRQFVP
P208 KELRQFVPGDEPREK
R213 FVPGDEPREKMDLVT
R213 FVPGDEPREKMDLVT
K215 PGDEPREKMDLVTYF
K215 PGDEPREKMDLVTYF
T220 REKMDLVTYFGKRPP
K224 DLVTYFGKRPPGVLH
K235 GVLHCTTKFCDYGKA
K235 GVLHCTTKFCDYGKA
K241 TKFCDYGKAPGAEEY
K241 TKFCDYGKAPGAEEY
P243 FCDYGKAPGAEEYAQ
Y248 KAPGAEEYAQQDVLK
K255 YAQQDVLKKSYSKAF
K255 YAQQDVLKKSYSKAF
K260 VLKKSYSKAFTLTIS
T265 YSKAFTLTISALFVT
S267 KAFTLTISALFVTPK
T272 TISALFVTPKTTGAR
S292 QQLQLWPSDVDKLSP
K296 LWPSDVDKLSPTDNL
K296 LWPSDVDKLSPTDNL
S298 PSDVDKLSPTDNLPR
K336 LEILRQEKGGSRGEE
S339 LRQEKGGSRGEEVGE
K351 VGELSRGKLYSLGNG
K351 VGELSRGKLYSLGNG
Y353 ELSRGKLYSLGNGRW
S354 LSRGKLYSLGNGRWM
N357 GKLYSLGNGRWMLTL
N357 GKLYSLGNGRWMLTL
T363 GNGRWMLTLAKNMEV
K366 RWMLTLAKNMEVRAI
K366 RWMLTLAKNMEVRAI
K380 IFTGYYGKGKPVPTQ
K382 TGYYGKGKPVPTQGS
T386 GKGKPVPTQGSRKGG
S389 KPVPTQGSRKGGALQ
  mouse

 
S4-p ____MNTsFTRKsHT
T6 __MNTsFTRKsHTFL
S9-p NTsFTRKsHTFLPkL
T11 sFTRKsHTFLPkLFF
K15 KsHTFLPKLFFRKMs
K15-ub KsHTFLPkLFFRKMs
S22-p kLFFRKMsSSGAkEK
S24 FFRKMsSSGAkEKPE
K27 KMsSSGAKEKPELQF
K27 KMsSSGAKEKPELQF
K27-ub KMsSSGAkEKPELQF
K29 sSSGAkEKPELQFPF
K29 sSSGAkEKPELQFPF
K29 sSSGAkEKPELQFPF
K63-ub RGLPGSGkSTLARLI
K73 LARLILEKYHDGTkM
K73 LARLILEKYHDGTkM
K73-ub LARLILEkYHDGTkM
K79 EkYHDGTKMVSADAY
K79-ub EkYHDGTkMVSADAY
Y86 kMVSADAYkIIPGSR
K87 MVSADAYKIIPGSRA
K87-ub MVSADAYkIIPGSRA
S97 PGSRADFSEAYkRLD
Y100 RADFSEAYkRLDEDL
K101-ac ADFSEAYkRLDEDLA
K101-ub ADFSEAYkRLDEDLA
Y110-p LDEDLAGyCRRDIRV
Y140 LFEMADQYQYQVVLV
K161 RLDCAQLKEkNQWQL
K161-ub RLDCAQLkEkNQWQL
K163 DCAQLkEKNQWQLsA
K163-ub DCAQLkEkNQWQLsA
S169-p EkNQWQLsADDLkkL
K174-ac QLsADDLkkLkPGLE
K174-ub QLsADDLkkLkPGLE
K174 QLsADDLKkLkPGLE
K175-ub LsADDLkkLkPGLEK
K177-ac ADDLkkLkPGLEKDF
K195-ac YFGWFLTkKSSETLR
K203-ub KSSETLRkAGQVFLE
K216 LEELGNHKAFkKELR
K216-ub LEELGNHkAFkKELR
K216 LEELGNHKAFkKELR
K219-ub LGNHkAFkKELRHFI
K220 GNHkAFkKELRHFIs
K220 GNHkAFkKELRHFIs
S227-p KELRHFIsGDEPkEk
K232 FIsGDEPKEkLELVs
K232-ub FIsGDEPkEkLELVs
K234 sGDEPkEKLELVsYF
K234-ub sGDEPkEkLELVsYF
S239-p kEkLELVsYFGKRPP
K243 ELVsYFGKRPPGVLH
K254 GVLHCTTKFCDYGkA
K254-ub GVLHCTTkFCDYGkA
K260 TkFCDYGKAAGAEEy
K260-ub TkFCDYGkAAGAEEy
A262 FCDYGkAAGAEEyAQ
Y267-p kAAGAEEyAQQEVVk
K274-ub yAQQEVVkRSYGKAF
K274-ac yAQQEVVkRSYGKAF
K279 VVkRSYGKAFKLsIs
S284-p YGKAFKLsIsALFVT
S286-p KAFKLsIsALFVTPK
T291 sIsALFVTPKTAGAQ
S311 QELQLWPSDLDkPSA
K315 LWPSDLDKPSASEGL
K315-ub LWPSDLDkPSASEGL
S317 PSDLDkPSASEGLPP
K355-ub LDILQQVkGGSQGEA
S358 LQQVkGGSQGEAVGE
K370 VGELPRGKLysLGkG
K370-ub VGELPRGkLysLGkG
Y372-p ELPRGkLysLGkGRW
S373-p LPRGkLysLGkGRWM
K376-ac GkLysLGkGRWMLsL
K376-ub GkLysLGkGRWMLsL
S382-p GkGRWMLsLTkKMEV
K385 RWMLsLTKKMEVKAI
K385-ub RWMLsLTkKMEVKAI
K399-ac IFTGYYGkGkPVPIH
K401-ub TGYYGkGkPVPIHGs
I405 GkGkPVPIHGsRKGG
S408-p kPVPIHGsRKGGAMQ
  rat

 
S4 ____MSTSFARKsHT
A6 __MSTSFARKsHTFL
S9-p STSFARKsHTFLPkI
T11 SFARKsHTFLPkIFF
K15-ac KsHTFLPkIFFRKMs
K15 KsHTFLPKIFFRKMs
S22-p kIFFRKMsSSGAkDk
S24 FFRKMsSSGAkDkPE
K27-m2 KMsSSGAkDkPELQF
K27-m3 KMsSSGAkDkPELQF
K27 KMsSSGAKDkPELQF
K29-ac sSSGAkDkPELQFPF
K29-m2 sSSGAkDkPELQFPF
K29-ub sSSGAkDkPELQFPF
K63 RGLPGSGKSTLARLI
K73-ac LARLIVEkYHNGTkM
K73-me LARLIVEkYHNGTkM
K73 LARLIVEKYHNGTkM
K79-me EkYHNGTkMVSADAy
K79 EkYHNGTKMVSADAy
Y86-p kMVSADAykIIPGSR
K87-ac MVSADAykIIPGSRA
K87-ub MVSADAykIIPGSRA
S97-p PGSRADFsEEYkRLD
Y100 RADFsEEYkRLDEDL
K101-ac ADFsEEYkRLDEDLA
K101-ub ADFsEEYkRLDEDLA
Y110-p LDEDLAGyCRRDIRV
Y140 LFEMADQYQYQVVLV
K161-ac RLDCAQLkEkNQWQL
K161-ub RLDCAQLkEkNQWQL
K163-ac DCAQLkEkNQWQLsL
K163 DCAQLkEKNQWQLsL
S169-p EkNQWQLsLDDLkkL
K174-ac QLsLDDLkkLkPGLE
K174-ub QLsLDDLkkLkPGLE
K174 QLsLDDLKkLkPGLE
K175-ub LsLDDLkkLkPGLEK
K177-ac LDDLkkLkPGLEKDF
K195 YFGWFLTKKSSETLR
K203 KSSETLRKAGQVFLE
K216-ac LEELGNHkAFKkELR
K216-ub LEELGNHkAFKkELR
K216 LEELGNHKAFKkELR
K219 LGNHkAFKkELRHFI
K220-ac GNHkAFKkELRHFIs
K220-ub GNHkAFKkELRHFIs
S227-p kELRHFIsGDEPkEk
K232-ac FIsGDEPkEkLDLVs
K232-ub FIsGDEPkEkLDLVs
K234-ac sGDEPkEkLDLVsYF
K234-ub sGDEPkEkLDLVsYF
S239-p kEkLDLVsYFGkRPP
K243-ac DLVsYFGkRPPGVLH
K254-ac GVLHCTTkFCDYGkA
K254-ub GVLHCTTkFCDYGkA
K260-ac TkFCDYGkAtGAEEY
K260-ub TkFCDYGkAtGAEEY
T262-p FCDYGkAtGAEEYAQ
Y267 kAtGAEEYAQQDVVR
R274 YAQQDVVRRSYGkAF
R274 YAQQDVVRRSYGkAF
K279-ac VVRRSYGkAFKLSIS
S284 YGkAFKLSISALFVT
S286 kAFKLSISALFVTPK
T291 SISALFVTPKTAGAQ
S311 QELQLWPSDLDkPSS
K315-ac LWPSDLDkPSSSESL
K315-ub LWPSDLDkPSSSESL
S317 PSDLDkPSSSESLPP
K355-ub LEILQQVkGGsQGEE
S358-p LQQVkGGsQGEEVGE
K370-ac VGELPRGkLysLGkG
K370 VGELPRGKLysLGkG
Y372-p ELPRGkLysLGkGRW
S373-p LPRGkLysLGkGRWM
K376-ac GkLysLGkGRWMLsL
K376-ub GkLysLGkGRWMLsL
S382-p GkGRWMLsLAkKMEV
K385-ac RWMLsLAkKMEVKAI
K385 RWMLsLAKKMEVKAI
K399-ac IFTGYYGkGkPVPVH
K401-ub TGYYGkGkPVPVHGs
V405 GkGkPVPVHGsRKGG
S408-p kPVPVHGsRKGGAMQ
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