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MARK3 (human)

Overview MARK3 an ubiquitous serine/threonine kinase of the CAMKL family. Phosphorylates Cdc25C on serine 216 and promotes 14-3-3 protein binding. A positive regulator of Wnt signalling. Ubiquitously expressed in human tissues and cell lines. Seven alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; CAMKL family; MARK subfamily Cellular Component: plasma membrane Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding Reference #:  P27448 (UniProtKB) Alt. Names/Synonyms: C-TAK1; Cdc25C-associated protein kinase 1; CTAK1; ELKL motif kinase 2; EMK-2; EMK2; KP78; MAP/microtubule affinity-regulating kinase 3; MARK3; PAR1A; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine-protein kinase p78 Gene Symbols: MARK3 Molecular weight: 84,489 Da Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MARK3 2QNJ - A/B=47-370 (human) 3FE3 - A/B=41-367 (human) 1UL7 - A=657-753 (mouse) 1V5S - A=645-753 (mouse)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2QNJ 3FE3  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source MARK3 P78  |  InnateDB  |  UCSD-Nature  |  GeneCards MARK3 P78  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T211‑p, S215‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T3-p	_____MStRTPLPTV
0	4		S42-p	SGARCRNsIAsCADE
0	3		S45-p	RCRNsIAsCADEQPH
0	8		T61-p	GNYRLLKtIGKGNFA
1	0		T90	AIKIIDKTQLNPTSL
1	0		T95	DKTQLNPTSLQKLFR
1	0		S96	KTQLNPTSLQKLFRE
2	46		T211-p	TVGGKLDtFCGsPPY
2	15		S215-p	KLDtFCGsPPYAAPE
0	1		K294-u	FLVLNPIkRGTLEQI
0	1		K330-u	ELDISDQkRIDIMVG
0	1		Y340-p	DIMVGMGysQEEIQE
0	1		S341-p	IMVGMGysQEEIQES
0	1		S368	YLLLGRKSSELDAsD
0	5		S374-p	KSSELDAsDsssssN
0	1		S376-p	SELDAsDsssssNLs
0	2		S377-p	ELDAsDsssssNLsL
0	5		S378-p	LDAsDsssssNLsLA
0	4		S379-p	DAsDsssssNLsLAK
0	4		S380-p	AsDsssssNLsLAKV
0	4		S383-p	sssssNLsLAKVRPS
0	13		S391	LAKVRPSSDLNNStG
0	3		N394	VRPSSDLNNStGQsP
0	1		S396	PSSDLNNStGQsPHH
0	1		T397-p	SSDLNNStGQsPHHK
0	16		S400-p	LNNStGQsPHHKVQR
0	3		Y418-p	SSQKQRRysDHAGPA
0	15		S419-p	SQKQRRysDHAGPAI
0	2		Y432-p	AIPSVVAyPKRSQtS
0	6		T438-p	AyPKRSQtSTADSDL
0	1		S455-p	DGISSRKsSGSAVGG
0	1		S456	GISSRKsSGSAVGGK
0	14		S469-p	GKGIAPAsPMLGNAs
0	2		S476-p	sPMLGNAsNPNKADI
0	4		S489-p	DIPERKKsstVPsSN
0	7		S490-p	IPERKKsstVPsSNT
0	8		T491-p	PERKKsstVPsSNTA
0	2		S494-p	KKsstVPsSNTAsGG
0	3		S499-p	VPsSNTAsGGMtRRN
0	5		T503-p	NTAsGGMtRRNtyVC
1	269		T507-p	GGMtRRNtyVCsERT
0	32		Y508-p	GMtRRNtyVCsERTT
0	1		S511-p	RRNtyVCsERTTADR
0	1		S520	RTTADRHSVIQNGKE
0	2		T536-p	STIPDQRtPVAstHs
0	11		S540-p	DQRtPVAstHsIssA
0	6		T541-p	QRtPVAstHsIssAA
0	8		S543-p	tPVAstHsIssAAtP
0	1		S545-p	VAstHsIssAAtPDR
0	1		S546-p	AstHsIssAAtPDRI
0	7		T549-p	HsIssAAtPDRIRFP
1	1		T564-p	RGTASRStFHGQPRE
0	8		T576-p	PRERRTAtyNGPPAs
0	10		Y577-p	RERRTAtyNGPPAsP
0	11		S583-p	tyNGPPAsPsLsHEA
0	3		S585-p	NGPPAsPsLsHEAtP
0	3		S587-p	PPAsPsLsHEAtPLS
0	1		T591-p	PsLsHEAtPLSQTRs
1	1		S598-p	tPLSQTRsRGsTNLF
1	10		S601-p	SQTRsRGsTNLFSKL
1	0		T602	QTRsRGsTNLFSKLT
1	0		S606	RGsTNLFSKLTSKLT
0	1		S618-p	KLTRRNMsFRFIKRL
0	4		S643-p	EGSSRNVsAEQKDEN
0	5		S657-p	NKEAKPRsLRFTWSM
0	1		K681	DMMREIRKVLDANNC
0	12		Y690-p	LDANNCDyEQRERFL
0	2		K741-u	SGTSIAFkNIASKIA

	MARK3 iso3
T3	_____MSTRTPLPTV
S42-p	SGARCRNsIAsCADE
S45-p	RCRNsIAsCADEQPH
T61-p	GNYRLLKtIGKGNFA
T90-p	AIKIIDKtQLNPtsL
T95-p	DKtQLNPtsLQKLFR
S96-p	KtQLNPtsLQKLFRE
T211-p	TVGGKLDtFCGSPPY
S215	KLDtFCGSPPYAAPE
K294	FLVLNPIKRGTLEQI
K330	ELDISDQKRIDIMVG
Y340	DIMVGMGYSQEEIQE
S341	IMVGMGYSQEEIQES
S368	YLLLGRKSSELDASD
S374	KSSELDASDSSsSSN
S376	SELDASDSSsSSNLS
S377	ELDASDSSsSSNLSL
S378-p	LDASDSSsSSNLSLA
S379	DASDSSsSSNLSLAK
S380	ASDSSsSSNLSLAKV
S383	SSsSSNLSLAKVRPS
S391	LAKVRPSSDLNNsTG
N394	VRPSSDLNNsTGQsP
S396-p	PSSDLNNsTGQsPHH
T397	SSDLNNsTGQsPHHK
S400-p	LNNsTGQsPHHKVQR
Y418	SSQKQRRYsDHAGPA
S419-p	SQKQRRYsDHAGPAI
Y432	AIPSVVAYPKRSQTS
T438	AYPKRSQTSTADSDL
S455	DGISSRKSSGSAVGG
S456	GISSRKSSGSAVGGK
S469-p	GKGIAPAsPMLGNAS
S476	sPMLGNASNPNKADI
S489	DIPERKKSstVPSSN
S490-p	IPERKKSstVPSSNT
T491-p	PERKKSstVPSSNTA
S494	KKSstVPSSNTASGG
S499	VPSSNTASGGMTRRN
T503	NTASGGMTRRNtyVC
T507-p	GGMTRRNtyVCSERT
Y508-p	GMTRRNtyVCSERTT
S511	RRNtyVCSERTTADR
S520	RTTADRHSVIQNGKE
T536-p	STIPDQRtPVAStHs
S540	DQRtPVAStHsISSA
T541-p	QRtPVAStHsISSAA
S543-p	tPVAStHsISSAAtP
S545	VAStHsISSAAtPDR
S546	AStHsISSAAtPDRI
T549-p	HsISSAAtPDRIRFP
T564-p	RGTASRStFHGQPRE
T576-p	PRERRTAtYNGPPAs
Y577	RERRTAtYNGPPAsP
S583-p	tYNGPPAsPSLSHEA
S585	NGPPAsPSLSHEATP
S587	PPAsPSLSHEATPLS
T591	PSLSHEATPLSQTRs
S598-p	TPLSQTRsRGstNLF
S601-p	SQTRsRGstNLFsKL
T602-p	QTRsRGstNLFsKLT
S606-p	RGstNLFsKLTSKLT
-	gap
S619	LTRSRNVSAEQKDEN
S633	NKEAKPRSLRFTWSM
K657	DMMREIRKVLDANNC
Y666	LDANNCDYEQRERFL
K717	SGTSIAFKNIASKIA

	MARK3 iso6
T3	_____MSTRTPLPTV
S42	SGARCRNSIASCADE
S45	RCRNSIASCADEQPH
T61	GNYRLLKTIGKGNFA
T90	AIKIIDKTQLNPTSL
T95	DKTQLNPTSLQKLFR
S96	KTQLNPTSLQKLFRE
T211	TVGGKLDTFCGSPPY
S215	KLDTFCGSPPYAAPE
K294	FLVLNPIKRGTLEQI
K330	ELDISDQKRIDIMVG
Y340	DIMVGMGYSQEEIQE
S341	IMVGMGYSQEEIQES
S368	YLLLGRKSSEVRPSS
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S375	SSEVRPSSDLNNSTG
N378	VRPSSDLNNSTGQsP
S380	PSSDLNNSTGQsPHH
T381	SSDLNNSTGQsPHHK
S384-p	LNNSTGQsPHHKVQR
Y402	SSQKQRRYSDHAGPA
S403	SQKQRRYSDHAGPAI
Y416	AIPSVVAYPKRSQTS
T422	AYPKRSQTSTADSDL
S439	DGISSRKSSGSAVGG
S440	GISSRKSSGSAVGGK
S453	GKGIAPASPMLGNAS
S460	SPMLGNASNPNKADI
S473	DIPERKKSsTVPSSN
S474-p	IPERKKSsTVPSSNT
T475	PERKKSsTVPSSNTA
S478	KKSsTVPSSNTASGG
S483	VPSSNTASGGMTRRN
T487	NTASGGMTRRNtyVC
T491-p	GGMTRRNtyVCSERT
Y492-p	GMTRRNtyVCSERTT
S495	RRNtyVCSERTTADR
S504	RTTADRHSVIQNGKE
T520	STIPDQRTPVASTHS
S524	DQRTPVASTHSISSA
T525	QRTPVASTHSISSAA
S527	TPVASTHSISSAATP
S529	VASTHSISSAATPDR
S530	ASTHSISSAATPDRI
T533	HSISSAATPDRIRFP
T548	RGTASRSTFHGQPRE
T560	PRERRTATYNGPPAS
Y561	RERRTATYNGPPASP
S567	TYNGPPASPSLSHEA
S569	NGPPASPSLSHEATP
S571	PPASPSLSHEATPLS
T575	PSLSHEATPLSQTRS
S582	TPLSQTRSRGSTNLF
S585	SQTRSRGSTNLFSKL
T586	QTRSRGSTNLFSKLT
S590	RGSTNLFSKLTSKLT
-	gap
S603	LTRSRNVSAEQKDEN
S617	NKEAKPRSLRFTWSM
K641	DMMREIRKVLDANNC
Y650	LDANNCDYEQRERFL
K701	SGTSIAFKNIASKIA

	mouse
T3	_____MSTRTPLPTV
S42-p	SGARCRNsIAsCADE
S45-p	RCRNsIAsCADEQPH
T61-p	GNYRLLKtIGKGNFA
T90	AIKIIDKTQLNPTSL
T95	DKTQLNPTSLQKLFR
S96	KTQLNPTSLQKLFRE
T211-p	TVGSKLDtFCGsPPY
S215-p	KLDtFCGsPPYAAPE
K294	FLVLNPVKRGTLEQI
K330	ELDISDQKRIDIMVG
Y340	DIMVGMGYSQEEIQE
S341	IMVGMGYSQEEIQES
S368-p	YLLLGRKsAELDAsD
S374-p	KsAELDAsDsssssN
S376-p	AELDAsDsssssNLs
S377-p	ELDAsDsssssNLsL
S378-p	LDAsDsssssNLsLA
S379-p	DAsDsssssNLsLAK
S380-p	AsDsssssNLsLAKV
S383-p	sssssNLsLAKVRPN
S391-p	LAKVRPNsDLsNsTG
S394-p	VRPNsDLsNsTGQsP
S396-p	PNsDLsNsTGQsPHH
T397	NsDLsNsTGQsPHHK
S400-p	LsNsTGQsPHHKGQR
Y418-p	SSQKQRRysDHAGPA
S419-p	SQKQRRysDHAGPAI
Y432	AIPSVVAYPKRSQtS
T438-p	AYPKRSQtSTADSDL
S455	DGIPSRKSsSSAVGG
S456-p	GIPSRKSsSSAVGGK
S469-p	GKGIAPAsPMLGNAG
G476	sPMLGNAGNPNKADI
S489-p	DIPERKKsPAVPsSN
P490	IPERKKsPAVPsSNT
A491	PERKKsPAVPsSNTA
S494-p	KKsPAVPsSNTASGG
S499	VPsSNTASGGMtRRN
T503-p	NTASGGMtRRNtyVC
T507-p	GGMtRRNtyVCSERC
Y508-p	GMtRRNtyVCSERCA
S511	RRNtyVCSERCAADR
S520-p	RCAADRHsVIQNGKE
T536	SAIPDERTPVAstHs
S540-p	DERTPVAstHsISsA
T541-p	ERTPVAstHsISsAT
S543-p	TPVAstHsISsATtP
S545	VAstHsISsATtPDR
S546-p	AstHsISsATtPDRI
T549-p	HsISsATtPDRIRFP
T564	RGTASRSTFHGQPRE
T576-p	PRERRTAtYNGPPAs
Y577	RERRTAtYNGPPAsP
S583-p	tYNGPPAsPSLsHEA
S585	NGPPAsPSLsHEATP
S587-p	PPAsPSLsHEATPLS
T591	PSLsHEATPLSQTRS
S598	TPLSQTRSRGsTNLF
S601-p	SQTRSRGsTNLFSKL
T602	QTRSRGsTNLFSKLT
S606	RGsTNLFSKLTSKLT
S618	KLTRRNMSFRFIKRL
S643	EGSSRNVSSEQKDEN
S657	NREAKPRSLRFTWSM
K681-u	DMMREIRkVLDANNC
Y690	LDANNCDYEQRERFL
K741-u	SGTSIAFkNIASKIA

	rat
T3	_____MSTRTPLPTV
S42	SGARCRNSIASCADE
S45	RCRNSIASCADEQPH
T61	GNYRLLKTIGKGNFA
T90	AIKIIDKTQLNPTSL
T95	DKTQLNPTSLQKLFR
S96	KTQLNPTSLQKLFRE
T211-p	TVGSKLDtFCGSPPY
S215	KLDtFCGSPPYAAPE
K294	FLVLNPVKRGTLEQI
K330	ELDISDQKRIDIMVG
Y340	DIMVGMGYSQEEIQE
S341	IMVGMGYSQEEIQES
S368	YLLLGRKSAELDASD
S374	KSAELDASDSSSSSN
S376	AELDASDSSSSSNLS
S377	ELDASDSSSSSNLSL
S378	LDASDSSSSSNLSLA
S379	DASDSSSSSNLSLAK
S380	ASDSSSSSNLSLAKV
S383	SSSSSNLSLAKVRPS
S391	LAKVRPSSDLSNSTG
S394	VRPSSDLSNSTGQSP
S396	PSSDLSNSTGQSPHH
T397	SSDLSNSTGQSPHHK
S400	LSNSTGQSPHHKGQR
Y418	SSQKQRRYSDHAGPA
S419	SQKQRRYSDHAGPAI
Y432	AIPSVVAYPKRSQTS
T438	AYPKRSQTSTADSDL
S455	DGVPSRKSGSSAVGG
G456	GVPSRKSGSSAVGGK
S469	GKGIAPASPMLGNAS
S476	SPMLGNASNPNKADI
S489	DIPERKKSPAVPSSN
P490	IPERKKSPAVPSSNA
A491	PERKKSPAVPSSNAA
S494	KKSPAVPSSNAASGG
S499	VPSSNAASGGMTRRN
T503	NAASGGMTRRNtYVC
T507-p	GGMTRRNtYVCSERC
Y508	GMTRRNtYVCSERCA
S511	RRNtYVCSERCAADR
S520	RCAADRHSVIQNGKE
T589	ITTPDQRTPVASTHS
S593	DQRTPVASTHSISSA
T594	QRTPVASTHSISSAT
S596	TPVASTHSISSATTP
S598	VASTHSISSATTPDR
S599	ASTHSISSATTPDRI
T602	HSISSATTPDRIRFP
T617	RGTASRSTFHGQPRE
T629	PRERRTATYNGPPAS
Y630	RERRTATYNGPPASP
S636	TYNGPPASPSLSHEA
S638	NGPPASPSLSHEATP
S640	PPASPSLSHEATPLS
T644	PSLSHEATPLSQTRS
S651	TPLSQTRSRGSTNLF
S654	SQTRSRGSTNLFSKL
T655	QTRSRGSTNLFSKLT
S659	RGSTNLFSKLTSKLT
-	gap
S687	EGSSRNVSSEQKDEN
S701	NREAKPRSLRFTWSM
K725	DMMREIRKVLDANTC
Y734-p	LDANTCDyEQRERFL
K785	SGTSIAFKNIASKIA

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