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SLC1A5 (human)

Overview SLC1A5 Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. 1 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB. Protein type: Transporter; Membrane protein, integral Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; melanosome; plasma membrane Molecular Function: neutral amino acid transmembrane transporter activity; receptor activity; sodium:dicarboxylate symporter activity; L-glutamine transmembrane transporter activity Biological Process: neutral amino acid transport; amino acid transport; ion transport; glutamine transport; transmembrane transport Reference #:  Q15758 (UniProtKB) Alt. Names/Synonyms: AAAT; ASCT2; ATB(0); ATBO; Baboon M7 virus receptor; FLJ31068; M7V1; M7VS1; neutral amino acid transporter B; Neutral amino acid transporter B(0); R16; RD114 virus receptor; RD114/simian type D retrovirus receptor; RDR; RDRC; SLC1A5; Sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5 Gene Symbols: SLC1A5 Molecular weight: 56,598 Da Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SLC1A5

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S9-p	VADPPRDskGLAAAE
0	22		K10-u	ADPPRDskGLAAAEP
0	3		S27	NGGLALASIEDQGAA
0	2		G32	LASIEDQGAAAGGyC
0	1		Y38-p	QGAAAGGyCGSRDQV
0	2		K178-u	SAENAPSkEVLDSFL
0	1		S198-p	IFPSNLVsAAFRSYS
0	1		K247-u	VFGVALRkLGPEGEL
0	42		K372-u	EENNGVAkHISRFIL
0	1		E490	QNYVDRTESRstEPE
0	3		S493-p	VDRTESRstEPELIQ
0	5		T494-p	DRTESRstEPELIQV
0	40		K502-u	EPELIQVksELPLDP
0	3		S503-p	PELIQVksELPLDPL
0	8		P506	IQVksELPLDPLPVP
0	28		K522-u	EEGNPLLkHyRGPAG
0	165		Y524-p	GNPLLkHyRGPAGDA
0	1		A531	yRGPAGDAtVAsEkE
0	1		T532-p	RGPAGDAtVAsEkEs
0	4		S535-p	AGDAtVAsEkEsVM_
0	4		K537-a	DAtVAsEkEsVM___
0	69		K537-u	DAtVAsEkEsVM___
0	2		S539-p	tVAsEkEsVM_____

	mouse ► Hide Isoforms
P10	VDPPKADPKGVAVDS
K11	DPPKADPKGVAVDSS
S26	RRCPALGSREDQSAK
S31	LGSREDQSAKAGGCC
C37	QSAKAGGCCGSRDRV
K179	CARSAPTKEALDSFL
S199	IFPSNLVSAAFRSFA
K259	VFGVALRKLGPEGEL
K384-u	EEKNGVAkHISRFIL
K502-u	QSYVDRTkMPSsEPE
S505	VDRTkMPSsEPELIQ
S506-p	DRTkMPSsEPELIQV
K514-u	EPELIQVkNEVsLNP
N515	PELIQVkNEVsLNPL
S518-p	IQVkNEVsLNPLPLA
K534	EEGNPLLKQyQGPTG
Y536-p	GNPLLKQyQGPTGDs
S543-p	yQGPTGDsSATFEKE
S544	QGPTGDsSATFEKES
F547	TGDsSATFEKESVM_
K549	DsSATFEKESVM___
K549	DsSATFEKESVM___
S551	SATFEKESVM_____

	SLC1A5 iso2
P10	VDPPKADPKGVVAVD
K11	DPPKADPKGVVAVDS
S28-p	NGGPALGsREDQsAK
S33-p	LGsREDQsAKAGGCC
C39	QsAKAGGCCGSRDRV
K181-u	CARSAPTkEVLDSFL
S201	IFPSNLVSAAFRSFA
K261	VFGVALRKLGPEGEL
K386	EEKNGVAKHISRFIL
K504	QSYVDRTKMPSSEPE
S507	VDRTKMPSSEPELIQ
S508	DRTKMPSSEPELIQV
K516	EPELIQVKNEVSLNP
N517	PELIQVKNEVSLNPL
S520	IQVKNEVSLNPLPLA
K536	EEGNPLLKQYQGPTG
Y538	GNPLLKQYQGPTGDS
S545	YQGPTGDSSATFEKE
S546	QGPTGDSSATFEKES
F549	TGDSSATFEKESVM_
K551	DSSATFEKESVM___
K551	DSSATFEKESVM___
S553	SATFEKESVM_____

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