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Protein Page:
SLC1A5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC1A5 Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. 1 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; melanosome; plasma membrane
Molecular Function: viral receptor activity; L-serine transmembrane transporter activity; protein binding; neutral amino acid transmembrane transporter activity; receptor activity; sodium:dicarboxylate symporter activity; L-glutamine transmembrane transporter activity
Biological Process: neutral amino acid transport; extracellular amino acid transport; dicarboxylic acid transport; amino acid transport; response to virus; ion transport; glutamine transport; transmembrane transport; L-serine transport
Reference #:  Q15758 (UniProtKB)
Alt. Names/Synonyms: AAAT; ASCT2; ATB(0); ATBO; Baboon M7 virus receptor; FLJ31068; M7V1; M7VS1; neutral amino acid transporter B; Neutral amino acid transporter B(0); R16; RD114 virus receptor; RD114/simian type D retrovirus receptor; RDR; RDRC; SLC1A5; Sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5
Gene Symbols: SLC1A5
Molecular weight: 56,598 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S9-p VADPPRDskGLAAAE
0 22 K10-ub ADPPRDskGLAAAEP
0 5 S27-p NGGLALAsIEDQGAA
0 3 G32 LAsIEDQGAAAGGyC
0 1 Y38-p QGAAAGGyCGSRDQV
0 2 K178-ub SAENAPSkEVLDsFL
0 1 S183-p PSkEVLDsFLDLARN
0 1 S194-p LARNIFPsNLVsAAF
0 1 S198-p IFPsNLVsAAFRSYS
0 1 K247-ub VFGVALRkLGPEGEL
0 42 K372-ub EENNGVAkHISRFIL
0 1 T489 LQNYVDRTESRstEP
0 1 E490 QNYVDRTESRstEPE
0 6 S493-p VDRTESRstEPELIQ
0 7 T494-p DRTESRstEPELIQV
0 40 K502-ub EPELIQVksELPLDP
0 6 S503-p PELIQVksELPLDPL
0 8 P506 IQVksELPLDPLPVP
0 28 K522-ub EEGNPLLkHyRGPAG
0 198 Y524-p GNPLLkHyRGPAGDA
0 1 A531 yRGPAGDAtVAsEkE
0 2 T532-p RGPAGDAtVAsEkEs
0 10 S535-p AGDAtVAsEkEsVM_
0 4 K537-ac DAtVAsEkEsVM___
0 69 K537-ub DAtVAsEkEsVM___
0 5 S539-p tVAsEkEsVM_____
  mouse

► Hide Isoforms
 
P10 VDPPKADPKGVAVDS
K11 DPPKADPKGVAVDSS
S26 RRCPALGSREDQSAK
S31 LGSREDQSAKAGGCC
C37 QSAKAGGCCGSRDRV
K179 CARSAPTKEALDSFL
S184 PTKEALDSFLDLVRN
S195 LVRNIFPSNLVSAAF
S199 IFPSNLVSAAFRSFA
K259 VFGVALRKLGPEGEL
K384-ub EEKNGVAkHISRFIL
T501-p LQSYVDRtkMPssEP
K502-ub QSYVDRtkMPssEPE
S505-p VDRtkMPssEPELIQ
S506-p DRtkMPssEPELIQV
K514-ub EPELIQVkNEVsLNP
N515 PELIQVkNEVsLNPL
S518-p IQVkNEVsLNPLPLA
K534 EEGNPLLKQyQGPTG
Y536-p GNPLLKQyQGPTGDs
S543-p yQGPTGDsSATFEKE
S544 QGPTGDsSATFEKES
F547 TGDsSATFEKESVM_
K549 DsSATFEKESVM___
K549 DsSATFEKESVM___
S551 SATFEKESVM_____
  SLC1A5 iso2  
P10 VDPPKADPKGVVAVD
K11 DPPKADPKGVVAVDS
S28-p NGGPALGsREDQsAK
S33-p LGsREDQsAKAGGCC
C39 QsAKAGGCCGSRDRV
K181-ub CARSAPTkEVLDSFL
S186 PTkEVLDSFLDLVRN
S197 LVRNIFPSNLVSAAF
S201 IFPSNLVSAAFRSFA
K261 VFGVALRKLGPEGEL
K386 EEKNGVAKHISRFIL
T503 LQSYVDRTKMPSSEP
K504 QSYVDRTKMPSSEPE
S507 VDRTKMPSSEPELIQ
S508 DRTKMPSSEPELIQV
K516 EPELIQVKNEVSLNP
N517 PELIQVKNEVSLNPL
S520 IQVKNEVSLNPLPLA
K536 EEGNPLLKQYQGPTG
Y538 GNPLLKQYQGPTGDS
S545 YQGPTGDSSATFEKE
S546 QGPTGDSSATFEKES
F549 TGDSSATFEKESVM_
K551 DSSATFEKESVM___
K551 DSSATFEKESVM___
S553 SATFEKESVM_____
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