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E2A
a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein |
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Cellular Component: transcription factor complex; protein complex; cytoplasm; nucleus
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Molecular Function: protein dimerization activity; protein homodimerization activity; transcription coactivator activity; mitogen-activated protein kinase kinase kinase binding; transcription factor binding; PDZ domain binding; protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity
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Biological Process: response to drug; Peyer's patch development; nervous system development; protein stabilization; transcription, DNA-dependent; immunoglobulin V(D)J recombination; positive regulation of transcription, DNA-dependent; B cell lineage commitment; T cell differentiation in the thymus; positive regulation of cell cycle; response to lipopolysaccharide; regulation of transcription from RNA polymerase II promoter; lymphocyte differentiation; regulation of transcription, DNA-dependent; natural killer cell differentiation; positive regulation of B cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; G1 phase of mitotic cell cycle; cell differentiation; cell development
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Reference #:
NP_001157619 (RefSeq)
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| Alt. Names/Synonyms: A1; AA408400; Alf2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; Immunoglobulin enhancer-binding factor E12/E47; Me2; OTTMUSP00000020636; Pan1; Pan2; TCF-3; Tcf3; Tcfe2a; TFE2; Transcription factor 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; VDIR |
| Gene Symbols: Tcf3 |
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Molecular weight: 67,900 Da
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Basal Isoelectric point: 5.94
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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