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E2A
a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein |
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Cellular Component: nucleoplasm; transcription factor complex; protein complex; cytoplasm; nucleus
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Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; bHLH transcription factor binding; mitogen-activated protein kinase kinase kinase binding; chromatin binding; transcription factor binding; transcription factor activity
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Biological Process: Peyer's patch development; response to drug; transcription, DNA-dependent; protein stabilization; immunoglobulin V(D)J recombination; B cell lineage commitment; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of cell cycle; response to lipopolysaccharide; muscle cell differentiation; regulation of transcription, DNA-dependent; natural killer cell differentiation; B cell differentiation; positive regulation of B cell proliferation; positive regulation of muscle cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; G1 phase of mitotic cell cycle; positive regulation of neuron differentiation; cell development
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Reference #:
P15923 (UniProtKB)
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| Alt. Names/Synonyms: BHLHB21; Class B basic helix-loop-helix protein 21; E2A; E2A immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; ITF1; Kappa-E2-binding factor; MGC129647; MGC129648; TCF-3; TCF3; TFE2; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcription factor E2-alpha; Transcription factor ITF-1; VDIR; VDR interacting repressor |
| Gene Symbols: TCF3 |
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Molecular weight: 67,600 Da
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Basal Isoelectric point: 6
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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