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MEK2 (human)

Overview MEK2 a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB. Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity; STE group; STE7 family Cellular Component: peroxisomal membrane; Golgi apparatus; microtubule; internal side of plasma membrane; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; extracellular region; intercellular junction; cell cortex; cytosol; perinuclear region of cytoplasm; late endosome; nucleus Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activator activity; protein binding; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; protein complex scaffold; ATP binding; PDZ domain binding Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of stress-activated MAPK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway Reference #:  P36507 (UniProtKB) Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP2K2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MP2K2; PRKMK2 Gene Symbols: MAP2K2 Molecular weight: 44,424 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCRs Signaling to MAPK/Erk  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MEK2 1S9I - A/B=55-400 (human) 4H3Q - A=1-360 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1S9I 4H3Q  |  ENZYME  |  Phospho3D  |  DISEASE 115150 601263  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S222‑p, S226‑p enzymatic activity, inhibited: S216‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T13-a	KPVLPALtINPTIAE
0	4		S23-p	PTIAEGPsPTsEGAS
0	1		S26-p	AEGPsPTsEGASEAN
0	1		K40-u	NLVDLQKkLEELELD
0	1		K51-u	LELDEQQkKRLEAFL
0	1		K61-u	LEAFLTQkAkVGELk
0	1		K63-u	AFLTQkAkVGELkDD
0	2		K68-u	kAkVGELkDDDFERI
0	1		S76	DDDFERISELGAGNG
0	1		K88	GNGGVVTKVQHRPsG
0	1		S94-p	TKVQHRPsGLIMARk
0	9		K101-u	sGLIMARkLIHLEIk
0	12		K108-u	kLIHLEIkPAIRNQI
0	27		K196-u	QIMHRDVkPSNILVN
0	12		K209-u	VNSRGEIkLCDFGVs
2	4		S216-p	kLCDFGVsGQLIDsM
41	58		S222-p	VsGQLIDsMANsFVG
6	0		S222-a	VsGQLIDsMANsFVG
42	187		S226-p	LIDsMANsFVGTRSY
2	0		S226-a	LIDsMANsFVGTRSY
0	1		D285-ca	IFGRPVVdGEEGEPH
0	3		S293-p	GEEGEPHsIsPRPRP
0	7		S295-p	EGEPHsIsPRPRPPG
1	1		S306-p	RPPGRPVsGHGMDSR
0	1		K361	PAERADLKMLTNHTF
0	1		S372-p	NHTFIKRsEVEEVDF
0	5		G393	TLRLNQPGtPtRtAV
0	71		T394-p	LRLNQPGtPtRtAV_
1	13		T396-p	LNQPGtPtRtAV___
1	0		T398-p	QPGtPtRtAV_____

	mouse
T13	KPVLPALTINPTIAE
S23	PTIAEGPSPTSEGAS
S26	AEGPSPTSEGASEAN
K40	NLVDLQKKLEELDLD
R51	LDLDEQQRKRLEAFL
K61	LEAFLTQKAKVGELK
K63	AFLTQKAKVGELKDD
K68	KAKVGELKDDDFERI
S76-p	DDDFERIsELGAGNG
K88-u	GNGGVVTkARHRPSG
S94	TkARHRPSGLIMARK
K101	SGLIMARKLIHLEIK
K108	KLIHLEIKPAVRNQI
K196-u	QIMHRDVkPSNILVN
K209	VNSRGEIKLCDFGVs
S216-p	KLCDFGVsGQLIDsM
S222-p	VsGQLIDsMANsFVG
S222-a	VsGQLIDsMANsFVG
S226-p	LIDsMANsFVGTRSY
S226-a	LIDsMANsFVGTRSY
D285	SFGRPVVDGADGEPH
S293-p	GADGEPHsVsPRPRP
S295-p	DGEPHsVsPRPRPPG
S306	RPPGRPISVGHGMDS
K362-u	PAERADLkLLMNHAF
S373	NHAFIKRSEGEEVDF
S394-p	TLRLKQPstPTRTAV
T395-p	LRLKQPstPTRTAV_
T397	LKQPstPTRTAV___
T399	QPstPTRTAV_____

	rat
T13	KPVLPALTINPTIAE
S23	PTIAEGPSPTSEGAS
S26	AEGPSPTSEGASEAH
K40	HLVDLQKKLEELDLD
R51	LDLDEQQRKRLEAFL
K61	LEAFLTQKAKVGELK
K63	AFLTQKAKVGELKDD
K68	KAKVGELKDDDFERI
S76	DDDFERISELGAGNG
K88	GNGGVVTKARHRPSG
S94	TKARHRPSGLIMARK
K101	SGLIMARKLIHLEIK
K108	KLIHLEIKPAVRNQI
K196-u	QIMHRDVkPSNILVN
K209	VNSRGEIKLCDFGVS
S216	KLCDFGVSGQLIDsM
S222-p	VSGQLIDsMANsFVG
S222-a	VSGQLIDsMANsFVG
S226-p	LIDsMANsFVGTRSY
S226	LIDsMANSFVGTRSY
D285	SFGRPVVDGADGEPH
S293	GADGEPHSVsPRPRP
S295-p	DGEPHSVsPRPRPPG
S306	RPPGRPISGHGMDSR
K361	PAERADLKLLTNHAF
S372	NHAFIKRSEGEDVDF
S393-p	TLRLKQPstPTRTAV
T394-p	LRLKQPstPTRTAV_
T396	LKQPstPTRTAV___
T398	QPstPTRTAV_____

	chicken
T13	KPVLPALTITPSPAE
G23	PSPAEGPGPGGSAEA
-	gap
K38	NLVDLQKKLEELELD
K49	LELDEQQKKRLEAFL
K59	LEAFLTQKAKVGELK
K61	AFLTQKAKVGELKDD
K66	KAKVGELKDDDFERI
S74	DDDFERISELGAGNG
K86	GNGGVVTKVQHKPSG
S92	TKVQHKPSGLIMARK
K99	SGLIMARKLIHLEIK
K106	KLIHLEIKPAIRNQI
K194	QIMHRDVKPSNILVN
K207	VNSRGEIKLCDFGVS
S214	KLCDFGVSGQLIDSM
S220	VSGQLIDSMANSFVG
S220	VSGQLIDSMANSFVG
S224	LIDSMANSFVGTRSY
S224	LIDSMANSFVGTRSY
D283	IFGRPVVDGAEGESH
S291	GAEGESHSVSPWARP
S293	EGESHSVSPWARPPG
S304	RPPGRPISGHGMDSR
K359	PAERADLKMLMNHTF
S370	NHTFIKRSEVEEVDF
S391	TLRLNQPSTPTRAAV
T392	LRLNQPSTPTRAAV_
T394	LNQPSTPTRAAV___
A396	QPSTPTRAAV_____

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