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GSTP1 (human)

Overview GSTP1 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family. Note: This description may include information from UniProtKB. Protein type: Other Amino Acids Metabolism - glutathione; EC 2.5.1.18; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase Cellular Component: mitochondrion; cytoplasm; intracellular; nucleus; cytosol Molecular Function: JUN kinase binding; protein binding; glutathione transferase activity; kinase regulator activity Biological Process: negative regulation of JNK activity; negative regulation of MAP kinase activity; central nervous system development; negative regulation of MAPKKK cascade; negative regulation of acute inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of stress-activated MAPK cascade; regulation of stress-activated MAPK cascade; response to reactive oxygen species; negative regulation of biosynthetic process; glutathione metabolic process; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of fibroblast proliferation; xenobiotic metabolic process; positive regulation of superoxide release; negative regulation of protein kinase activity; negative regulation of apoptosis Reference #:  P09211 (UniProtKB) Alt. Names/Synonyms: deafness, X-linked 7; DFN7; FAEES3; fatty acid ethyl ester synthase III; Glutathione S-transferase P; glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; GSTP1; GSTP1-1; PI Gene Symbols: GSTP1 Molecular weight: 23,356 Da Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GSTP1 10GS - A/B=1-210 (human) 11GS - A/B=1-210 (human) 12GS - A/B=1-210 (human) 13GS - A/B=1-210 (human) 14GS - A/B=1-210 (human) 16GS - A/B=1-210 (human) 17GS - A/B=1-210 (human) 18GS - A/B=1-210 (human) 19GS - A/B=1-210 (human) 1AQV - A/B=1-210 (human) 1AQW - A/B/C/D=1-210 (human) 1AQX - A/B/C/D=1-210 (human) 1EOG - A/B=3-210 (human) 1EOH - A/B/C/D/E/F/G/H=1-210 (human) 1GSS - A/B=1-210 (human) 1KBN - A/B=1-210 (human) 1LBK - A/B=2-205 (human) 1MD3 - A/B=1-210 (human) 1MD4 - A/B=1-210 (human) 1PGT - A/B=1-210 (human) 1PX6 - A/B=1-210 (human) 1PX7 - A/B=1-210 (human) 1ZGN - A/B=1-210 (human) 20GS - A/B=1-210 (human) 21GS - A/B=1-210 (human) 22GS - A/B=1-210 (human) 2A2R - A/B=1-210 (human) 2A2S - A/B=1-210 (human) 2GSS - A/B=1-210 (human) 2J9H - A/B=2-210 (human) 2PGT - A/B=1-210 (human) 3CSH - A/B=2-210 (human) 3CSI - A/D/C/B=2-210 (human) 3CSJ - A/B=2-210 (human) 3DD3 - A/B=1-210 (human) 3DGQ - A/B=1-210 (human) 3GSS - A/B=1-210 (human) 3GUS - A/B=2-210 (human) 3HJM - A/D/C/B=2-210 (human) 3HJO - A/B=2-210 (human) 3HKR - A/B=2-210 (human) 3IE3 - A/B=2-210 (human) 3KM6 - A/B=2-210 (human) 3KMN - A/B=2-210 (human) 3KMO - A/B=2-210 (human) 3N9J - A/B=1-210 (human) 3PGT - A/B=1-210 (human) 4GSS - A/B=1-210 (human) 4PGT - A/B=1-210 (human) 5GSS - A/B=1-210 (human) 6GSS - A/B=1-210 (human) 7GSS - A/B=1-210 (human) 8GSS - A/B/C=1-210 (human) 9GSS - A/B=1-210 (human) 1BAY - A/B=1-210 (mouse) 1GLP - A/B=1-210 (mouse) 1GLQ - A/B=1-210 (mouse) 1GSY - A/B=1-210 (mouse) 1GTI - A/B/C/D/E/F=1-210 (mouse) 2GLR - A/B=1-210 (mouse) 2OA7 - A/B=2-210 (mouse) 2OAC - A/B=2-210 (mouse) 2OAD - A/B=2-210 (mouse) 3O76 - A/B=2-210 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 21GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5GSS 6GSS 7GSS 8GSS 9GSS  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: S43‑p, S185‑p enzymatic activity, induced: Y4‑p, Y8‑p, Y199‑p protein conformation: Y4‑p, Y8‑p, Y199‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	5		Y4-p	____MPPyTVVyFPV
1	233		Y8-p	MPPyTVVyFPVRGRC
1	1		S43-p	VETWQEGsLKASCLy
0	13		Y50-p	sLKASCLyGQLPkFQ
0	3		K55-a	CLyGQLPkFQDGDLt
0	3		K55-u	CLyGQLPkFQDGDLt
0	5		T62-p	kFQDGDLtLyQSNTI
1	46		Y64-p	QDGDLtLyQSNTILR
0	1		Y80-p	LGRTLGLyGkDQQEA
0	13		K82-u	RTLGLyGkDQQEAAL
0	3		K103-a	GVEDLRCkYISLIyt
0	5		K103-u	GVEDLRCkYISLIyt
0	57		Y109-p	CkYISLIytNyEAGk
0	4		T110-p	kYISLIytNyEAGkD
0	2		Y112-p	ISLIytNyEAGkDDY
0	2		K116-a	ytNyEAGkDDYVkAL
0	1		K116	ytNyEAGKDDYVkAL
0	2		K121-a	AGkDDYVkALPGQLk
0	2		K121-u	AGkDDYVkALPGQLk
0	5		K128-a	kALPGQLkPFETLLs
0	31		K128-u	kALPGQLkPFETLLs
0	4		S135-p	kPFETLLsQNQGGKT
1	0		S185-p	SAYVGRLsARPKLkA
0	6		K191-a	LsARPKLkAFLASPE
0	10		K191-u	LsARPKLkAFLASPE
1	24		Y199-p	AFLASPEyVNLPING
0	129		K209-a	LPINGNGkQ______
0	2		K209-u	LPINGNGkQ______

	mouse
Y4	____MPPYTIVyFPV
Y8-p	MPPYTIVyFPVRGRC
L43	IDTWMQGLLKPTCLY
Y50	LLKPTCLYGQLPKFE
K55	CLYGQLPKFEDGDLT
K55	CLYGQLPKFEDGDLT
T62	KFEDGDLTLyQSNAI
Y64-p	EDGDLTLyQSNAILR
Y80	LGRSLGLYGkNQREA
K82-u	RSLGLYGkNQREAAQ
K103-a	GVEDLRGkYVTLIyt
K103-u	GVEDLRGkYVTLIyt
Y109-p	GkYVTLIytNYENGk
T110-p	kYVTLIytNYENGkN
Y112	VTLIytNYENGkNDY
K116-a	ytNYENGkNDYVkAL
K116-u	ytNYENGkNDYVkAL
K121-a	NGkNDYVkALPGHLk
K121-u	NGkNDYVkALPGHLk
K128-a	kALPGHLkPFETLLs
K128-u	kALPGHLkPFETLLs
S135-p	kPFETLLsQNQGGKA
S185	SAYVARLSARPKIkA
K191-a	LSARPKIkAFLSSPE
K191-u	LSARPKIkAFLSSPE
H199	AFLSSPEHVNRPING
K209-a	RPINGNGkQ______
K209-u	RPINGNGkQ______

	rat
Y4	____MPPYTIVYFPV
Y8	MPPYTIVYFPVRGRC
S43	IDVWLQGSLKSTCLY
Y50	SLKSTCLYGQLPKFE
K55	CLYGQLPKFEDGDLT
K55	CLYGQLPKFEDGDLT
T62	KFEDGDLTLYQSNAI
Y64	EDGDLTLYQSNAILR
Y80	LGRSLGLYGKDQKEA
K82	RSLGLYGKDQKEAAL
K103	GVEDLRCKYGTLIyT
K103	GVEDLRCKYGTLIyT
Y109-p	CKYGTLIyTNYENGK
T110	KYGTLIyTNYENGKD
Y112	GTLIyTNYENGKDDY
K116	yTNYENGKDDYVKAL
K116	yTNYENGKDDYVKAL
K121	NGKDDYVKALPGHLK
K121	NGKDDYVKALPGHLK
K128	KALPGHLKPFETLLS
K128	KALPGHLKPFETLLS
S135	KPFETLLSQNQGGKA
S185	SAYVARLSARPKIKA
K191	LSARPKIKAFLSSPD
K191	LSARPKIKAFLSSPD
H199	AFLSSPDHLNRPING
K209	RPINGNGKQ______
K209	RPINGNGKQ______

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