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Protein Page:
GSTP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GSTP1 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: extracellular space; mitochondrion; cytoplasm; plasma membrane; intracellular; cytosol; nucleus
Molecular Function: JUN kinase binding; protein binding; glutathione transferase activity; kinase regulator activity
Biological Process: negative regulation of JNK activity; negative regulation of MAP kinase activity; central nervous system development; negative regulation of MAPKKK cascade; negative regulation of acute inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of tumor necrosis factor production; negative regulation of stress-activated MAPK cascade; regulation of stress-activated MAPK cascade; negative regulation of biosynthetic process; response to reactive oxygen species; glutathione metabolic process; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of fibroblast proliferation; positive regulation of superoxide release; xenobiotic metabolic process; negative regulation of protein kinase activity; negative regulation of apoptosis
Reference #:  P09211 (UniProtKB)
Alt. Names/Synonyms: deafness, X-linked 7; DFN7; FAEES3; fatty acid ethyl ester synthase III; Glutathione S-transferase P; glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; GSTP1; GSTP1-1; PI
Gene Symbols: GSTP1
Molecular weight: 23,356 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GSTP1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S43‑p, S185‑p
enzymatic activity, induced: Y4‑p, Y8‑p, Y199‑p
protein conformation: Y4‑p, Y8‑p, Y199‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 5 Y4-p ____MPPyTVVyFPV
1 240 Y8-p MPPyTVVyFPVRGRC
1 1 S43-p VETWQEGsLKAsCLy
0 1 S47-p QEGsLKAsCLyGQLP
0 13 Y50-p sLKAsCLyGQLPkFQ
0 3 K55-ac CLyGQLPkFQDGDLt
0 3 K55-ub CLyGQLPkFQDGDLt
0 8 T62-p kFQDGDLtLyQSNTI
1 48 Y64-p QDGDLtLyQSNTILR
0 1 T76 ILRHLGRTLGLyGkD
0 1 Y80-p LGRTLGLyGkDQQEA
0 1 K82 RTLGLyGKDQQEAAL
0 13 K82-ub RTLGLyGkDQQEAAL
0 4 K103-ac GVEDLRCkYISLIyt
0 5 K103-ub GVEDLRCkYISLIyt
0 1 K103 GVEDLRCKYISLIyt
0 59 Y109-p CkYISLIytNyEAGk
0 4 T110-p kYISLIytNyEAGkD
0 2 Y112-p ISLIytNyEAGkDDY
0 3 K116-ac ytNyEAGkDDYVkAL
0 1 K116 ytNyEAGKDDYVkAL
0 1 K116 ytNyEAGKDDYVkAL
0 3 K121-ac AGkDDYVkALPGQLk
0 2 K121-ub AGkDDYVkALPGQLk
0 6 K128-ac kALPGQLkPFEtLLs
0 31 K128-ub kALPGQLkPFEtLLs
0 1 T132-p GQLkPFEtLLsQNQG
0 9 S135-p kPFEtLLsQNQGGKT
1 0 S185-p SAYVGRLsARPKLkA
0 6 K191-ac LsARPKLkAFLAsPE
0 10 K191-ub LsARPKLkAFLAsPE
0 1 S196-p KLkAFLAsPEyVNLP
1 24 Y199-p AFLAsPEyVNLPING
0 129 K209-ac LPINGNGkQ______
0 1 K209-m3 LPINGNGkQ______
0 2 K209-ub LPINGNGkQ______
  mouse

 
Y4 ____MPPYTIVyFPV
Y8-p MPPYTIVyFPVRGRC
L43 IDTWMQGLLKPTCLY
T47 MQGLLKPTCLYGQLP
Y50 LLKPTCLYGQLPKFE
K55 CLYGQLPKFEDGDLt
K55 CLYGQLPKFEDGDLt
T62-p KFEDGDLtLyQSNAI
Y64-p EDGDLtLyQSNAILR
S76 ILRHLGRSLGLYGkN
Y80 LGRSLGLYGkNQREA
K82-ac RSLGLYGkNQREAAQ
K82-ub RSLGLYGkNQREAAQ
K103-ac GVEDLRGkYVTLIyt
K103-ub GVEDLRGkYVTLIyt
K103-sc GVEDLRGkYVTLIyt
Y109-p GkYVTLIytNYENGk
T110-p kYVTLIytNYENGkN
Y112 VTLIytNYENGkNDY
K116-ac ytNYENGkNDYVkAL
K116-ub ytNYENGkNDYVkAL
K116-sc ytNYENGkNDYVkAL
K121-ac NGkNDYVkALPGHLk
K121-ub NGkNDYVkALPGHLk
K128-ac kALPGHLkPFETLLs
K128-ub kALPGHLkPFETLLs
T132 GHLkPFETLLsQNQG
S135-p kPFETLLsQNQGGKA
S185 SAYVARLSARPKIkA
K191-ac LSARPKIkAFLSSPE
K191-ub LSARPKIkAFLSSPE
S196 KIkAFLSSPEHVNRP
H199 AFLSSPEHVNRPING
K209-ac RPINGNGkQ______
K209 RPINGNGKQ______
K209-ub RPINGNGkQ______
  rat

 
Y4 ____MPPYTIVYFPV
Y8 MPPYTIVYFPVRGRC
S43 IDVWLQGSLKSTCLY
T47 LQGSLKSTCLYGQLP
Y50 SLKSTCLYGQLPKFE
K55 CLYGQLPKFEDGDLT
K55 CLYGQLPKFEDGDLT
T62 KFEDGDLTLYQSNAI
Y64 EDGDLTLYQSNAILR
S76-p ILRHLGRsLGLYGkD
Y80 LGRsLGLYGkDQKEA
K82-ac RsLGLYGkDQKEAAL
K82 RsLGLYGKDQKEAAL
K103 GVEDLRCKYGTLIyT
K103 GVEDLRCKYGTLIyT
K103 GVEDLRCKYGTLIyT
Y109-p CKYGTLIyTNYENGK
T110 KYGTLIyTNYENGKD
Y112 GTLIyTNYENGKDDY
K116 yTNYENGKDDYVKAL
K116 yTNYENGKDDYVKAL
K116 yTNYENGKDDYVKAL
K121 NGKDDYVKALPGHLk
K121 NGKDDYVKALPGHLk
K128-ac KALPGHLkPFETLLS
K128 KALPGHLKPFETLLS
T132 GHLkPFETLLSQNQG
S135 kPFETLLSQNQGGKA
S185 SAYVARLSARPKIkA
K191-ac LSARPKIkAFLSSPD
K191 LSARPKIKAFLSSPD
S196 KIkAFLSSPDHLNRP
H199 AFLSSPDHLNRPING
K209-ac RPINGNGkQ______
K209 RPINGNGKQ______
K209 RPINGNGKQ______
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