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Protein Page:
MAPKAPK3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MAPKAPK3 a member of the MAPKAPK family of protein kinases. Activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.1; CAMK group; MAPKAPK family; MAPKAPK subfamily
Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleus; cytosol
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; response to stress; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q16644 (UniProtKB)
Alt. Names/Synonyms: 3pK; Chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPK3; MAPKAP kinase 3; MAPKAP3; MAPKAPK-3; MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Gene Symbols: MAPKAPK3
Molecular weight: 42,987 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAPKAPK3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T5-p ___MDGEtAEEQGGP
0 12 Y43-p KYAVTDDyQLSKQVL
0 92 Y76-p KCALKLLyDSPKARQ
0 2 K177-a ENLLYTSkEkDAVLK
0 4 K179-a LLYTSkEkDAVLKLT
2 37 T201-p TTQNALQtPCytPyy
0 22 Y204-p NALQtPCytPyyVAP
0 12 T205-p ALQtPCytPyyVAPE
0 10 Y207-p QtPCytPyyVAPEVL
0 6 Y208-p tPCytPyyVAPEVLG
0 1 S244-p CGFPPFYsNtGQAIs
0 1 T246-p FPPFYsNtGQAIsPG
2 1 S251-p sNtGQAIsPGMKRRI
0 1 S307-p NHPWINQsMVVPQtP
2 15 T313-p QsMVVPQtPLHtARV
1 10 T317-p VPQtPLHtARVLQED
0 45 Y346-p LATMRVDyDQVKIKD
  mouse

 
T5 ___MDGETAGEKGSL
Y45-p KYAVTDDyQLSKQVL
Y78-p KCALKLLyDSPKARQ
K179-a ENLLYTSkEKDAVLK
K181 LLYTSkEKDAVLKLT
T203-p TTQNALQtPCYTPYY
Y206 NALQtPCYTPYYVAP
T207 ALQtPCYTPYYVAPE
Y209 QtPCYTPYYVAPEVL
Y210 tPCYTPYYVAPEVLG
S246 CGFPPFYSNTGQAIs
T248 FPPFYSNTGQAIsPG
S253-p SNTGQAIsPGMKRRI
S309 NHPWINQSMVVPQtP
T315-p QSMVVPQtPLYTARV
T319 VPQtPLYTARVLQED
Y348 LATMRVDYDQVKIKD
  rat

 
T5 ___MDGETAGEKGSL
Y45 KYAVTDDYQLSKQVL
Y78 KCALKLLYDSPKARQ
K179 ENLLYTSKEKDAVLK
K181 LLYTSKEKDAVLKLT
T203 TTQNALQTPCYTPYY
Y206 NALQTPCYTPYYVAP
T207 ALQTPCYTPYYVAPE
Y209 QTPCYTPYYVAPEVL
Y210 TPCYTPYYVAPEVLG
S246 CGFPPFYSNTGQAIS
T248 FPPFYSNTGQAISPG
S253 SNTGQAISPGMKRRI
S309 NHPWINQSMEVPQTP
T315 QSMEVPQTPLHTARV
T319 VPQTPLHTARVLEED
Y348 LATMRVDYDQVKIKD
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