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Protein Page:
MAPKAPK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAPKAPK2 a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.1.-; Kinase, protein; EC 2.7.11.1; CAMK group; MAPKAPK family; MAPKAPK subfamily
Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; signal transducer activity; protein binding; ATP binding; protein kinase activity
Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; stress-activated MAPK cascade; leukotriene metabolic process; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; RNA metabolic process; regulation of interleukin-6 production; response to stress; arachidonic acid metabolic process; inflammatory response; inner ear development; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; mRNA metabolic process; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; gene expression; regulation of tumor necrosis factor production; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; G2/M transition DNA damage checkpoint; response to DNA damage stimulus
Reference #:  P49137 (UniProtKB)
Alt. Names/Synonyms: MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPK2; MAPKAP kinase 2; MAPKAPK-2; MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MK2
Gene Symbols: MAPKAPK2
Molecular weight: 45,568 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAPKAPK2

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
activity, induced: T222‑p, S272‑p, T334‑p
enzymatic activity, induced: T334‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3 _____MLSNSQGQsP
0 1 S5 ___MLSNSQGQsPPV
1 0 S9-p LSNSQGQsPPVPFPA
1 0 T25-p APPPQPPtPALPHPP
0 2 Y63-p KNAIIDDyKVtsQVL
0 1 K64 NAIIDDyKVtsQVLG
0 1 T66-p IIDDyKVtsQVLGLG
0 1 S67-p IDDyKVtsQVLGLGI
0 1 T206-p PNAILKLtDFGFAKE
0 1 T214-p DFGFAKEttSHNsLt
0 1 T215-p FGFAKEttSHNsLtt
0 2 S219-p KEttSHNsLttPCyt
0 2 T221-p ttSHNsLttPCytPY
12 43 T222-p tSHNsLttPCytPYY
0 2 Y225-p NsLttPCytPYYVAP
0 4 T226-p sLttPCytPYYVAPE
1 0 S272-p SNHGLAIsPGMKTRI
0 1 T317-p PTQRMTItEFMNHPW
0 5 S328-p NHPWIMQstKVPQtP
0 1 T329-p HPWIMQstKVPQtPL
23 29 T334-p QstKVPQtPLHtsRV
2 17 T338-p VPQtPLHtsRVLKED
0 5 S339-p PQtPLHtsRVLKEDK
0 1 K343 LHtsRVLKEDKERWE
1 0 K353-sm KERWEDVkEEMTSAL
0 27 Y367-p LATMRVDyEQIKIKK
3316 : Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb
3007 : Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb
3041 : Phospho-MAPKAPK-2 (Thr334) Antibody
4320 : Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4338 : Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  mouse

 
S3-p _____MLsGsPGQTP
S5-p ___MLsGsPGQTPPA
T9 LsGsPGQTPPAPFPS
S16 TPPAPFPSPPPPAPA
Y49 KNAITDDYkVTSQVL
K50-ac NAITDDYkVTSQVLG
T52 ITDDYkVTSQVLGLG
S53 TDDYkVTSQVLGLGI
T192 PNAILKLTDFGFAKE
T200 DFGFAKETTSHNsLt
T201 FGFAKETTSHNsLtt
S205-p KETTSHNsLttPCYt
T207-p TTSHNsLttPCYtPY
T208-p TSHNsLttPCYtPYY
Y211 NsLttPCYtPYYVAP
T212-p sLttPCYtPYYVAPE
S258 SNHGLAISPGMKTRI
T303-p PTQRMTItEFMNHPW
S314-p NHPWIMQsTKVPQtP
T315 HPWIMQsTKVPQtPL
T320-p QsTKVPQtPLHtsRV
T324-p VPQtPLHtsRVLkED
S325-p PQtPLHtsRVLkEDK
K329-ac LHtsRVLkEDKERWE
K339 KERWEDVKEEMTSAL
Y353-p LATMRVDyEQIKIKK
3316 : Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb
3007 : Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb
3041 : Phospho-MAPKAPK-2 (Thr334) Antibody
4320 : Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4338 : Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  rat

 
S3 _____MLSGSPGQTP
S5 ___MLSGSPGQTPPA
T9 LSGSPGQTPPAPFPS
S16 TPPAPFPSPPPPAPA
Y49 KNAITDDYKVTSQVL
K50 NAITDDYKVTSQVLG
T52 ITDDYKVTSQVLGLG
S53 TDDYKVTSQVLGLGI
T192 PNAILKLTDFGFAKE
T200 DFGFAKETTSHNSLT
T201 FGFAKETTSHNSLTt
S205 KETTSHNSLTtPCYT
T207 TTSHNSLTtPCYTPY
T208-p TSHNSLTtPCYTPYY
Y211 NSLTtPCYTPYYVAP
T212 SLTtPCYTPYYVAPE
S258 SNHGLAISPGMKTRI
T303 PTQRMTITEFMNHPW
S314 NHPWIMQSTKVPQtP
T315 HPWIMQSTKVPQtPL
T320-p QSTKVPQtPLHTSRV
T324 VPQtPLHTSRVLKED
S325 PQtPLHTSRVLKEDK
K329 LHTSRVLKEDKERWE
K339 KERWEDVKEEMTSAL
Y353 LATMRVDYEQVKIKK
3316 : Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb
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