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MAPKAPK2 (human)

Overview MAPKAPK2 a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.1.-; Protein kinase, CAMK; EC 2.7.11.1; CAMK group; MAPKAPK family; MAPKAPK subfamily Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function: protein serine/threonine kinase activity; signal transducer activity; protein binding; ATP binding; protein kinase activity Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; RNA metabolic process; regulation of interleukin-6 production; response to stress; inflammatory response; inner ear development; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; Toll signaling pathway; mRNA metabolic process; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; gene expression; regulation of tumor necrosis factor production; G2/M transition DNA damage checkpoint; vascular endothelial growth factor receptor signaling pathway; response to DNA damage stimulus Reference #:  P49137 (UniProtKB) Alt. Names/Synonyms: MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPK2; MAPKAP kinase 2; MAPKAPK-2; MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MK2 Gene Symbols: MAPKAPK2 Molecular weight: 45,568 Da Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  Regulation of Microtubule Dynamics  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MAPKAPK2 1KWP - A/B=1-400 (human) 1NXK - A/B/C/D=1-400 (human) 1NY3 - A=1-400 (human) 2JBO - A=41-364 (human) 2JBP - A/B/C/D/E/F/G/H/I/J/K/L=41-364 (human) 2OKR - F=370-393 (human) 2ONL - C/D=1-400 (human) 2OZA - A=47-400 (human) 2P3G - X=45-371 (human) 2PZY - A/B/C/D=41-364 (human) 3A2C - F/A/J/K/E/B/H/C/D/I/G/L=41-364 (human) 3FPM - A=41-364 (human) 3FYJ - X=45-371 (human) 3FYK - X=45-371 (human) 3GOK - F/A/J/K/E/B/H/C/D/I/G/L=41-364 (human) 3KA0 - A=47-366 (human) 3KC3 - F/A/J/K/E/B/H/C/D/I/G/L=41-364 (human) 3KGA - A=47-364 (human) 3M2W - A=47-364 (human) 3M42 - A=47-364 (human) 3R2B - F/A/J/K/E/B/H/C/D/I/G/L=47-364 (human) 3R2Y - A=46-364 (human) 3R30 - A=46-364 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
activation: T222‑p, S272‑p, T334‑p enzymatic activity, induced: T334‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3	_____MLSNSQGQsP
0	1		S5	___MLSNSQGQsPPV
1	0		S9-p	LSNSQGQsPPVPFPA
1	0		T25-p	APPPQPPtPALPHPP
0	2		Y63-p	KNAIIDDyKVtsQVL
0	1		T66-p	IIDDyKVtsQVLGLG
0	1		S67-p	IDDyKVtsQVLGLGI
0	1		T206-p	PNAILKLtDFGFAKE
0	1		T214-p	DFGFAKEttSHNsLt
0	1		T215-p	FGFAKEttSHNsLtt
0	1		S219-p	KEttSHNsLttPCyt
0	1		T221-p	ttSHNsLttPCytPY
11	40		T222-p	tSHNsLttPCytPYY
0	2		Y225-p	NsLttPCytPYYVAP
0	2		T226-p	sLttPCytPYYVAPE
1	0		S272-p	SNHGLAIsPGMKTRI
0	1		T317-p	PTQRMTItEFMNHPW
0	2		S328-p	NHPWIMQstKVPQtP
0	1		T329-p	HPWIMQstKVPQtPL
21	22		T334-p	QstKVPQtPLHtsRV
2	12		T338-p	VPQtPLHtsRVLKED
0	3		S339-p	PQtPLHtsRVLKEDK
0	1		K343	LHtsRVLKEDKERWE
1	0		K353-s	KERWEDVkEEMTSAL
0	27		Y367-p	LATMRVDyEQIKIKK

	mouse
S3-p	_____MLsGsPGQTP
S5-p	___MLsGsPGQTPPA
T9	LsGsPGQTPPAPFPS
P11	GsPGQTPPAPFPSPP
Y49	KNAITDDYKVTSQVL
T52	ITDDYKVTSQVLGLG
S53	TDDYKVTSQVLGLGI
T192	PNAILKLTDFGFAKE
T200	DFGFAKETTSHNSLT
T201	FGFAKETTSHNSLTt
S205	KETTSHNSLTtPCYT
T207	TTSHNSLTtPCYTPY
T208-p	TSHNSLTtPCYTPYY
Y211	NSLTtPCYTPYYVAP
T212	SLTtPCYTPYYVAPE
S258	SNHGLAISPGMKTRI
T303-p	PTQRMTItEFMNHPW
S314-p	NHPWIMQsTKVPQtP
T315	HPWIMQsTKVPQtPL
T320-p	QsTKVPQtPLHtsRV
T324-p	VPQtPLHtsRVLkED
S325-p	PQtPLHtsRVLkEDK
K329-a	LHtsRVLkEDKERWE
K339	KERWEDVKEEMTSAL
Y353-p	LATMRVDyEQIKIKK

	rat
S3	_____MLSGSPGQTP
S5	___MLSGSPGQTPPA
T9	LSGSPGQTPPAPFPS
P11	GSPGQTPPAPFPSPP
Y49	KNAITDDYKVTSQVL
T52	ITDDYKVTSQVLGLG
S53	TDDYKVTSQVLGLGI
T192	PNAILKLTDFGFAKE
T200	DFGFAKETTSHNSLT
T201	FGFAKETTSHNSLTt
S205	KETTSHNSLTtPCYT
T207	TTSHNSLTtPCYTPY
T208-p	TSHNSLTtPCYTPYY
Y211	NSLTtPCYTPYYVAP
T212	SLTtPCYTPYYVAPE
S258	SNHGLAISPGMKTRI
T303	PTQRMTITEFMNHPW
S314	NHPWIMQSTKVPQtP
T315	HPWIMQSTKVPQtPL
T320-p	QSTKVPQtPLHTSRV
T324	VPQtPLHTSRVLKED
S325	PQtPLHTSRVLKEDK
K329	LHTSRVLKEDKERWE
K339	KERWEDVKEEMTSAL
Y353	LATMRVDYEQVKIKK

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