a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 22.214.171.124; Kinase, protein; CAMK group; MAPKAPK family; MAPKAPK subfamily
Molecular Function: calmodulin binding; protein serine/threonine kinase activity; protein binding; signal transducer activity; calcium-dependent protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; mitogen-activated protein kinase binding; ATP binding; protein kinase activity
Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; stress-activated MAPK cascade; leukotriene metabolic process; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of interleukin-6 production; arachidonic acid metabolic process; response to stress; inflammatory response; inner ear development; toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; regulation of tumor necrosis factor production; gene expression; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; G2/M transition DNA damage checkpoint; response to DNA damage stimulus
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.