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Protein Page:
K5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K5 Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: mitochondrion; keratin filament; cytoplasm; plasma membrane; intermediate filament; cytosol; nucleus
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: epidermis development; hemidesmosome assembly
Reference #:  P13647 (UniProtKB)
Alt. Names/Synonyms: 58 kDa cytokeratin; CK-5; CK5; Cytokeratin-5; DDD; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5; K5; keratin 5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin, type II cytoskeletal 5; Keratin-5; KRT5; KRT5A; Type-II keratin Kb5
Gene Symbols: KRT5
Molecular weight: 62,378 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S6-p __MSRQSsVSFRSGG
0 2 S8 MSRQSsVSFRSGGsR
0 1 S14-p VSFRSGGsRsFStAs
0 2 R15 SFRSGGsRsFStAsA
0 4 S16-p FRSGGsRsFStAsAI
0 2 S18 SGGsRsFStAsAItP
0 1 T19-p GGsRsFStAsAItPS
0 7 S21-p sRsFStAsAItPSVS
0 2 T24-p FStAsAItPSVSRTs
0 2 S26 tAsAItPSVSRTsFT
0 1 S28 sAItPSVSRTsFTSV
0 6 S31-p tPSVSRTsFTSVsRs
0 1 T33 SVSRTsFTSVsRsGG
0 1 S34 VSRTsFTSVsRsGGG
0 7 S36-p RTsFTSVsRsGGGGG
0 1 R37 TsFTSVsRsGGGGGG
0 1 S38-p sFTSVsRsGGGGGGG
0 27 S50-p GGGFGRVsLAGACGV
0 322 Y60-p GACGVGGyGsRsLyN
0 22 S62-p CGVGGyGsRsLyNLG
0 4 R63 GVGGyGsRsLyNLGG
0 133 S64-p VGGyGsRsLyNLGGs
0 337 Y66-p GyGsRsLyNLGGskR
0 18 S71-p sLyNLGGskRISIsT
0 2 K72-ac LyNLGGskRISIsTS
0 2 S75 LGGskRISIsTSGGs
0 9 S77-p GskRISIsTSGGsFR
0 1 T78 skRISIsTSGGsFRN
0 8 S82-p SIsTSGGsFRNRFGA
0 3 K173-ub TEEREQIkTLNNkFA
0 30 K178-ac QIkTLNNkFAsFIDk
0 9 K178-ub QIkTLNNkFAsFIDk
0 19 S181-p TLNNkFAsFIDkVRF
0 6 K185-ac kFAsFIDkVRFLEQQ
0 10 K185-ub kFAsFIDkVRFLEQQ
0 1 K194 RFLEQQNKVLDTKWT
0 1 K199 QNKVLDTKWTLLQEQ
0 24 S242-p GERGRLDsELRNMQD
0 4 Y258-p VEDFKNKyEDEINKR
0 9 Y283-p KKDVDAAyMNKVELE
0 1 N332 LSMDNNRNLDLDSII
0 94 Y346-p IAEVKAQyEEIANRS
0 24 Y361-p RTEAESWyQtKyEEL
0 31 T363-p EAESWyQtKyEELQQ
0 42 Y365-p ESWyQtKyEELQQTA
0 1 A398 RMIQRLRAEIDNVKK
0 7 K426-ub QRGELALkDARNKLA
0 11 K472 VEIATYRKLLEGEEC
0 3 - gap
0 1 S574-p SGGGSSSsVKFVSTT
0 1 S587-p TTSSSRKsFKS____
  mouse

 
S6-p __MSRQSsVsFRSGG
S8-p MSRQSsVsFRSGGSR
S14 VsFRSGGSRsFsAAs
R15 sFRSGGSRsFsAAsA
S16-p FRSGGSRsFsAAsAI
S18-p SGGSRsFsAAsAITP
A19 GGSRsFsAAsAITPs
S21-p SRsFsAAsAITPsVs
T24 FsAAsAITPsVsRTs
S26-p AAsAITPsVsRTsFs
S28-p sAITPsVsRTsFssV
S31-p TPsVsRTsFssVsRS
S33-p sVsRTsFssVsRSGG
S34-p VsRTsFssVsRSGGG
S36-p RTsFssVsRSGGGGG
R37 TsFssVsRSGGGGGG
S38 sFssVsRSGGGGGGR
S47-p GGGGGRIsLGGACGA
Y57 GACGAGGYGSRsLYN
S59 CGAGGYGSRsLYNVG
R60 GAGGYGSRsLYNVGG
S61-p AGGYGSRsLYNVGGs
Y63 GYGSRsLYNVGGsKR
S68-p sLYNVGGsKRIsYss
K69 LYNVGGsKRIsYssG
S72-p VGGsKRIsYssGGGs
S74-p GsKRIsYssGGGsFR
S75-p sKRIsYssGGGsFRN
S79-p sYssGGGsFRNQFGA
K167 TEEREQIKTLNNkFA
K172 QIKTLNNKFAsFIDk
K172-ub QIKTLNNkFAsFIDk
S175-p TLNNkFAsFIDkVRF
K179 kFAsFIDKVRFLEQQ
K179-ub kFAsFIDkVRFLEQQ
K188-ub RFLEQQNkVLDTkWA
K193-ub QNkVLDTkWALLQEQ
S236-p GERGRLDsELRNMQD
Y252 VEDYKNKYEDEINKR
Y277 KKDVDAAYMNKVELE
S326-p LSMDNNRsLDLDSII
Y340-p IAEVKAQyEDIANRS
Y355 RTEAESWYQTKYEEL
T357 EAESWYQTKYEELQQ
Y359 ESWYQTKYEELQQTA
S392-p RMIQRLRsEIDNVKK
K420 QRGELALKDARNKLT
K466-ub VEIATYRkLLEGEEC
R526-m1 GLGPRFTrGGGGLGL
S564 SGGGSGSSVKFVSTT
S577 TTSSSRRSFKS____
  rat

 
S6 __MSRQSSVSFRSGG
S8 MSRQSSVSFRSGGSr
S14 VSFRSGGSrSFSAAS
R15-m1 SFRSGGSrSFSAASA
S16 FRSGGSrSFSAASAI
S18 SGGSrSFSAASAITP
A19 GGSrSFSAASAITPS
S21 SrSFSAASAITPSVS
T24 FSAASAITPSVSRTT
S26 AASAITPSVSRTTFS
S28 SAITPSVSRTTFSSV
T31 TPSVSRTTFSSVSrS
S33 SVSRTTFSSVSrSGG
S34 VSRTTFSSVSrSGGG
S36 RTTFSSVSrSGGGGG
R37-m1 TTFSSVSrSGGGGGR
S38 TFSSVSrSGGGGGRV
S46 GGGGGRVSLGGAYGA
Y56 GAYGAGGYGSrSLYN
S58 YGAGGYGSrSLYNVG
R59-m1 GAGGYGSrSLYNVGG
S60 AGGYGSrSLYNVGGS
Y62 GYGSrSLYNVGGSKR
S67 SLYNVGGSKRISFSS
K68 LYNVGGSKRISFSSG
S71 VGGSKRISFSSGGGS
S73 GSKRISFSSGGGSFR
S74 SKRISFSSGGGSFRN
S78 SFSSGGGSFRNQFGA
K169 TEEREQIKTLNNKFA
K174 QIKTLNNKFASFIDK
K174 QIKTLNNKFASFIDK
S177 TLNNKFASFIDKVRF
K181 KFASFIDKVRFLEQQ
K181 KFASFIDKVRFLEQQ
K190 RFLEQQNKVLDTKWT
K195 QNKVLDTKWTLLQEQ
S238 GERGRLDSELRNMQD
Y254 VEDYKNKYEDEINKR
Y279 KKDVDAAYMNKVELE
S328 LSMDNNRSLDLDSII
Y342 IAEVKAQYEDIANRS
Y357 RTEAESWYQTKYEEL
T359 EAESWYQTKYEELQQ
Y361 ESWYQTKYEELQQTA
S394 RMIQRLRSEIDNVKK
K422 QRGELALKDARNKLT
K468 VEIATYRKLLEGEEC
R527 DIGPLLNRRGLGSGL
S560 SGGGSSSSVKFVSTT
S573 TTSSSRRSFKS____
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