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K5 (human)

Overview K5 Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: mitochondrion; cytoplasm; keratin filament; plasma membrane; intermediate filament; cytosol Molecular Function: protein binding; structural constituent of cytoskeleton Biological Process: epidermis development; hemidesmosome assembly Reference #:  P13647 (UniProtKB) Alt. Names/Synonyms: 58 kDa cytokeratin; CK-5; CK5; Cytokeratin-5; DDD; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5; K5; keratin 5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin, type II cytoskeletal 5; Keratin-5; KRT5; KRT5A; Type-II keratin Kb5 Gene Symbols: KRT5 Molecular weight: 62,378 Da Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below K5 3TNU - B=350-477 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE 131760 131800 131900 131960 148040 179850 609352  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S6-p	__MSRQSsVSFRSGG
0	2		S8	MSRQSsVSFRSGGSR
0	2		R15	SFRSGGSRsFStAsA
0	4		S16-p	FRSGGSRsFStAsAI
0	2		S18	SGGSRsFStAsAItP
0	1		T19-p	GGSRsFStAsAItPS
0	7		S21-p	SRsFStAsAItPSVS
0	2		T24-p	FStAsAItPSVSRTs
0	2		S26	tAsAItPSVSRTsFT
0	1		S28	sAItPSVSRTsFTSV
0	6		S31-p	tPSVSRTsFTSVsRs
0	1		T33	SVSRTsFTSVsRsGG
0	1		S34	VSRTsFTSVsRsGGG
0	7		S36-p	RTsFTSVsRsGGGGG
0	1		R37	TsFTSVsRsGGGGGG
0	1		S38-p	sFTSVsRsGGGGGGG
0	26		S50-p	GGGFGRVsLAGACGV
0	323		Y60-p	GACGVGGyGsRsLyN
0	23		S62-p	CGVGGyGsRsLyNLG
0	4		R63	GVGGyGsRsLyNLGG
0	133		S64-p	VGGyGsRsLyNLGGs
0	339		Y66-p	GyGsRsLyNLGGskR
0	18		S71-p	sLyNLGGskRISIsT
0	2		K72-a	LyNLGGskRISIsTS
0	2		S75	LGGskRISIsTSGGs
0	9		S77-p	GskRISIsTSGGsFR
0	1		T78	skRISIsTSGGsFRN
0	8		S82-p	SIsTSGGsFRNRFGA
0	3		K173-u	TEEREQIkTLNNkFA
1	29		K178-a	QIkTLNNkFAsFIDk
0	9		K178-u	QIkTLNNkFAsFIDk
0	15		S181-p	TLNNkFAsFIDkVRF
0	6		K185-a	kFAsFIDkVRFLEQQ
0	10		K185-u	kFAsFIDkVRFLEQQ
0	1		K194	RFLEQQNKVLDTKWT
0	1		K199	QNKVLDTKWTLLQEQ
0	23		S242-p	GERGRLDsELRNMQD
0	4		Y258-p	VEDFKNKyEDEINKR
0	9		Y283-p	KKDVDAAyMNKVELE
0	1		N332	LSMDNNRNLDLDSII
0	94		Y346-p	IAEVKAQyEEIANRS
0	24		Y361-p	RTEAESWyQtKyEEL
0	31		T363-p	EAESWyQtKyEELQQ
0	42		Y365-p	ESWyQtKyEELQQTA
0	1		A398	RMIQRLRAEIDNVKK
0	7		K426-u	QRGELALkDARNKLA
0	1		Y470-p	LDVEIATyRKLLEGE
0	11		K472	VEIATyRKLLEGEEC
0	2		-	gap
0	1		S574-p	SGGGSSSsVKFVSTT
0	1		S587-p	TTSSSRKsFKS____

	mouse
S6-p	__MSRQSsVsFRSGG
S8-p	MSRQSsVsFRSGGSR
R15	sFRSGGSRsFsAAsA
S16-p	FRSGGSRsFsAAsAI
S18-p	SGGSRsFsAAsAITP
A19	GGSRsFsAAsAITPs
S21-p	SRsFsAAsAITPsVs
T24	FsAAsAITPsVsRTs
S26-p	AAsAITPsVsRTsFs
S28-p	sAITPsVsRTsFssV
S31-p	TPsVsRTsFssVsRS
S33-p	sVsRTsFssVsRSGG
S34-p	VsRTsFssVsRSGGG
S36-p	RTsFssVsRSGGGGG
R37	TsFssVsRSGGGGGG
S38	sFssVsRSGGGGGGR
S47-p	GGGGGRIsLGGACGA
Y57	GACGAGGYGSRsLYN
S59	CGAGGYGSRsLYNVG
R60	GAGGYGSRsLYNVGG
S61-p	AGGYGSRsLYNVGGs
Y63	GYGSRsLYNVGGsKR
S68-p	sLYNVGGsKRIsYss
K69	LYNVGGsKRIsYssG
S72-p	VGGsKRIsYssGGGs
S74-p	GsKRIsYssGGGsFR
S75-p	sKRIsYssGGGsFRN
S79-p	sYssGGGsFRNQFGA
K167	TEEREQIKTLNNkFA
K172	QIKTLNNKFAsFIDk
K172-u	QIKTLNNkFAsFIDk
S175-p	TLNNkFAsFIDkVRF
K179	kFAsFIDKVRFLEQQ
K179-u	kFAsFIDkVRFLEQQ
K188-u	RFLEQQNkVLDTkWA
K193-u	QNkVLDTkWALLQEQ
S236-p	GERGRLDsELRNMQD
Y252	VEDYKNKYEDEINKR
Y277	KKDVDAAYMNKVELE
S326-p	LSMDNNRsLDLDSII
Y340-p	IAEVKAQyEDIANRS
Y355	RTEAESWYQTKYEEL
T357	EAESWYQTKYEELQQ
Y359	ESWYQTKYEELQQTA
S392-p	RMIQRLRsEIDNVKK
K420	QRGELALKDARNKLT
Y464	LDVEIATYRkLLEGE
K466-u	VEIATYRkLLEGEEC
R526-m1	GLGPRFTrGGGGLGL
S564	SGGGSGSSVKFVSTT
S577	TTSSSRRSFKS____

	rat
S6	__MSRQSSVSFRSGG
S8	MSRQSSVSFRSGGSr
R15-m1	SFRSGGSrSFSAASA
S16	FRSGGSrSFSAASAI
S18	SGGSrSFSAASAITP
A19	GGSrSFSAASAITPS
S21	SrSFSAASAITPSVS
T24	FSAASAITPSVSRTT
S26	AASAITPSVSRTTFS
S28	SAITPSVSRTTFSSV
T31	TPSVSRTTFSSVSrS
S33	SVSRTTFSSVSrSGG
S34	VSRTTFSSVSrSGGG
S36	RTTFSSVSrSGGGGG
R37-m1	TTFSSVSrSGGGGGR
S38	TFSSVSrSGGGGGRV
S46	GGGGGRVSLGGAYGA
Y56	GAYGAGGYGSrSLYN
S58	YGAGGYGSrSLYNVG
R59-m1	GAGGYGSrSLYNVGG
S60	AGGYGSrSLYNVGGS
Y62	GYGSrSLYNVGGSKR
S67	SLYNVGGSKRISFSS
K68	LYNVGGSKRISFSSG
S71	VGGSKRISFSSGGGS
S73	GSKRISFSSGGGSFR
S74	SKRISFSSGGGSFRN
S78	SFSSGGGSFRNQFGA
K169	TEEREQIKTLNNKFA
K174	QIKTLNNKFASFIDK
K174	QIKTLNNKFASFIDK
S177	TLNNKFASFIDKVRF
K181	KFASFIDKVRFLEQQ
K181	KFASFIDKVRFLEQQ
K190	RFLEQQNKVLDTKWT
K195	QNKVLDTKWTLLQEQ
S238	GERGRLDSELRNMQD
Y254	VEDYKNKYEDEINKR
Y279	KKDVDAAYMNKVELE
S328	LSMDNNRSLDLDSII
Y342	IAEVKAQYEDIANRS
Y357	RTEAESWYQTKYEEL
T359	EAESWYQTKYEELQQ
Y361	ESWYQTKYEELQQTA
S394	RMIQRLRSEIDNVKK
K422	QRGELALKDARNKLT
Y466	LDVEIATYRKLLEGE
K468	VEIATYRKLLEGEEC
R527	DIGPLLNRRGLGSGL
S560	SGGGSSSSVKFVSTT
S573	TTSSSRRSFKS____

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