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Protein Page:
APBA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APBA2 Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: plasma membrane
Molecular Function: protein binding; beta-amyloid binding
Biological Process: nervous system development; synaptic transmission; protein transport; regulation of gene expression; in utero embryonic development; multicellular organism growth; locomotory behavior
Reference #:  Q99767 (UniProtKB)
Alt. Names/Synonyms: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); Amyloid beta A4 precursor protein-binding family A member 2; APBA2; D15S1518E; HsT16821; LIN-10; MGC99508; MGC:14091; Mint-2; MINT2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; X11-like protein; X11L
Gene Symbols: APBA2
Molecular weight: 82,512 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APBA2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S238‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8-p MAHRKLEsVGsGMLD
0 3 S11-p RKLEsVGsGMLDHRV
0 1 Y186-p DQEEDGHyCASKEGy
0 7 Y193-p yCASKEGyQDyyPEE
0 1 Y196-p SKEGyQDyyPEEANG
0 2 Y197-p KEGyQDyyPEEANGN
0 8 S208-p ANGNTGAsPYRLRRG
1 0 S236-p IVAEIKMsLsMTSIT
1 0 S238-p AEIKMsLsMTSITSA
0 1 S244 LsMTSITSASEASPE
0 1 S249 ITSASEASPEHGPEP
0 1 T306-p GFKPKTRtPEERLKW
0 1 K346-ub NNNIPETkKVASFPS
0 1 K439 FISTQRIKVLNADTQ
0 2 S478-p ARRRMPRsAsQDCIE
0 5 S480-p RRMPRsAsQDCIETT
0 1 Y524 GQAFSVAYQEFLRAN
0 1 S609-p NGGPAARsGKLsIGD
0 1 S613-p AARsGKLsIGDQIMS
  mouse

 
S8 MAHRKRQSTASSMLD
S11 RKRQSTASSMLDHRA
Y186 DQEEDGHYCSSKESY
Y193 YCSSKESYQDYYPPE
Y196 SKESYQDYYPPETNG
Y197 KESYQDYYPPETNGN
S209-p NGNTGGAsPYRMRRG
S237-p IVAEIKMsLsMTSIT
S239-p AEIKMsLsMTSITsA
S245-p LsMTSITsASEAsPE
S250-p ITsASEAsPEHMPEL
T307 GLKTKTRTPEERPKW
K347 NNNIPETKKVASFPS
K440-ub FISTQRIkVLNADTQ
S479-p ARRRMPRsASQDCIE
S481 RRMPRsASQDCIETT
Y525-p GQAFSVAyQEFLRAN
S610 NGGPAARSGKLSIGD
S614 AARSGKLSIGDQIMS
  rat

 
S8 MAHRKRQSTASSMLD
S11 RKRQSTASSMLDHRA
Y186 DQEEDGHYCPSKESY
Y193 YCPSKESYQDYYPPE
Y196 SKESYQDYYPPETNG
Y197 KESYQDYYPPETNGN
S209 NGNTGGASPYRMRRG
S237 IVAEIKMSLSMTSIT
S239 AEIKMSLSMTSITSA
S245 LSMTSITSASEASPE
S250 ITSASEASPEHMPEL
T307 GLKTKTRTPEERPKW
K347 NNNIPETKKVASFPS
K440 FISTQRIKVLNADTQ
S479 ARRRMPRSASQDCIE
S481 RRMPRSASQDCIETT
Y525 GQAFSVAYQEFLRAN
S610 NGGPAARSGKLSIGD
S614 AARSGKLSIGDQIMS
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