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Protein Page:
APBA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
APBA2 Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: plasma membrane
Molecular Function: protein binding; beta-amyloid binding
Biological Process: synaptic transmission; nervous system development; protein transport; in utero embryonic development; regulation of gene expression; multicellular organism growth; locomotory behavior
Reference #:  Q99767 (UniProtKB)
Alt. Names/Synonyms: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); Amyloid beta A4 precursor protein-binding family A member 2; APBA2; D15S1518E; HsT16821; LIN-10; MGC99508; MGC:14091; Mint-2; MINT2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; X11-like protein; X11L
Gene Symbols: APBA2
Molecular weight: 82,512 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APBA2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S238‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S11-p RKLESVGsGMLDHRV
0 6 Y193-p YCASKEGyQDYYPEE
0 8 S208-p ANGNTGAsPYRLRRG
1 0 S236-p IVAEIKMsLsMTSIT
1 0 S238-p AEIKMsLsMTSITSA
0 1 S244 LsMTSITSASEASPE
0 1 S249 ITSASEASPEHGPEP
0 1 K439 FISTQRIKVLNADTQ
0 3 S480-p RRMPRSAsQDCIETT
  mouse

 
S11 RKRQSTASSMLDHRA
Y193 YCSSKESYQDYYPPE
S209-p NGNTGGAsPYRMRRG
S237-p IVAEIKMsLsMTSIT
S239-p AEIKMsLsMTSITsA
S245-p LsMTSITsASEAsPE
S250-p ITsASEAsPEHMPEL
K440-u FISTQRIkVLNADTQ
S481 RRMPRSASQDCIETT
  rat

 
S11 RKRQSTASSMLDHRA
Y193 YCPSKESYQDYYPPE
S209 NGNTGGASPYRMRRG
S237 IVAEIKMSLSMTSIT
S239 AEIKMSLSMTSITSA
S245 LSMTSITSASEASPE
S250 ITSASEASPEHMPEL
K440 FISTQRIKVLNADTQ
S481 RRMPRSASQDCIETT
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