Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. Belongs to the kindlin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q22.1
Cellular Component: I band; filamentous actin; extrinsic to internal side of plasma membrane; cell surface; focal adhesion; cytoplasm; nucleolus; stress fiber; cell cortex; nucleus; cytosol
Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding
Alt. Names/Synonyms: DKFZp686G11125; FERM2; Fermitin family homolog 2; fermitin family homolog 2 (Drosophila); FERMT2; FLJ34213; FLJ44462; KIND2; kindlin 2; Kindlin-2; MIG-2; MIG2; mitogen inducible gene 2 protein; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; UNC112; UNC112B
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.