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Protein Page:
P38D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
P38D a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have a few hundred substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of tau and STH. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator Myb in response to stress which leads to rapid Myb degradation via a proteasome-dependent pathway. Phosphorylates and down-regulates PKD1 during regulation of insulin secretion in pancreatic beta cells. Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; Protein kinase, CMGC; EC 2.7.1.37; CMGC group; MAPK family; MAPK/p38 subfamily; p38 subfamily
Cellular Component: cytosol
Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: peptidyl-serine phosphorylation; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; Ras protein signal transduction; MAPKKK cascade; positive regulation of interleukin-6 production; response to stress; response to osmotic stress; cell cycle; positive regulation of inflammatory response
Reference #:  O15264 (UniProtKB)
Alt. Names/Synonyms: MAP kinase 13; MAP kinase p38 delta; MAPK 13; MAPK13; MGC99536; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; MK13; p38delta; PRKM13; SAPK4; Stress-activated protein kinase 4
Gene Symbols: MAPK13
Molecular weight: 42,090 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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P38D

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 23 Y10-p LIRKKGFyKQDVNKT
0 1 S47-p CSAIDKRsGEKVAIK
0 1 Y129 FSEEKIQYLVYQMLK
3 381 T180-p RHADAEMtGyVVtRW
3 980 Y182-p ADAEMtGyVVtRWYR
0 22 T185-p EMtGyVVtRWYRAPE
0 1 K226-ub GKTLFKGkDYLDQLT
0 4 T265-p YIQSLPQtPRKDFTQ
0 1 S350-p YKEIVNFsPIARKDs
0 1 S357-p sPIARKDsRRRsGMK
0 3 S361-p RKDsRRRsGMKL___
  mouse

 
Y10 LTRKRGFYKQDINKT
T47 CSAIDKRTGEKVAIK
Y129-p FSEDKVQyLVYQMLK
T180-p RHTDTEMtGyVVTRW
Y182-p TDTEMtGyVVTRWYR
T185 EMtGyVVTRWYRAPE
K226 GKTLFKGKDYLDQLT
S265-p YIQSLPQsPKKDFTQ
S350 YKEISNFSPIARKDS
S357 SPIARKDSRRRSGMK
S361 RKDSRRRSGMKLQ__
  rat

 
Y10 LIRKRGFYKQDINKT
T47 CSAIDKRTGEKVAIK
Y129 FSEEKVQYLVYQMLK
T180 RHTDAEMTGyVVTRW
Y182-p TDAEMTGyVVTRWYR
T185 EMTGyVVTRWYRAPE
K226 GKTLFKGKDYLDQLT
S265 YIQSLPQSPKKDFTQ
S350 YKEIANFSPIARKDS
S357 SPIARKDSRRRSGMK
S361 RKDSRRRSGMKLQ__
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