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P38D
a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have a few hundred substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of tau and STH. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator Myb in response to stress which leads to rapid Myb degradation via a proteasome-dependent pathway. Phosphorylates and down-regulates PKD1 during regulation of insulin secretion in pancreatic beta cells. Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. This description may include information from UniProtKB.
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| Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24; EC 2.7.1.37; Kinase, protein; Protein kinase, CMGC; CMGC group; MAPK family; p38 subfamily; MAPK/p38 subfamily |
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Cellular Component: cytosol
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Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding
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Biological Process: peptidyl-serine phosphorylation; regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; Ras protein signal transduction; MAPKKK cascade; protein kinase cascade; response to stress; positive regulation of interleukin-6 production; response to osmotic stress; cell cycle; positive regulation of inflammatory response
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Reference #:
O15264 (UniProtKB)
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| Alt. Names/Synonyms: MAP kinase 13; MAP kinase p38 delta; MAPK 13; MAPK13; MGC99536; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; MK13; p38delta; PRKM13; SAPK4; Stress-activated protein kinase 4 |
| Gene Symbols: MAPK13 |
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Molecular weight: 42,090 Da
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Basal Isoelectric point: 8.48
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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B Cell Receptor Signaling
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NF-kB Signaling
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Phospholipase Signaling
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Signaling Pathways Activating p38 MAPK
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-like Receptors Pathway
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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