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JNK3
a protein kinase of the MAPK family that is potently activated by a variety of environmental stress and pro-inflammatory cytokines. Brain-selective JNK isoform. A pro-apoptotic protein and potential tumor suppressor. Phosphorylates a number of transcription factors including c-Jun, ATF2 and ELK1. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity. CDK5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Interacts with HDAC9. Expression lost in brain tumors. May function in neuronal cell death from injury and neurodegeneration, for which inhibitors are being developed. Two alternatively spliced transcript variants have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; EC 2.7.11.24; CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily |
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Cellular Component: nucleoplasm; mitochondrion; plasma membrane; cytosol
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Molecular Function: MAP kinase kinase activity; protein binding; JUN kinase activity; ATP binding
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Biological Process: activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription factor activity; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 4 signaling pathway
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Reference #:
P53779 (UniProtKB)
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| Alt. Names/Synonyms: c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; MGC50974; Mitogen-activated protein kinase 10; MK10; p493F12; p54bSAPK; PRKM10; stress activated protein kinase beta; Stress-activated protein kinase JNK3 |
| Gene Symbols: MAPK10 |
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Molecular weight: 52,585 Da
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Basal Isoelectric point: 6.33
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis
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B Cell Receptor Signaling
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Death Receptor Signaling
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ErbB/HER Signaling
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GPCRs Signaling to MAPK/Erk
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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NF-kB Signaling
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Parkinson's Disease
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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