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Protein Page:
JNK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JNK3 a protein kinase of the MAPK family that is potently activated by a variety of environmental stress and pro-inflammatory cytokines. Brain-selective JNK isoform. A pro-apoptotic protein and potential tumor suppressor. Phosphorylates a number of transcription factors including c-Jun, ATF2 and ELK1. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity. CDK5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Interacts with HDAC9. Expression lost in brain tumors. May function in neuronal cell death from injury and neurodegeneration, for which inhibitors are being developed. Two alternatively spliced transcript variants have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.24; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; MAPK family; JNK subfamily; MAPK/JNK subfamily
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; plasma membrane; cytosol
Molecular Function: MAP kinase kinase activity; protein binding; JUN kinase activity; ATP binding
Biological Process: activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; JUN phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription factor activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  P53779 (UniProtKB)
Alt. Names/Synonyms: c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; MGC50974; Mitogen-activated protein kinase 10; MK10; p493F12; p54bSAPK; PRKM10; stress activated protein kinase beta; Stress-activated protein kinase JNK3
Gene Symbols: MAPK10
Molecular weight: 52,585 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JNK3

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 T131 ISLLNVFTPQKTLEE
0 3 K204-ub VKSDCTLkILDFGLA
0 2 T216-p GLARTAGtsFMMtPy
0 9 S217-p LARTAGtsFMMtPyV
6 403 T221-p AGtsFMMtPyVVtRY
6 1267 Y223-p tsFMMtPyVVtRYYR
0 25 T226-p MMtPyVVtRYYRAPE
0 1 K311 YAGLTFPKLFPDSLF
0 8 K346-ac MLVIDPAkRISVDDA
0 1 K396 EWKELIYKEVMNSEE
0 2 S415 GVVKGQPSPSGAAVN
0 1 S417 VKGQPSPSGAAVNSS
4668 : Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
4668 : Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
  JNK3 iso2  
T131 ISLLNVFTPQKTLEE
K204 VKSDCTLKILDFGLA
T216 GLARTAGTSFMMtPy
S217 LARTAGTSFMMtPyV
T221-p AGTSFMMtPyVVTRY
Y223-p TSFMMtPyVVTRYYR
T226 MMtPyVVTRYYRAPE
K311 YAGLTFPKLFPDSLF
K346-ac MLVIDPAkRISVDDA
K396 EWKELIYKEVMNSEE
S415-p GVVKGQPsPsAQVQQ
S417-p VKGQPsPsAQVQQ__
  mouse

► Hide Isoforms
 
T131 ISLLNVFTPQKTLEE
K204-ub VKSDCTLkILDFGLA
T216 GLARTAGTsFMMtPy
S217-p LARTAGTsFMMtPyV
T221-p AGTsFMMtPyVVtRY
Y223-p TsFMMtPyVVtRYYR
T226-p MMtPyVVtRYYRAPE
K311-ub YAGLTFPkLFPDSLF
K346-ac MLVIDPVkRISVDDA
K396-ub EWKELIYkEVMNSEE
S415 GVVKSQPSPSGAAVN
S417 VKSQPSPSGAAVNSS
4668 : Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
4668 : Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
  JNK3 iso2  
T131 ISLLNVFTPQKTLEE
K204 VKSDCTLKILDFGLA
T216 GLARTAGTSFMMTPY
S217 LARTAGTSFMMTPYV
T221 AGTSFMMTPYVVTRY
Y223 TSFMMTPYVVTRYYR
T226 MMTPYVVTRYYRAPE
K311 YAGLTFPKLFPDSLF
K346 MLVIDPAKRISVDDA
K396 EWKELIYKEVMNSEE
S415-p GVVKGQPsPSAQVQQ
S417 VKGQPsPSAQVQQ__
  JNK3 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
T131-p ISLLNVFtPQKTLEE
K204 VKSDCTLKILDFGLA
T216 GLARTAGTsFMMtPy
S217-p LARTAGTsFMMtPyV
T221-p AGTsFMMtPyVVtRY
Y223-p TsFMMtPyVVtRYYR
T226-p MMtPyVVtRYYRAPE
K311 YAGLTFPKLFPDSLF
K346-ac MLVIDPAkRISVDDA
K396 EWKELIYKEVMNSEE
S415 GVVKGQPSPSGAAVN
S417 VKGQPSPSGAAVNSS
4668 : Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
4668 : Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
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