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Protein Page:
Meis2 (human)

Overview
Meis2 a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Protein type: DNA binding protein
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription cofactor activity; transcription factor binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of myeloid cell differentiation; eye development; response to mechanical stimulus; pancreas development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
Reference #:  O14770 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein Meis2; HsT18361; Meis homeobox 2; Meis homolog 2; Meis1, myeloid ecotropic viral integration site 1 homolog 2; Meis1-related gene 1; Meis1-related protein 1; MEIS2; MGC2820; MRG1; TALE homeobox protein Meis2
Gene Symbols: MEIS2
Molecular weight: 51,790 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Meis2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S198-p ERDGSSKsDHEELSG
0 1 S261 GLDNSVASPGTGDDD
0 1 T264 NSVASPGTGDDDDPD
  mouse

 
S198-p ERDGSSKsDHEELSG
S261-p GLDNSVAsPGtGDDD
T264-p NSVAsPGtGDDDDPD
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