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Protein Page:
BTRC (human)

BTRC a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Cellular Component: SCF ubiquitin ligase complex; cytosol; nucleus
Molecular Function: protein dimerization activity; protein phosphorylated amino acid binding; protein binding; ubiquitin-protein ligase activity; beta-catenin binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; protein polyubiquitination; Wnt receptor signaling pathway; viral reproduction; protein destabilization; positive regulation of proteolysis; regulation of cell cycle; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; mammary gland epithelial cell proliferation; protein ubiquitination; positive regulation of circadian rhythm; protein amino acid dephosphorylation; signal transduction; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of smoothened signaling pathway; mitotic cell cycle; regulation of I-kappaB kinase/NF-kappaB cascade; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent
Reference #:  Q9Y297 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat containing; BETA-TRCP; beta-TrCP1; betaTrCP; BTRC; BTRCP; bTrCP1; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box/WD repeat-containing protein 1A; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643; pIkappaBalpha-E3 receptor subunit
Gene Symbols: BTRC
Molecular weight: 68,867 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  NF-kB Signaling  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 39 Y600-p PRSPSRTyTyISR__
0 34 Y602-p SPSRTyTyISR____

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  BTRC iso2  

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