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Protein Page:
BTRC (human)

Overview
BTRC a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Cellular Component: SCF ubiquitin ligase complex; cytosol; nucleus
Molecular Function: protein dimerization activity; protein phosphorylated amino acid binding; protein binding; ubiquitin-protein ligase activity; beta-catenin binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; viral reproduction; positive regulation of proteolysis; regulation of cell cycle; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; positive regulation of circadian rhythm; protein amino acid dephosphorylation; signal transduction; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of I-kappaB kinase/NF-kappaB cascade; G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein destabilization; negative regulation of transcription factor activity; mammary gland epithelial cell proliferation; regulation of circadian rhythm; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of smoothened signaling pathway; mitotic cell cycle; negative regulation of transcription, DNA-dependent
Reference #:  Q9Y297 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat containing; BETA-TRCP; beta-TrCP1; betaTrCP; BTRC; BTRCP; bTrCP1; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box/WD repeat-containing protein 1A; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643; pIkappaBalpha-E3 receptor subunit
Gene Symbols: BTRC
Molecular weight: 68,867 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  NF-kB Signaling  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BTRC

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S28 RSLWLGCSSLADSMP
0 1 S36 SLADSMPSLRCLYNP
0 1 S127-p VPKQRKLsASYEKEK
0 1 S555-p LRTLVEHsGRVFRLQ
0 42 Y600-p PRSPSRTyTyISR__
0 35 Y602-p SPSRTyTyISR____
  mouse

► Hide Isoforms
 
S28-p RSLWLGCsSLADSMP
S36-p SLADSMPsLRCLYNP
S127 VPKQRKLSASYEKEK
S555 LRTLVEHSGRVFRLQ
Y600-p PRSPSRTyTYISR__
Y602 SPSRTyTYISR____
  BTRC iso2  
- gap
- gap
S91 VPKQRKLSASYEKEK
S519 LRTLVEHSGRVFRLQ
Y564 PRSPSRTYTYISR__
Y566 SPSRTYTYISR____
  rat

 
- gap
- gap
S28 VPKQRKLSASYEKEK
S456 LRTLVEHSGRVFRLQ
Y501-p PRSPSRTyTYISR__
Y503 SPSRTyTYISR____
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