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Protein Page:
JMJD1B (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.11.-; Demethylase
Cellular Component: nucleus
Molecular Function: procollagen-proline dioxygenase activity; 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity; sulfonate dioxygenase activity; dioxygenase activity; metal ion binding; DNA-N1-methyladenine dioxygenase activity; oxidoreductase activity
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification
Reference #:  Q6ZPY7 (UniProtKB)
Alt. Names/Synonyms: 5830462I21Rik; Jhdm2b; JmjC domain-containing histone demethylation protein 2B; Jmjd1b; jumonji domain containing 1B; Jumonji domain-containing protein 1B; Kdm3b; KDM3B lysine (K)-specific demethylase 3B; Kiaa1082; Lysine-specific demethylase 3B; mKIAA1082
Gene Symbols: Kdm3b
Molecular weight: 170,875 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD1B

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 S242 TETGEVKSVDPRLTH
0 1 T248 KSVDPRLTHVMLMDS
0 1 S255 THVMLMDSSTPQSEN
0 3 - gap
0 3 - gap
0 8 - gap
0 3 - gap
0 1 - gap
0 32 - gap
0 2 - gap
0 3 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 1 S281 GVSLSSLSQPLTFGS
0 1 T285 SSLSQPLTFGSGRSQ
0 1 S288 SQPLTFGSGRSQSNG
0 1 S293 FGSGRSQSNGVLATD
0 1 K302 GVLATDNKPLGFSFS
0 1 S347-p YLSRVSEsVADDsss
0 2 S352-p SEsVADDsssRDsFT
0 3 S353-p EsVADDsssRDsFTQ
0 8 S354-p sVADDsssRDsFTQs
0 12 S357-p DDsssRDsFTQsLES
0 3 S361-p sRDsFTQsLESLTSG
0 1 S374 SGLCKGRSVLGADTQ
0 1 T380 RSVLGADTQPGPKAG
0 1 S389 PGPKAGSSVDRKVPA
0 17 T403 AESMPTLTPAFPRSL
0 1 S409 LTPAFPRSLLNTRTP
0 16 T415 RSLLNTRTPENHENL
0 1 S448 FVEKVEHSPFSSFVS
0 1 T497-gl KKPLFITtDSSKLVs
0 2 S504-p tDSSKLVsGVLGSAL
0 1 S509 LVsGVLGSALSTGsP
0 1 S512 GVLGSALSTGsPsLS
0 1 S515-p GSALSTGsPsLSAVG
0 1 S517-p ALSTGsPsLSAVGNG
0 3 S526-p SAVGNGRssSPtNsL
0 1 S527-p AVGNGRssSPtNsLt
0 5 T530-p NGRssSPtNsLtQPI
0 1 N531 GRssSPtNsLtQPIE
0 2 S532-p RssSPtNsLtQPIEM
0 3 T534-p sSPtNsLtQPIEMPt
0 3 T541-p tQPIEMPtLsSsPtE
0 1 S543-p PIEMPtLsSsPtEER
0 6 S545-p EMPtLsSsPtEERPt
0 1 T547-p PtLsSsPtEERPtVG
0 3 T552-p sPtEERPtVGPGQQD
0 2 S567 NPLLKTFSTVFGRHS
0 44 S574 STVFGRHSGSFLSAP
0 13 S579 RHSGSFLSAPAEFAQ
0 37 A580 HSGSFLSAPAEFAQE
0 6 A585 LSAPAEFAQENKAPF
0 9 S599-p FEAVKRFsLDERSLA
0 1 T972 GGGAAAVTNPEPDQV
0 1 N973 GGAAAVTNPEPDQVP
0 1 K994 GRSEEPLKAEGSASN
0 1 A995 RSEEPLKAEGSASNS
0 1 G997 EEPLKAEGSASNSNS
0 1 S998 EPLKAEGSASNSNSE
0 1 S1000 LKAEGSASNSNSELK
0 1 S1004 GSASNSNSELKAIRP
0 1 S1046 KDAGSLRSVLNKESH
0 2 K1050 SLRSVLNKESHsPFG
0 2 S1052 RSVLNKESHsPFGLD
0 20 S1054-p VLNKESHsPFGLDSF
0 3 S1060 HsPFGLDSFNSTAKV
0 1 S1063 FGLDSFNSTAKVsPL
0 1 T1064 GLDSFNSTAKVsPLt
0 1 K1066 DSFNSTAKVsPLtPk
0 6 S1068-p FNSTAKVsPLtPkLF
0 6 T1071-p TAKVsPLtPkLFNSL
0 3 K1073-ub KVsPLtPkLFNSLLL
0 1 S1077 LtPkLFNSLLLGPTA
0 2 K1088-ub GPTASNSkTEGSSLR
0 1 T1089 PTASNSkTEGSSLRD
0 4 S1100 SLRDLLHSGPGKLPQ
0 2 K1104 LLHSGPGKLPQTPLD
0 27 T1108 GPGKLPQTPLDTGIP
0 2 T1112 LPQTPLDTGIPFPPV
0 2 K1128 SSSSAVAKSKASLPD
0 1 K1130 SSAVAKSKASLPDFL
0 1 S1132 AVAKSKASLPDFLDH
0 1 K1148 IASVVENKKTSDPSK
0 1 K1317 LPLPEYTKRDGRLNL
0 1 K1401 GDADEVTKQRIHDGK
0 1 K1553 KDAVGTLKAHESKLA
  JMJD1B iso3  
S242-p TETGEVKsVDPRLtH
T248-p KsVDPRLtHVMLMDs
S255-p tHVMLMDsSTPQSEG
T264-p TPQSEGGtIKAVKSS
S279-p KGKKKREsIEGRDGR
S290-p RDGRRRKsASDSGCD
S292 GRRRKsASDSGCDPA
T300 DSGCDPATKKLKGDR
K301 SGCDPATKKLKGDRG
S312 GDRGEVDSNGSDGGE
S315 GEVDSNGSDGGEASR
S321 GSDGGEASRGPWKGG
R356 PQINRNIRFATYTKE
T359 NRNIRFATYTKENGR
K362 IRFATYTKENGRTLV
T379 DEPVGGDTPVPFTPY
T384 GDTPVPFTPYASATG
S438 TPTTVRISDtGLASG
T440-p TTVRISDtGLASGTG
S481 GVSLSSLSQPLTFGS
T485 SSLSQPLTFGSGRSQ
S488 SQPLTFGSGRSQSNG
S493 FGSGRSQSNGVLATD
K502 GVLATDNKPLGFSFS
S547 YLSRVSESVADDSSS
S552 SESVADDSSSRDSFT
S553 ESVADDSSSRDSFTQ
S554 SVADDSSSRDSFTQS
S557 DDSSSRDSFTQSLES
S561 SRDSFTQSLESLTSG
S574 SGLCKGRSVLGADTQ
T580 RSVLGADTQPGPKAG
S589 PGPKAGSSVDRKVPA
T603 AESMPTLTPAFPRSL
S609 LTPAFPRSLLNTRTP
T615 RSLLNTRTPENHENL
S648 FVEKVEHSPFSSFVS
T697 KKPLFITTDSSKLVS
S704 TDSSKLVSGVLGSAL
S709 LVSGVLGSALSTGSP
S712 GVLGSALSTGSPSLS
S715 GSALSTGSPSLSAVG
S717 ALSTGSPSLSAVGNG
S726 SAVGNGRSSSPTNSL
S727 AVGNGRSSSPTNSLT
T730 NGRSSSPTNSLTQPI
N731 GRSSSPTNSLTQPIE
S732 RSSSPTNSLTQPIEM
T734 SSPTNSLTQPIEMPT
T741 TQPIEMPTLSSSPTE
S743 PIEMPTLSSSPTEER
S745 EMPTLSSSPTEERPT
T747 PTLSSSPTEERPTVG
T752 SPTEERPTVGPGQQD
S767 NPLLKTFSTVFGRHS
S774 STVFGRHSGSFLSAP
S779 RHSGSFLSAPAEFAQ
A780 HSGSFLSAPAEFAQE
A785 LSAPAEFAQENKAPF
S799 FEAVKRFSLDERSLA
T1172 GGGAAAVTNPEPDQV
N1173 GGAAAVTNPEPDQVP
K1194 GRSEEPLKAEGSASN
A1195 RSEEPLKAEGSASNS
G1197 EEPLKAEGSASNSNS
S1198 EPLKAEGSASNSNSE
S1200 LKAEGSASNSNSELK
S1204 GSASNSNSELKAIRP
S1246 KDAGSLRSVLNKESH
K1250 SLRSVLNKESHSPFG
S1252 RSVLNKESHSPFGLD
S1254 VLNKESHSPFGLDSF
S1260 HSPFGLDSFNSTAKV
S1263 FGLDSFNSTAKVSPL
T1264 GLDSFNSTAKVSPLT
K1266 DSFNSTAKVSPLTPK
S1268 FNSTAKVSPLTPKLF
T1271 TAKVSPLTPKLFNSL
K1273 KVSPLTPKLFNSLLL
S1277 LTPKLFNSLLLGPTA
K1288 GPTASNSKTEGSSLR
T1289 PTASNSKTEGSSLRD
S1300 SLRDLLHSGPGKLPQ
K1304 LLHSGPGKLPQTPLD
T1308 GPGKLPQTPLDTGIP
T1312 LPQTPLDTGIPFPPV
K1328 SSSSAVAKSKASLPD
K1330 SSAVAKSKASLPDFL
S1332 AVAKSKASLPDFLDH
K1348 IASVVENKKTSDPSK
K1517 LPLPEYTKRDGRLNL
K1601 GDADEVTKQRIHDGK
K1753 KDAVGTLKAHESKLA
  human

 
S241 TESGEIKSVDPRLIH
I247 KSVDPRLIHVMLMDN
N254 IHVMLMDNSAPQSEG
T263-p APQSEGGtLKAVKSS
S278-p KGKKKREsIEGKDGR
S289-p KDGRRRKsAsDSGCD
S291-p GRRRKsAsDSGCDPA
S299-p DSGCDPAskKLKGDR
K300-ac SGCDPAskKLKGDRG
S311-p GDRGEVDsNGsDGGE
S314-p GEVDsNGsDGGEAsR
S320-p GsDGGEAsRGPWKGG
R355-m1 PQINRNIrFAtYTkE
T358-p NRNIrFAtYTkENGR
K361-ac IrFAtYTkENGRTLV
T378-p DEPVGGDtPASFtPY
T383-p GDtPASFtPYSTATG
S437-p TPNTVRIsDtGLAAG
T439-p NTVRIsDtGLAAGTV
S480-p GAPLPSSsQPLtFGs
T484-p PSSsQPLtFGsGRSQ
S487-p sQPLtFGsGRSQsNG
S492-p FGsGRSQsNGVLATE
K501-ac GVLATENkPLGFSFG
S546 YFTTVSESLADDsss
S551-p SESLADDsssRDsFK
S552-p ESLADDsssRDsFKQ
S553-p SLADDsssRDsFKQs
S556-p DDsssRDsFKQsLES
S560-p sRDsFKQsLESLSSG
S573-p SGLCKGRsVLGTDtK
T579-p RsVLGTDtKPGSKAG
S588-p PGSKAGSsVDRKVPA
T602-p AESMPTLtPAFPRsL
S608-p LtPAFPRsLLNARtP
T614-p RsLLNARtPENHENL
S647-p FVEKVEHsPFSSFAS
T696 KKPLFITTDSSKLVs
S703-p TDSSKLVsGVLGsAL
S708-p LVsGVLGsALtSGGP
T711-p GVLGsALtSGGPSLS
G714 GsALtSGGPSLSAMG
S716 ALtSGGPSLSAMGNG
S725-p SAMGNGRssSPtssL
S726-p AMGNGRssSPtssLt
T729-p NGRssSPtssLtQPI
S730-p GRssSPtssLtQPIE
S731-p RssSPtssLtQPIEM
T733-p sSPtssLtQPIEMPt
T740-p tQPIEMPtLSSsPtE
S742 PIEMPtLSSsPtEER
S744-p EMPtLSSsPtEERPT
T746-p PtLSSsPtEERPTVG
T751 sPtEERPTVGPGQQD
S766-p NPLLKTFsNVFGRHs
S773-p sNVFGRHsGGFLssP
S778-p RHsGGFLssPADFsQ
S779-p HsGGFLssPADFsQE
S784-p LssPADFsQENKAPF
S798-p FEAVKRFsLDERSLA
T1171-p GGGPAPVttPEPDHV
T1172-p GGPAPVttPEPDHVP
K1193-ub IRSEEPLktDssAsN
T1194-p RSEEPLktDssAsNS
S1196-p EEPLktDssAsNSNs
S1197-p EPLktDssAsNSNsE
S1199-p LktDssAsNSNsELK
S1203-p ssAsNSNsELKAIRP
S1245-p KEAGSLRsVLNkEsH
K1249-ub SLRsVLNkEsHsPFG
S1251-p RsVLNkEsHsPFGLD
S1253-p VLNkEsHsPFGLDsF
S1259-p HsPFGLDsFNstAkV
S1262-p FGLDsFNstAkVsPL
T1263-p GLDsFNstAkVsPLt
K1265-ub DsFNstAkVsPLtPk
S1267-p FNstAkVsPLtPkLF
T1270-p tAkVsPLtPkLFNsL
K1272-ub kVsPLtPkLFNsLLL
S1276-p LtPkLFNsLLLGPTA
K1287-ub GPTASNNktEGSSLR
T1288-p PTASNNktEGSSLRD
S1299-p SLRDLLHsGPGkLPQ
K1303-ub LLHsGPGkLPQtPLD
T1307-p GPGkLPQtPLDtGIP
T1311-p LPQtPLDtGIPFPPV
K1327-ub STSSAGVkSkAsLPN
K1329-ub SSAGVkSkAsLPNFL
S1331-p AGVkSkAsLPNFLDH
K1347-ub IASVVENkKTSDASK
K1516-ub LPLPEYTkRDGRLNL
K1600-ub GDADEVTkQRIHDGK
K1752-m2 KDAVGTLkAHESKLA
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