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JMJD1B (mouse)

Overview JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase; EC 1.14.11.-; Demethylase Cellular Component: nucleus Reference #:  NP_001074725 (RefSeq) Alt. Names/Synonyms: 5830462I21Rik; Jhdm2b; JmjC domain-containing histone demethylation protein 2B; Jmjd1b; jumonji domain containing 1B; Jumonji domain-containing protein 1B; Kdm3b; KDM3B lysine (K)-specific demethylase 3B; Kiaa1082; Lysine-specific demethylase 3B; mKIAA1082 Gene Symbols: Kdm3b Molecular weight: 191,460 Da Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JMJD1B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	2		T264	TPQSEGGTIKAVKSS
0	1		S279-p	KGKKKREsIEGRDGR
0	7		S290-p	RDGRRRKsASDSGCD
0	2		S292	GRRRKsASDSGCDPA
0	1		T300	DSGCDPATKKLKGDR
0	32		K301	SGCDPATKKLKGDRG
0	1		S312	GDRGEVDSNGSDGGE
0	1		S315	GEVDSNGSDGGEASR
0	2		T359	NRNIRFATYTKENGR
0	1		K362	IRFATYTKENGRTLV
0	1		T379	DEPVGGDTPVPFTPY
0	1		T384	GDTPVPFTPYASATG
0	1		S438	TPTTVRISDTGLASG
0	1		T440	TTVRISDTGLASGTG
0	1		S481	GVSLSSLSQPLTFGS
0	1		S547-p	YLSRVSEsVADDsss
0	2		S552-p	SEsVADDsssRDsFT
0	3		S553-p	EsVADDsssRDsFTQ
0	8		S554-p	sVADDsssRDsFTQs
0	12		S557-p	DDsssRDsFTQsLES
0	2		S561-p	sRDsFTQsLESLTSG
0	1		S574	SGLCKGRSVLGADTQ
0	1		T580	RSVLGADTQPGPKAG
0	1		S589	PGPKAGSSVDRKVPA
0	17		T603	AESMPTLTPAFPRSL
0	1		S609	LTPAFPRSLLNTRTP
0	15		T615	RSLLNTRTPENHENL
0	1		T697-g	KKPLFITtDSSKLVS
0	1		S704	tDSSKLVSGVLGSAL
0	1		S709	LVSGVLGSALSTGSP
0	1		S712	GVLGSALSTGSPSLS
0	1		S726-p	SAVGNGRssSPtNsL
0	1		S727-p	AVGNGRssSPtNsLt
0	4		T730-p	NGRssSPtNsLtQPI
0	1		N731	GRssSPtNsLtQPIE
0	2		S732-p	RssSPtNsLtQPIEM
0	3		T734-p	sSPtNsLtQPIEMPT
0	2		T741	tQPIEMPTLsSsPtE
0	1		S743-p	PIEMPTLsSsPtEER
0	4		S745-p	EMPTLsSsPtEERPt
0	1		T747-p	PTLsSsPtEERPtVG
0	1		T752-p	sPtEERPtVGPGQQD
0	1		S767	NPLLKTFSTVFGRHS
0	41		S774	STVFGRHSGSFLSAP
0	12		S779	RHSGSFLSAPAEFAQ
0	34		A780	HSGSFLSAPAEFAQE
0	5		A785	LSAPAEFAQENKAPF
0	5		S799-p	FEAVKRFsLDERSLA
0	1		K1194	GRSEEPLKAEGSASN
0	1		A1195	RSEEPLKAEGSASNS
0	1		G1197	EEPLKAEGSASNSNS
0	1		S1198	EPLKAEGSASNSNSE
0	1		S1200	LKAEGSASNSNSELK
0	2		K1250	SLRSVLNKESHsPFG
0	1		S1252	RSVLNKESHsPFGLD
0	18		S1254-p	VLNKESHsPFGLDSF
0	1		S1260	HsPFGLDSFNSTAKV
0	1		K1266	DSFNSTAKVsPLtPk
0	4		S1268-p	FNSTAKVsPLtPkLF
0	5		T1271-p	TAKVsPLtPkLFNSL
0	3		K1273-u	KVsPLtPkLFNSLLL
0	1		S1277	LtPkLFNSLLLGPTA
0	2		K1288-u	GPTASNSkTEGSSLR
0	4		S1300	SLRDLLHSGPGKLPQ
0	2		K1304	LLHSGPGKLPQTPLD
0	27		T1308	GPGKLPQTPLDTGIP
0	2		T1312	LPQTPLDTGIPFPPV
0	2		K1328	SSSSAVAKSKASLPD
0	1		K1330	SSAVAKSKASLPDFL
0	1		S1332	AVAKSKASLPDFLDH
0	1		K1348	IASVVENKKTSDPSK
0	1		K1517	LPLPEYTKRDGRLNL
0	1		K1601	GDADEVTKQRIHDGK
0	1		K1753	KDAVGTLKAHESKLA

	human
T263-p	APQSEGGtLKAVKSS
S278-p	KGKKKREsIEGKDGR
S289-p	KDGRRRKsAsDSGCD
S291-p	GRRRKsAsDSGCDPA
S299-p	DSGCDPAskKLKGDR
K300-a	SGCDPAskKLKGDRG
S311-p	GDRGEVDsNGsDGGE
S314-p	GEVDsNGsDGGEASR
T358-p	NRNIRFAtYTkENGR
K361-a	IRFAtYTkENGRTLV
T378-p	DEPVGGDtPASFtPY
T383-p	GDtPASFtPYSTATG
S437-p	TPNTVRIsDtGLAAG
T439-p	NTVRIsDtGLAAGTV
S480-p	GAPLPSSsQPLTFGS
S546	YFTTVSESLADDsss
S551-p	SESLADDsssRDsFK
S552-p	ESLADDsssRDsFKQ
S553-p	SLADDsssRDsFKQs
S556-p	DDsssRDsFKQsLES
S560-p	sRDsFKQsLESLSSG
S573-p	SGLCKGRsVLGTDtK
T579-p	RsVLGTDtKPGSKAG
S588-p	PGSKAGSsVDRKVPA
T602-p	AESMPTLtPAFPRsL
S608-p	LtPAFPRsLLNARtP
T614-p	RsLLNARtPENHENL
T696	KKPLFITTDSSKLVs
S703-p	TDSSKLVsGVLGsAL
S708-p	LVsGVLGsALtSGGP
T711-p	GVLGsALtSGGPSLS
S725	SAMGNGRSsSPtssL
S726-p	AMGNGRSsSPtssLt
T729-p	NGRSsSPtssLtQPI
S730-p	GRSsSPtssLtQPIE
S731-p	RSsSPtssLtQPIEM
T733-p	sSPtssLtQPIEMPt
T740-p	tQPIEMPtLSSsPTE
S742	PIEMPtLSSsPTEER
S744-p	EMPtLSSsPTEERPT
T746	PtLSSsPTEERPTVG
T751	sPTEERPTVGPGQQD
S766-p	NPLLKTFsNVFGRHs
S773-p	sNVFGRHsGGFLssP
S778-p	RHsGGFLssPADFsQ
S779-p	HsGGFLssPADFsQE
S784-p	LssPADFsQENKAPF
S798-p	FEAVKRFsLDERSLA
K1193-u	IRSEEPLktDssAsN
T1194-p	RSEEPLktDssAsNS
S1196-p	EEPLktDssAsNSNS
S1197-p	EPLktDssAsNSNSE
S1199-p	LktDssAsNSNSELK
K1249-u	SLRSVLNkEsHsPFG
S1251-p	RSVLNkEsHsPFGLD
S1253-p	VLNkEsHsPFGLDsF
S1259-p	HsPFGLDsFNSTAkV
K1265-u	DsFNSTAkVsPLtPk
S1267-p	FNSTAkVsPLtPkLF
T1270-p	TAkVsPLtPkLFNsL
K1272-u	kVsPLtPkLFNsLLL
S1276-p	LtPkLFNsLLLGPTA
K1287-u	GPTASNNkTEGSSLR
S1299-p	SLRDLLHsGPGkLPQ
K1303-u	LLHsGPGkLPQtPLD
T1307-p	GPGkLPQtPLDtGIP
T1311-p	LPQtPLDtGIPFPPV
K1327-u	STSSAGVkSkAsLPN
K1329-u	SSAGVkSkAsLPNFL
S1331-p	AGVkSkAsLPNFLDH
K1347-u	IASVVENkKTSDASK
K1516-u	LPLPEYTkRDGRLNL
K1600-u	GDADEVTkQRIHDGK
K1752-m2	KDAVGTLkAHESKLA

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