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Protein Page:
JMJD1B (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase
Cellular Component: nucleus
Molecular Function: molecular_function; dioxygenase activity; metal ion binding; oxidoreductase activity
Biological Process: biological_process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
Reference #:  B9EKS2 (UniProtKB)
Alt. Names/Synonyms: 5830462I21Rik; Jhdm2b; JmjC domain-containing histone demethylation protein 2B; Jmjd1b; jumonji domain containing 1B; Jumonji domain-containing protein 1B; Kdm3b; KDM3B lysine (K)-specific demethylase 3B; Kiaa1082; Lysine-specific demethylase 3B; mKIAA1082
Gene Symbols: Kdm3b
Molecular weight: 191,460 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S242-p TETGEVKsVDPRLtH
0 1 T248-p KsVDPRLtHVMLMDs
0 1 S255-p tHVMLMDsSTPQSEG
0 3 T264-p TPQSEGGtIKAVKSS
0 3 S279-p KGKKKREsIEGRDGR
0 8 S290-p RDGRRRKsASDSGCD
0 2 S292 GRRRKsASDSGCDPA
0 32 K301 SGCDPATKKLKGDRG
0 1 S312 GDRGEVDSNGSDGGE
0 2 S315 GEVDSNGSDGGEASR
0 1 R356 PQINRNIRFATYTKE
0 2 T359 NRNIRFATYTKENGR
0 1 K362 IRFATYTKENGRTLV
0 1 S493 FGSGRSQSNGVLATD
0 1 S547-p YLSRVSEsVADDsss
0 2 S552-p SEsVADDsssRDsFT
0 3 S553-p EsVADDsssRDsFTQ
0 8 S554-p sVADDsssRDsFTQs
0 12 S557-p DDsssRDsFTQsLES
0 3 S561-p sRDsFTQsLESLTSG
0 1 S574 SGLCKGRSVLGADTQ
0 17 T603 AESMPTLTPAFPRSL
0 1 S609 LTPAFPRSLLNTRTP
0 16 T615 RSLLNTRTPENHENL
0 1 T697-gl KKPLFITtDSSKLVS
0 3 S726-p SAVGNGRssSPtNsL
0 1 S727-p AVGNGRssSPtNsLt
0 4 T730-p NGRssSPtNsLtQPI
0 1 N731 GRssSPtNsLtQPIE
0 2 S732-p RssSPtNsLtQPIEM
0 3 T734-p sSPtNsLtQPIEMPt
0 3 T741-p tQPIEMPtLsSsPtE
0 1 S743-p PIEMPtLsSsPtEER
0 5 S745-p EMPtLsSsPtEERPt
0 1 T747-p PtLsSsPtEERPtVG
0 2 T752-p sPtEERPtVGPGQQD
0 2 S767 NPLLKTFSTVFGRHS
0 43 S774 STVFGRHSGSFLSAP
0 13 S779 RHSGSFLSAPAEFAQ
0 36 A780 HSGSFLSAPAEFAQE
0 5 A785 LSAPAEFAQENKAPF
0 8 S799-p FEAVKRFsLDERSLA
0 1 K1194 GRSEEPLKAEGSASN
0 2 K1250 SLRSVLNKESHsPFG
0 1 S1252 RSVLNKESHsPFGLD
0 20 S1254-p VLNKESHsPFGLDSF
0 2 S1260 HsPFGLDSFNSTAKV
0 5 S1268-p FNSTAKVsPLtPkLF
0 5 T1271-p TAKVsPLtPkLFNSL
0 3 K1273-u KVsPLtPkLFNSLLL
0 2 K1288-u GPTASNSkTEGSSLR
0 4 S1300 SLRDLLHSGPGKLPQ
0 2 K1304 LLHSGPGKLPQTPLD
0 27 T1308 GPGKLPQTPLDTGIP
0 2 T1312 LPQTPLDTGIPFPPV
0 2 K1328 SSSSAVAKSKASLPD
0 1 K1517 LPLPEYTKRDGRLNL
0 1 K1601 GDADEVTKQRIHDGK
  human

 
S241 TESGEIKSVDPRLIH
I247 KSVDPRLIHVMLMDN
N254 IHVMLMDNSAPQSEG
T263-p APQSEGGtLKAVKSS
S278-p KGKKKREsIEGKDGR
S289-p KDGRRRKsAsDSGCD
S291-p GRRRKsAsDSGCDPA
K300-a SGCDPASkKLKGDRG
S311-p GDRGEVDsNGsDGGE
S314-p GEVDsNGsDGGEASR
R355-m1 PQINRNIrFAtYTkE
T358-p NRNIrFAtYTkENGR
K361-a IrFAtYTkENGRTLV
S492-p FGSGRSQsNGVLATE
S546 YFTTVSESLADDsss
S551-p SESLADDsssRDsFK
S552-p ESLADDsssRDsFKQ
S553-p SLADDsssRDsFKQs
S556-p DDsssRDsFKQsLES
S560-p sRDsFKQsLESLSSG
S573-p SGLCKGRsVLGTDTK
T602-p AESMPTLtPAFPRsL
S608-p LtPAFPRsLLNARtP
T614-p RsLLNARtPENHENL
T696 KKPLFITTDSSKLVS
S725-p SAMGNGRssSPtssL
S726-p AMGNGRssSPtssLt
T729-p NGRssSPtssLtQPI
S730-p GRssSPtssLtQPIE
S731-p RssSPtssLtQPIEM
T733-p sSPtssLtQPIEMPt
T740-p tQPIEMPtLSSsPTE
S742 PIEMPtLSSsPTEER
S744-p EMPtLSSsPTEERPT
T746 PtLSSsPTEERPTVG
T751 sPTEERPTVGPGQQD
S766-p NPLLKTFsNVFGRHs
S773-p sNVFGRHsGGFLssP
S778-p RHsGGFLssPADFsQ
S779-p HsGGFLssPADFsQE
S784-p LssPADFsQENKAPF
S798-p FEAVKRFsLDERSLA
K1193-u IRSEEPLkTDSSASN
K1249-u SLRSVLNkEsHsPFG
S1251-p RSVLNkEsHsPFGLD
S1253-p VLNkEsHsPFGLDsF
S1259-p HsPFGLDsFNSTAKV
S1267-p FNSTAKVsPLtPkLF
T1270-p TAKVsPLtPkLFNSL
K1272-u KVsPLtPkLFNSLLL
K1287-u GPTASNNkTEGSSLR
S1299-p SLRDLLHsGPGkLPQ
K1303-u LLHsGPGkLPQtPLD
T1307-p GPGkLPQtPLDtGIP
T1311-p LPQtPLDtGIPFPPV
K1327-u STSSAGVkSKASLPN
K1516-u LPLPEYTkRDGRLNL
K1600-u GDADEVTkQRIHDGK
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