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IkB-epsilon (mouse)

Overview IkB-epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein; DNA binding protein Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm Biological Process: negative regulation of transcription, DNA-dependent; D-serine transport Reference #:  O54910 (UniProtKB) Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; Ikbe; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; Nfkbie; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon Gene Symbols: Nfkbie Molecular weight: 39,200 Da Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling

Select Structure to View Below IkB-epsilon

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	Sites Implicated In
protein degradation: S18‑p, S22‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		-	gap
0	1		S14	GPDEADDSQCDsGIE
0	217		C16	DEADDSQCDsGIEsL
1	4		S18-p	ADDSQCDsGIEsLRS
2	1		S22-p	QCDsGIEsLRSLRSL
0	1		S25	sGIEsLRSLRSLPEP
0	1		K180	VVRALVLKGASRILQ

	human ► Hide Isoforms
S54-p	RVRRPCWsGGAGRGG
S153-p	GPDEAEEsQyDsGIE
Y155-p	DEAEEsQyDsGIEsL
S157-p	AEEsQyDsGIEsLRs
S161-p	QyDsGIEsLRsLRSL
S164-p	sGIEsLRsLRSLPES
K316-u	AVRALVLkGASRALQ

	IkB-epsilon iso3
-	gap
S76	GPDEAEESQyDSGIE
Y78-p	DEAEESQyDSGIESL
S80	AEESQyDSGIESLRS
S84	QyDSGIESLRSLRSL
S87	SGIESLRSLRSLPES
K239	AVRALVLKGASRALQ

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