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Protein Page:
AKAP1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Mitochondrial; Adaptor/scaffold
Cellular Component: postsynaptic membrane; mitochondrial outer membrane; mitochondrial crista; membrane; mitochondrion; endoplasmic reticulum; mitochondrial matrix; mitochondrial inner membrane; integral to membrane; lipid particle; neuromuscular junction
Molecular Function: protein domain specific binding; protein binding; RNA binding; microtubule binding; beta-tubulin binding; protein complex scaffold; protein phosphatase binding; protein kinase binding; protein phosphatase 2B binding
Biological Process: negative regulation of protein amino acid dephosphorylation; negative regulation of NFAT protein import into nucleus
Reference #:  O08715 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; Akap; Akap1; AKAP121; AKAP84; C76494; C81186; D-AKAP-1; DAKAP1; Dual specificity A-kinase-anchoring protein 1; OTTMUSP00000001248; OTTMUSP00000001249; PRKA1; Protein kinase A-anchoring protein 1; S-AKAP; S-AKAP84; Spermatid A-kinase anchor protein
Gene Symbols: Akap1
Molecular weight: 92,195 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AKAP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 48 S55-p AIKDRRLsEEACPGV
0 3 S64-p EACPGVLsVAPTVTQ
0 11 V65 ACPGVLsVAPTVTQP
0 2 T68 GVLsVAPTVTQPPGR
0 38 S101-p TRQVRRRsEssGNLP
0 45 S103-p QVRRRsEssGNLPsV
0 10 S104-p VRRRsEssGNLPsVA
0 2 S109-p EssGNLPsVADTRsQ
0 4 S115-p PsVADTRsQPGPCRD
0 1 I124 PGPCRDEIAKVELSL
0 1 K135-ub ELSLMGDkAKSIPLG
0 1 L146 IPLGCPLLPKDAsFP
1 5 - gap
0 1 S151-p PLLPKDAsFPYEAVE
0 2 - gap
1 2 - gap
0 1 - gap
0 5 S164 VERCKQESALGKTPG
0 8 S315 QAAFQLISQVILEAT
0 8 L319 QLISQVILEATEEFR
0 7 T322 SQVILEATEEFRATT
0 2 T328 ATEEFRATTVGKtVA
0 1 T333-p RATTVGKtVAQVHPT
0 2 S378-p TRTGATAsPSAEALP
0 3 - gap
0 2 S395-p TYVSCLSsPLSGPTK
0 1 S398 SCLSsPLSGPTKDQK
0 6 - gap
0 1 T401 SsPLSGPTKDQKPKN
0 27 T487-p SSGDKAMtPPLPVST
0 1 T519-p EDGWTMDtEADHsGG
0 1 S524-p MDtEADHsGGsDGNs
0 2 S527-p EADHsGGsDGNsMDS
0 2 S531-p sGGsDGNsMDSVDSC
0 1 S534 sDGNsMDSVDSCCGL
0 1 S537 NsMDSVDSCCGLTKP
0 1 C539 MDSVDSCCGLTKPDS
0 1 T542 VDSCCGLTKPDSPQS
0 5 S546 CGLTKPDSPQSVQAG
0 1 S554 PQSVQAGSNPKKVDL
0 2 K588-ub GRYVSFLkQTSGAKI
0 1 K627-ub KALNLIGkKFKELNL
0 1 K754 YVDYGGYKRVKVDVL
0 4 Y854 AQWVDSYYASL____
0 3 S856 WVDSYYASL______
  human

► Hide Isoforms
 
V60 AIKEPLPVEDVCPKV
S69-p DVCPKVVstPPsVTE
T70-p VCPKVVstPPsVTEP
S73-p KVVstPPsVTEPPEK
S105-p THPPCRRsEssGILP
S107-p PPCRRsEssGILPNT
S108-p PCRRsEssGILPNTT
N113 EssGILPNTTDMRLR
L119 PNTTDMRLRPGTRRD
S128-p PGTRRDDsTKLELAL
E139 ELALTGGEAKSIPLE
S150-p IPLECPLssPKGVLF
S151-p PLECPLssPKGVLFs
- gap
S158-p sPKGVLFssKsAEVC
S159-p PKGVLFssKsAEVCK
S161-p GVLFssKsAEVCKQD
S169-p AEVCKQDsPFSRVPR
S353-p RAAFQIIsQVIsEAt
S357-p QIIsQVIsEAtEQVL
T360-p sQVIsEAtEQVLAtT
T366-p AtEQVLAtTVGKVAG
V371 LAtTVGKVAGRVCQA
- gap
S429-p PGLPAEGsPPPKTYV
S441 TYVSCLKSLLssPtK
S444-p SCLKSLLssPtKDSK
S445-p CLKSLLssPtKDSKP
T447-p KSLLssPtKDSKPNI
T533-p SPRDKAItPPLPEST
A565 EDGWTMDAEADHSGG
S570 MDAEADHSGGsDRNs
S573-p EADHSGGsDRNsMDs
S577-p SGGsDRNsMDsVDsC
S580-p sDRNsMDsVDsCCsL
S583-p NsMDsVDsCCsLKKt
S586-p DsVDsCCsLKKtEsF
T590-p sCCsLKKtEsFQNAQ
S592-p CsLKKtEsFQNAQAG
S600-p FQNAQAGsNPKKVDL
K634-ub GRYVSFLkQTSGAKI
K673 KALNLIGKKFKELNL
K800-ub YVDYGGYkRVKVDVL
Y900-p AQWVDSYyTsL____
S902-p WVDSYyTsL______
  AKAP1 iso3  
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  rat

 
T55 AIEDRLPTEEACPGV
S64 EACPGVLSVTPSVTQ
V65 ACPGVLSVTPSVTQP
S68 GVLSVTPSVTQPPGK
S101-p TRQVRRRsEssGNLP
S103-p QVRRRsEssGNLPSI
S104-p VRRRsEssGNLPSIV
S109 EssGNLPSIVDTRLQ
L115 PSIVDTRLQAGQCSD
N124 AGQCSDENSKVVLSL
E135 VLSLMGDEAKSIPLG
F146 IPLGRPLFPKDLSFP
- gap
S151 PLFPKDLSFPYEAVE
- gap
- gap
- gap
S164 VEGCKQESALGRTPG
S312 QTAFQIISQVILEAT
L316 QIISQVILEATEEIR
T319 SQVILEATEEIRATT
T325 ATEEIRATTVGKTVA
T330 RATTVGKTVAQVHPT
S375-p TRTGATAsPSAGAPP
- gap
S392 TYVSCLSSPLSGPTK
S395 SCLSSPLSGPTKDQK
- gap
T398 SSPLSGPTKDQKPKN
T484 SSGDKAVTPPLPDST
T516 EDGWTMDTEADHSGG
S521 MDTEADHSGGSDGNS
S524 EADHSGGSDGNSMDS
S528 SGGSDGNSMDSVDSC
S531 SDGNSMDSVDSCCGL
S534 NSMDSVDSCCGLTKP
C536 MDSVDSCCGLTKPDS
T539 VDSCCGLTKPDSPQT
S543 CGLTKPDSPQTVQAG
S551 PQTVQAGSNPKKVDL
K585 GRYVSFLKQTSGAKI
K624 KALNLIGKKFKELNL
K751 YVDYGGYKRVKVDVL
Y851 AQWVDSCYASL____
S853 WVDSCYASL______
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