an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Nuclear receptor co-regulator; AGC group; NDR family
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding
Biological Process: keratinocyte differentiation; mitosis; hormone-mediated signaling; cell division; protein kinase cascade; negative regulation of cyclin-dependent protein kinase activity; regulation of organ growth; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.