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Protein Page:
LATS2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LATS2 an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Kinase, protein; Nuclear receptor co-regulator; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family
Cellular Component: spindle pole; microtubule organizing center; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding
Biological Process: keratinocyte differentiation; mitosis; hormone-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; regulation of organ growth; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle
Reference #:  Q9NRM7 (UniProtKB)
Alt. Names/Synonyms: FLJ13161; Kinase phosphorylated during mitosis protein; KPM; Large tumor suppressor homolog 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS2; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Warts-like kinase
Gene Symbols: LATS2
Molecular weight: 120,136 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LATS2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S408‑p
cell cycle regulation: S408‑p
intracellular localization: S83‑p, S380‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5-p ___MRPKtFPAttys
0 1 T9-p RPKtFPAttysGNSR
0 1 T10-p PKtFPAttysGNSRQ
0 1 Y11-p KtFPAttysGNSRQR
0 1 S12-p tFPAttysGNSRQRL
0 1 K27 QEIREGLKQPSKSSV
0 1 K31 EGLKQPSKSSVQGLP
0 1 K50 SDTSLDAKVLGSkDA
0 1 K55-ac DAKVLGSkDATRQQQ
0 2 Y82-p KALREIRysLLPFAN
4 0 S83-p ALREIRysLLPFANE
0 1 Y135-p SIEAALEyISKMGYL
0 1 K154 EQIVRVIKQTSPGKG
0 1 K160 IKQTSPGKGLMPTPV
2 5 S172-p TPVTRRPsFEGTGDS
0 1 T279-p SPSFQSKtPPETGGy
0 35 Y286-p tPPETGGyAsLPTKG
0 1 S288-p PETGGyAsLPTKGQG
2 13 S380-p ATLARRDsLQKPGLE
1 1 S408-p PVPSRTNsFNSHQPR
1 0 S446-p HILHPVKsVRVLRPE
0 2 S528-p HLLLRSKsEQyDLDs
0 1 Y531-p LRSKsEQyDLDsLCA
0 1 S535-p sEQyDLDsLCAGMEQ
0 1 S543-p LCAGMEQsLRAGPNE
0 1 K565-ac RKSAKGDkGGKDkkQ
0 1 K570-ac GDkGGKDkkQIQTsP
0 1 K571-ac DkGGKDkkQIQTsPV
0 1 S576-p DkkQIQTsPVPVRKN
0 1 T690-p CLACKVDtHALYAMK
1 0 S835-p GSHVRQDsMEPSDLW
1 9 S872-p HQRCLAHsLVGTPNY
0 1 A975 KAHPFFSAIDFSSDI
0 1 T1024-p GSTKAWDtLTsPNNK
0 1 S1027-p KAWDtLTsPNNKHPE
1 0 T1041-p EHAFYEFtFRRFFDD
0 1 Y1051-p RFFDDNGyPFRCPKP
  mouse

 
T5 ___MRPKTFPATTYS
T9 RPKTFPATTYSGNSR
T10 PKTFPATTYSGNSRQ
Y11 KTFPATTYSGNSRQR
S12 TFPATTYSGNSRQRL
K27-ub QEIREGLkQPSkAST
K31-ub EGLkQPSkASTQGLL
K50-ub SDTSLDAkVLGSKDA
K55 DAkVLGSKDASRQQQ
Y81 KALREIRYSLLPFAN
S82 ALREIRYSLLPFANE
Y134 SIEAALEYISKMGYL
K153-ac EQIVRVIkQTSPGkG
K159-ac IkQTSPGkGLAPTPV
S171-p TPVTRRPsFEGTGEA
T267 SSSFQNKTPPDAYSS
Y272 NKTPPDAYSSMAKAQ
S273 KTPPDAYSSMAKAQG
S362-p APLARRDsLQKQGLE
S386 AGPSRTNSFNNPQPE
S416 HILHPVKSVRVLRPE
S485 HLLLPSKSEQYSVDL
Y488 LPSKSEQYSVDLDSL
S494 QYSVDLDSLCTSVQQ
S502 LCTSVQQSLRGGTEQ
K523 HKGAKGDKAGRDKKQ
K528 GDKAGRDKKQIQTSP
K529 DKAGRDKKQIQTSPV
S534 DKKQIQTSPVPVRKN
T648 CLACKLDTHALYAMK
S793 GNHMRQDSMEPGDLW
S830-p HQRCLAHsLVGTPNY
T933-p KAHPFFNtIDFSRDI
T982 ESAKAWDTLASPSSK
S985 KAWDTLASPSSKHPE
T999 EHAFYEFTFRRFFDD
Y1009 RFFDDNGYPFRCPKP
  rat

 
T5 ___MRPKTFPATTYS
T9 RPKTFPATTYSGNSR
T10 PKTFPATTYSGNSRQ
Y11 KTFPATTYSGNSRQR
S12 TFPATTYSGNSRQRL
K27 QEIREGLKQPAKSST
K31 EGLKQPAKSSTQGLL
K51 DTSSLDAKVLGNKDA
K56 DAKVLGNKDASRQQQ
Y82 KALREIRYSLLPFAN
S83 ALREIRYSLLPFANE
Y135 SIEAALEYISKMGYL
K154 EQIVRVIKQTSPGKG
K160 IKQTSPGKGLVPTAV
S172-p TAVTRRPsFEGTGEA
T266 SPSFQSKTPPDTYSS
Y271 SKTPPDTYSSLAKAQ
S272 KTPPDTYSSLAKAQG
S361 APLARRDSLQKQSLE
S385 AGPSRTNSFSSPQPE
S415 HILHPVKSVRVLRPE
S485 HLLLPSKSEQYSAGL
Y488 LPSKSEQYSAGLDRL
R494 QYSAGLDRLCTGVEQ
S502 LCTGVEQSLRGGTEQ
K523 HKGAKGDKAGRDKKQ
K528 GDKAGRDKKQIQTSP
K529 DKAGRDKKQIQTSPV
S534 DKKQIQTSPVPVRKN
T648 CLACKVDTHALYAMK
S793 GNHIRQDSMEPGDLW
S830 HQRCLAHSLVGTPNY
T933 KAHPFFSTIDFSRDI
T982 ESAKAWDTLASPNSK
S985 KAWDTLASPNSKHPE
T999 EHAFYEFTFRRFFDD
Y1009 RFFDDNGYPFRCPKP
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