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TAP2
a 'transporter associated with antigen processing' (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Transports peptides across the endoplasmic reticulum membrane for assembly of major histocompatibility complex class I molecules. Two subunits, TAP1 and TAP2, are required for peptide transport. ATP hydrolysis is important for transport activity. Nascent MHC class I molecules associate with TAP via tapasin. Note: This description may include information from UniProtKB.
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| Protein type: Transporter; Membrane protein, integral |
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Cellular Component: endoplasmic reticulum membrane; TAP complex; endoplasmic reticulum; mitochondrial inner membrane; plasma membrane; integral to membrane; integral to endoplasmic reticulum membrane; nucleus
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Molecular Function: tapasin binding; protein binding; peptide transporter activity; TAP1 binding; peptide antigen binding; MHC class I protein binding; transporter activity; TAP2 binding; peptide antigen-transporting ATPase activity; oligopeptide-transporting ATPase activity; ATP binding
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Biological Process: peptide transport; intracellular transport of viral proteins in host cell; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; cytosol to ER transport; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; peptide antigen transport; transmembrane transport; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
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Reference #:
NP_000535 (RefSeq)
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| Alt. Names/Synonyms: ABC transporter, MHC 2; ABC-transporter; ABC18; ABCB3; antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; D6S217E; peptide supply factor 2; peptide transporter involved in antigen processing 2; peptide transporter PSF2; peptide transporter TAP2; PSF-2; PSF2; really interesting new gene 11 protein; RING11; TAP2; transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| Gene Symbols: TAP2 |
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Molecular weight: 77,695 Da
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Basal Isoelectric point: 7.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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