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Protein Page:
TAP2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TAP2 a 'transporter associated with antigen processing' (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Transports peptides across the endoplasmic reticulum membrane for assembly of major histocompatibility complex class I molecules. Two subunits, TAP1 and TAP2, are required for peptide transport. ATP hydrolysis is important for transport activity. Nascent MHC class I molecules associate with TAP via tapasin. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter
Cellular Component: endoplasmic reticulum membrane; TAP complex; mitochondrial inner membrane; integral to membrane; plasma membrane; integral to endoplasmic reticulum membrane
Molecular Function: tapasin binding; protein binding; peptide transporter activity; peptide antigen binding; TAP1 binding; MHC class I protein binding; transporter activity; TAP2 binding; peptide antigen-transporting ATPase activity; oligopeptide-transporting ATPase activity; ATP binding
Biological Process: peptide transport; intracellular transport of viral proteins in host cell; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; cytosol to ER transport; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; peptide antigen transport; transmembrane transport; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Reference #:  Q03519 (UniProtKB)
Alt. Names/Synonyms: ABC transporter, MHC 2; ABC-transporter; ABC18; ABCB3; antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; D6S217E; peptide supply factor 2; peptide transporter involved in antigen processing 2; peptide transporter PSF2; peptide transporter TAP2; PSF-2; PSF2; really interesting new gene 11 protein; RING11; TAP2; transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Symbols: TAP2
Molecular weight: 75,664 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 K54-u GGLWGLLkLRGLLGF
0 2 K135-u EQDQVNNkVLMWRLL
0 62 K245-u LGFFQETkTGELNSR
0 16 K356-u EHEVCRYkEALEQCR
0 1 Q450 VFSYMDRQPNLPSPG
0 2 Y597-p QEMEHGIyTDVGEkG
0 1 K603-u IyTDVGEkGSQLAAG
0 5 K612-u SQLAAGQkQRLAIAR
0 3 K679-u ILVLQEGkLQKLAQL
0 1 K682 LQEGkLQKLAQL___
0 158 - gap
  TAP2 iso3  
K55 GGLWGLLKLRGLLGF
K136 EQDQVNNKVLMWRLL
K246 LGFFQETKTGELNSR
K357 EHEVCRYKEALEQCR
Q451 VFSYMDRQPNLPSPG
Y598 QEMEHGIYTDVGEKG
K604 IYTDVGEKGSQLAAG
K613 SQLAAGQKQRLAIAR
K680 ILVLQEGKLQkLAQL
K683-u LQEGKLQkLAQLQEG
Y694-p LQEGQDLySRLVQQR
  mouse

 
K54 GVLWGLLKVGELLGL
R134 KEPGQENRTLMKRLL
K244-u LGFFQETkTGELNSR
K355-u EQEVSHYkEALERCR
K449-u VFSYLDRkPNLPQPG
N596 GEMTNGINTEIGEKG
K602 INTEIGEKGGQLAVG
K611 GQLAVGQKQRLAIAR
R678 VLVLKQGRLVEHDQL
E681 LKQGRLVEHDQLRDG
Y692 LRDGQDVYAHLVQQR
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