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HIPK2
homeodomain interacting protein kinase 2 is a CMGC kinase of the DYRK family. Interacts with TRADD. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB. Highly expressed in neuronal tissues, heart and kidney. Weakly expressed ubiquitously. Possible tumor suppressor. Activates p53 in response to UV light, causing growth arrest and apoptosis. Required for cisplatin-induced apoptosis. Downregulated in breast and thyroid carcinomas. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, CMGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; DYRK family; HIPK subfamily |
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Cellular Component: nuclear body; centrosome; PML body; nuclear membrane; cytoplasm; nucleus
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Molecular Function: protein serine/threonine kinase activity; protein binding; virion binding; SMAD binding; transcription corepressor activity; ATP binding; protein kinase activity
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Biological Process: voluntary musculoskeletal movement; positive regulation of protein binding; regulation of cell cycle; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; PML body organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; adult walking behavior; negative regulation of BMP signaling pathway; anterior/posterior pattern formation; neuron differentiation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; erythrocyte differentiation; negative regulation of neuron apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; positive regulation of DNA binding; smoothened signaling pathway; peptidyl-threonine phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of angiogenesis; peptidyl-serine phosphorylation; eye development; embryonic retina morphogenesis in camera-type eye; virus-host interaction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; embryonic camera-type eye morphogenesis
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Reference #:
Q9H2X6 (UniProtKB)
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| Alt. Names/Synonyms: DKFZp686K02111; FLJ23711; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; Homeodomain-interacting protein kinase 2; PRO0593 |
| Gene Symbols: HIPK2 |
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Molecular weight: 130,966 Da
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Basal Isoelectric point: 8.69
Predict pI for various phosphorylation states
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CST Pathways:
Cell Cycle: G2/M DNA Damage Checkpoint
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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