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Protein Page:
ACTG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ACTG1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: filamentous actin; extracellular space; cytoskeleton; myofibril; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; ATP binding
Biological Process: axon guidance; retinal homeostasis; intercellular junction assembly and maintenance; innate immune response; sarcomere organization; cell motility
Reference #:  P63261 (UniProtKB)
Alt. Names/Synonyms: ACTB; ACTG; ACTG1; Actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed; actin, gamma 1; cytoskeletal gamma-actin; DFNA20; DFNA26; Gamma-actin
Gene Symbols: ACTG1
Molecular weight: 41,793 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACTG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S14 ALVIDNGSGMCkAGF
0 1 K18-ub DNGSGMCkAGFAGDD
1 91 S33-p APRAVFPsIVGRPRH
0 54 K50-ac VMVGMGQkDsyVGDE
0 105 K50-ub VMVGMGQkDsyVGDE
0 402 S52-p VGMGQkDsyVGDEAQ
0 1036 Y53-p GMGQkDsyVGDEAQs
0 12 S60-p yVGDEAQskRGILtL
0 255 K61-ac VGDEAQskRGILtLk
0 119 K61-ub VGDEAQskRGILtLk
0 7 T66-p QskRGILtLkyPIEH
0 5 K68-m1 kRGILtLkyPIEHGI
0 2 Y69-p RGILtLkyPIEHGIV
0 8 T89-p MEKIWHHtFyNELRV
0 851 Y91-p KIWHHtFyNELRVAP
0 2 T106-p EEHPVLLtEAPLNPk
0 78 K113-ub tEAPLNPkANREKMT
0 17 Y143-p IQAVLSLyASGRTTG
0 5 S155-p TTGIVMDsGDGVtHT
0 2 T160-p MDsGDGVtHTVPIyE
0 317 Y166-p VtHTVPIyEGyALPH
0 133 Y169-p TVPIyEGyALPHAIL
0 2 T186-p DLAGRDLtDyLMkIL
0 235 Y188-p AGRDLtDyLMkILTE
0 6 K191-ac DLtDyLMkILTERGy
0 94 K191-ub DLtDyLMkILTERGy
0 830 Y198-p kILTERGysFtttAE
0 22 S199-p ILTERGysFtttAER
0 4 T201-p TERGysFtttAEREI
0 13 T202-p ERGysFtttAEREIV
0 10 T203-p RGysFtttAEREIVR
0 5 K213-ac REIVRDIkEkLCyVA
0 4 K213-ub REIVRDIkEkLCyVA
0 49 K215-ub IVRDIkEkLCyVALD
0 171 Y218-p DIkEkLCyVALDFEQ
0 3 K238-ub ASSSSLEksyELPDG
0 17 S239-p SSSSLEksyELPDGQ
0 36 Y240-p SSSLEksyELPDGQV
0 15 T249-p LPDGQVItIGNERFR
0 1 S265-p PEALFQPsFLGMEsC
0 1 S271-p PsFLGMEsCGIHETT
0 2 K284-ub TTFNSIMkCDVDIRk
0 86 K291-ub kCDVDIRkDLyANtV
0 745 Y294-p VDIRkDLyANtVLSG
0 27 T297-p RkDLyANtVLSGGTT
0 9 K315-ac GIADRMQkEItALAP
0 103 K315-ub GIADRMQkEItALAP
0 8 T318-p DRMQkEItALAPstM
0 9 S323-p EItALAPstMkIkII
0 6 T324-p ItALAPstMkIkIIA
0 11 K326-ac ALAPstMkIkIIAPP
0 135 K326-ub ALAPstMkIkIIAPP
0 9 K328-ac APstMkIkIIAPPER
0 106 K328-ub APstMkIkIIAPPER
0 47 Y362-p MWISKQEyDEsGPSI
0 2 S365-p SKQEyDEsGPSIVHR
  mouse

 
S14-p ALVIDNGsGMCKAGF
K18 DNGsGMCKAGFAGDD
S33-p APRAVFPsIVGRPRH
K50-ac VMVGMGQkDsyVGDE
K50-ub VMVGMGQkDsyVGDE
S52-p VGMGQkDsyVGDEAQ
Y53-p GMGQkDsyVGDEAQs
S60-p yVGDEAQskRGILtL
K61-ac VGDEAQskRGILtLK
K61-ub VGDEAQskRGILtLK
T66-p QskRGILtLKyPIEH
K68 kRGILtLKyPIEHGI
Y69-p RGILtLKyPIEHGIV
T89-p MEKIWHHtFyNELRV
Y91-p KIWHHtFyNELRVAP
T106-p EEHPVLLtEAPLNPk
K113-ub tEAPLNPkANREKMT
Y143-p IQAVLSLyASGRTTG
S155 TTGIVMDSGDGVtHT
T160-p MDSGDGVtHTVPIyE
Y166-p VtHTVPIyEGyALPH
Y169-p TVPIyEGyALPHAIL
T186-p DLAGRDLtDyLMkIL
Y188-p AGRDLtDyLMkILTE
K191-ac DLtDyLMkILTERGy
K191-ub DLtDyLMkILTERGy
Y198-p kILTERGysFtttAE
S199-p ILTERGysFtttAER
T201-p TERGysFtttAEREI
T202-p ERGysFtttAEREIV
T203-p RGysFtttAEREIVR
K213-ac REIVRDIkEkLCyVA
K213 REIVRDIKEkLCyVA
K215-ub IVRDIkEkLCyVALD
Y218-p DIkEkLCyVALDFEQ
K238 ASSSSLEKsyELPDG
S239-p SSSSLEKsyELPDGQ
Y240-p SSSLEKsyELPDGQV
T249-p LPDGQVItIGNERFR
S265 PEALFQPSFLGMESC
S271 PSFLGMESCGIHETT
K284 TTFNSIMKCDVDIRk
K291-ub KCDVDIRkDLyANtV
Y294-p VDIRkDLyANtVLSG
T297-p RkDLyANtVLSGGTT
K315-ac GIADRMQkEItALAP
K315-ub GIADRMQkEItALAP
T318-p DRMQkEItALAPstM
S323-p EItALAPstMkIkII
T324-p ItALAPstMkIkIIA
K326-ac ALAPstMkIkIIAPP
K326-ub ALAPstMkIkIIAPP
K328-ac APstMkIkIIAPPER
K328-ub APstMkIkIIAPPER
Y362 MWISKQEYDEsGPSI
S365-p SKQEYDEsGPSIVHR
  rat

 
S14-p ALVIDNGsGMCKAGF
K18 DNGsGMCKAGFAGDD
S33-p APRAVFPsIVGRPRH
K50 VMVGMGQKDsyVGDE
K50-ub VMVGMGQkDsyVGDE
S52-p VGMGQkDsyVGDEAQ
Y53-p GMGQkDsyVGDEAQS
S60 yVGDEAQSkRGILTL
K61-ac VGDEAQSkRGILTLK
K61-ub VGDEAQSkRGILTLK
T66 QSkRGILTLKYPIEH
K68 kRGILTLKYPIEHGI
Y69 RGILTLKYPIEHGIV
T89 MEKIWHHTFyNELRV
Y91-p KIWHHTFyNELRVAP
T106 EEHPVLLTEAPLNPk
K113-ub TEAPLNPkANREKMT
Y143 IQAVLSLYASGRTTG
S155 TTGIVMDSGDGVTHT
T160 MDSGDGVTHTVPIyE
Y166-p VTHTVPIyEGyALPH
Y169-p TVPIyEGyALPHAIL
T186 DLAGRDLTDyLMkIL
Y188-p AGRDLTDyLMkILTE
K191 DLTDyLMKILTERGy
K191-ub DLTDyLMkILTERGy
Y198-p kILTERGysFtTTAE
S199-p ILTERGysFtTTAER
T201-p TERGysFtTTAEREI
T202 ERGysFtTTAEREIV
T203 RGysFtTTAEREIVR
K213 REIVRDIKEkLCyVA
K213 REIVRDIKEkLCyVA
K215-ub IVRDIKEkLCyVALD
Y218-p DIKEkLCyVALDFEQ
K238 ASSSSLEKsyELPDG
S239-p SSSSLEKsyELPDGQ
Y240-p SSSLEKsyELPDGQV
T249 LPDGQVITIGNERFR
S265 PEALFQPSFLGMESC
S271 PSFLGMESCGIHETT
K284 TTFNSIMKCDVDIRK
K291 KCDVDIRKDLyANTV
Y294-p VDIRKDLyANTVLSG
T297 RKDLyANTVLSGGTT
K315-ac GIADRMQkEITALAP
K315-ub GIADRMQkEITALAP
T318 DRMQkEITALAPSTM
S323 EITALAPSTMkIkII
T324 ITALAPSTMkIkIIA
K326-ac ALAPSTMkIkIIAPP
K326-ub ALAPSTMkIkIIAPP
K328 APSTMkIKIIAPPER
K328-ub APSTMkIkIIAPPER
Y362-p MWISKQEyDESGPSI
S365 SKQEyDESGPSIVHR
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