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ACTG1 (human)

Overview ACTG1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: filamentous actin; cytoskeleton; myofibril; axon; cytosol Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; protein kinase binding; ATP binding Biological Process: intercellular junction assembly and maintenance; axon guidance; sarcomere organization; blood coagulation; cell motility; response to calcium ion Reference #:  P63261 (UniProtKB) Alt. Names/Synonyms: ACT; ACTB; ACTG; ACTG1; Actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed; actin, gamma 1; cytoskeletal gamma-actin; DFNA20; DFNA26; Gamma-actin Gene Symbols: ACTG1 Molecular weight: 41,793 Da Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states CST Pathways:  Death Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ACTG1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S14	ALVIDNGSGMCkAGF
0	1		K18-u	DNGSGMCkAGFAGDD
1	89		S33-p	APRAVFPsIVGRPRH
0	53		K50-a	VMVGMGQkDsyVGDE
0	105		K50-u	VMVGMGQkDsyVGDE
0	406		S52-p	VGMGQkDsyVGDEAQ
0	1057		Y53-p	GMGQkDsyVGDEAQs
0	9		S60-p	yVGDEAQskRGILtL
0	255		K61-a	VGDEAQskRGILtLk
0	119		K61-u	VGDEAQskRGILtLk
0	4		T66-p	QskRGILtLkyPIEH
0	4		K68-m1	kRGILtLkyPIEHGI
0	3		Y69-p	RGILtLkyPIEHGIV
0	8		T89-p	MEKIWHHtFyNELRV
0	853		Y91-p	KIWHHtFyNELRVAP
0	78		K113-u	TEAPLNPkANREKMT
0	17		Y143-p	IQAVLSLyASGRTTG
0	5		S155-p	TTGIVMDsGDGVtHT
0	2		T160-p	MDsGDGVtHTVPIyE
0	317		Y166-p	VtHTVPIyEGyALPH
0	132		Y169-p	TVPIyEGyALPHAIL
0	2		T186-p	DLAGRDLtDyLMkIL
0	227		Y188-p	AGRDLtDyLMkILTE
0	6		K191-a	DLtDyLMkILTERGy
0	94		K191-u	DLtDyLMkILTERGy
0	851		Y198-p	kILTERGysFtttAE
0	23		S199-p	ILTERGysFtttAER
0	4		T201-p	TERGysFtttAEREI
0	13		T202-p	ERGysFtttAEREIV
0	7		T203-p	RGysFtttAEREIVR
0	5		K213-a	REIVRDIkEkLCyVA
0	4		K213-u	REIVRDIkEkLCyVA
0	49		K215-u	IVRDIkEkLCyVALD
0	172		Y218-p	DIkEkLCyVALDFEQ
0	3		K238-u	ASSSSLEksyELPDG
0	12		S239-p	SSSSLEksyELPDGQ
0	36		Y240-p	SSSLEksyELPDGQV
0	14		T249-p	LPDGQVItIGNERFR
0	2		K284-u	TTFNSIMkCDVDIRk
0	86		K291-u	kCDVDIRkDLyANtV
0	765		Y294-p	VDIRkDLyANtVLSG
0	25		T297-p	RkDLyANtVLSGGTT
0	41		Y306-p	LSGGTTMyPGIADRM
0	9		K315-a	GIADRMQkEItALAP
0	103		K315-u	GIADRMQkEItALAP
0	5		T318-p	DRMQkEItALAPstM
0	7		S323-p	EItALAPstMkIkII
0	4		T324-p	ItALAPstMkIkIIA
0	10		K326-a	ALAPstMkIkIIAPP
0	135		K326-u	ALAPstMkIkIIAPP
0	8		K328-a	APstMkIkIIAPPER
0	106		K328-u	APstMkIkIIAPPER
0	46		Y362-p	MWISKQEyDEsGPSI
0	2		S365-p	SKQEyDEsGPSIVHR

	mouse
S14-p	ALVIDNGsGMCKAGF
K18	DNGsGMCKAGFAGDD
S33-p	APRAVFPsIVGRPRH
K50-a	VMVGMGQkDsyVGDE
K50-u	VMVGMGQkDsyVGDE
S52-p	VGMGQkDsyVGDEAQ
Y53-p	GMGQkDsyVGDEAQs
S60-p	yVGDEAQskRGILtL
K61-a	VGDEAQskRGILtLK
K61-u	VGDEAQskRGILtLK
T66-p	QskRGILtLKyPIEH
K68	kRGILtLKyPIEHGI
Y69-p	RGILtLKyPIEHGIV
T89-p	MEKIWHHtFyNELRV
Y91-p	KIWHHtFyNELRVAP
K113-u	TEAPLNPkANREKMT
Y143-p	IQAVLSLyASGRTTG
S155	TTGIVMDSGDGVtHT
T160-p	MDSGDGVtHTVPIyE
Y166-p	VtHTVPIyEGyALPH
Y169-p	TVPIyEGyALPHAIL
T186-p	DLAGRDLtDyLMkIL
Y188-p	AGRDLtDyLMkILTE
K191-a	DLtDyLMkILTERGy
K191-u	DLtDyLMkILTERGy
Y198-p	kILTERGysFtttAE
S199-p	ILTERGysFtttAER
T201-p	TERGysFtttAEREI
T202-p	ERGysFtttAEREIV
T203-p	RGysFtttAEREIVR
K213-a	REIVRDIkEkLCyVA
K213	REIVRDIKEkLCyVA
K215-u	IVRDIkEkLCyVALD
Y218-p	DIkEkLCyVALDFEQ
K238	ASSSSLEKsyELPDG
S239-p	SSSSLEKsyELPDGQ
Y240-p	SSSLEKsyELPDGQV
T249-p	LPDGQVItIGNERFR
K284	TTFNSIMKCDVDIRk
K291-u	KCDVDIRkDLyANtV
Y294-p	VDIRkDLyANtVLSG
T297-p	RkDLyANtVLSGGTT
Y306	LSGGTTMYPGIADRM
K315-a	GIADRMQkEItALAP
K315-u	GIADRMQkEItALAP
T318-p	DRMQkEItALAPstM
S323-p	EItALAPstMkIkII
T324-p	ItALAPstMkIkIIA
K326-a	ALAPstMkIkIIAPP
K326-u	ALAPstMkIkIIAPP
K328-a	APstMkIkIIAPPER
K328-u	APstMkIkIIAPPER
Y362	MWISKQEYDEsGPSI
S365-p	SKQEYDEsGPSIVHR

	rat
S14	ALVIDNGSGMCKAGF
K18	DNGSGMCKAGFAGDD
S33-p	APRAVFPsIVGRPRH
K50	VMVGMGQKDsyVGDE
K50-u	VMVGMGQkDsyVGDE
S52-p	VGMGQkDsyVGDEAQ
Y53-p	GMGQkDsyVGDEAQS
S60	yVGDEAQSkRGILTL
K61-a	VGDEAQSkRGILTLK
K61-u	VGDEAQSkRGILTLK
T66	QSkRGILTLKYPIEH
K68	kRGILTLKYPIEHGI
Y69	RGILTLKYPIEHGIV
T89	MEKIWHHTFyNELRV
Y91-p	KIWHHTFyNELRVAP
K113-u	TEAPLNPkANREKMT
Y143	IQAVLSLYASGRTTG
S155	TTGIVMDSGDGVTHT
T160	MDSGDGVTHTVPIyE
Y166-p	VTHTVPIyEGyALPH
Y169-p	TVPIyEGyALPHAIL
T186	DLAGRDLTDyLMkIL
Y188-p	AGRDLTDyLMkILTE
K191	DLTDyLMKILTERGy
K191-u	DLTDyLMkILTERGy
Y198-p	kILTERGysFtTTAE
S199-p	ILTERGysFtTTAER
T201-p	TERGysFtTTAEREI
T202	ERGysFtTTAEREIV
T203	RGysFtTTAEREIVR
K213	REIVRDIKEkLCyVA
K213	REIVRDIKEkLCyVA
K215-u	IVRDIKEkLCyVALD
Y218-p	DIKEkLCyVALDFEQ
K238	ASSSSLEKsyELPDG
S239-p	SSSSLEKsyELPDGQ
Y240-p	SSSLEKsyELPDGQV
T249	LPDGQVITIGNERFR
K284	TTFNSIMKCDVDIRK
K291	KCDVDIRKDLyANTV
Y294-p	VDIRKDLyANTVLSG
T297	RKDLyANTVLSGGTT
Y306	LSGGTTMYPGIADRM
K315-a	GIADRMQkEITALAP
K315-u	GIADRMQkEITALAP
T318	DRMQkEITALAPSTM
S323	EITALAPSTMkIkII
T324	ITALAPSTMkIkIIA
K326-a	ALAPSTMkIkIIAPP
K326-u	ALAPSTMkIkIIAPP
K328	APSTMkIKIIAPPER
K328-u	APSTMkIkIIAPPER
Y362	MWISKQEYDESGPSI
S365	SKQEYDESGPSIVHR

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