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TUBA1C (human)

Overview TUBA1C Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: microtubule cytoskeleton; microtubule; cytoplasmic microtubule Molecular Function: GTPase activity; GTP binding; structural molecule activity Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; cytoskeleton-dependent intracellular transport; microtubule-based movement; microtubule-based process Reference #:  Q9BQE3 (UniProtKB) Alt. Names/Synonyms: Alpha-tubulin 6; bcm948; MGC10851; MGC14580; TBA1C; TUBA1C; TUBA6; Tubulin alpha-1C chain; Tubulin alpha-6 chain; tubulin, alpha 1c; tubulin, alpha 6 Gene Symbols: TUBA1C Molecular weight: 49,895 Da Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TUBA1C

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	Sites Implicated In
cell motility, altered: S165‑p cytoskeletal reorganization: S165‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	16		K40-a	DGQMPSDktIGGGDD
0	10		K40-u	DGQMPSDktIGGGDD
0	2		T41-p	GQMPSDktIGGGDDs
0	45		S48-p	tIGGGDDsFNtFFSE
0	14		T51-p	GGDDsFNtFFSETGA
0	5		K60-a	FSETGAGkHVPRAVF
0	103		K60-u	FSETGAGkHVPRAVF
0	12		T73-p	VFVDLEPtVIDEVRt
0	13		T80-p	tVIDEVRtGtYRQLF
0	102		T82-p	IDEVRtGtYRQLFHP
0	4		K96-a	PEQLITGkEDAANNy
0	142		K96-u	PEQLITGkEDAANNy
0	588		Y103-p	kEDAANNyARGHytI
0	39		Y108-p	NNyARGHytIGkEII
0	6		T109-p	NyARGHytIGkEIID
0	8		K112-a	RGHytIGkEIIDLVL
0	101		K112-u	RGHytIGkEIIDLVL
0	6		K124-a	LVLDRIRkLADQCTG
0	24		K124-u	LVLDRIRkLADQCTG
1	4		S158-p	SLLMERLsVDyGkks
0	51		Y161-p	MERLsVDyGkkskLE
0	29		K163-a	RLsVDyGkkskLEFS
0	86		K163-u	RLsVDyGkkskLEFS
0	28		K164-u	LsVDyGkkskLEFSI
1	1		S165-p	sVDyGkkskLEFSIY
0	22		K166-u	VDyGkkskLEFSIYP
0	29		Y185-p	STAVVEPyNSILttH
0	15		T190-p	EPyNSILttHTTLEH
0	8		T191-p	PyNSILttHTTLEHS
0	386		Y210-p	MVDNEAIyDICRRNL
0	33		T223-p	NLDIERPtytNLNRL
0	241		Y224-p	LDIERPtytNLNRLI
0	2		T225-p	DIERPtytNLNRLIs
0	27		S232-p	tNLNRLIsQIVSSIT
0	5		Y262-p	FQTNLVPyPRIHFPL
0	19		T271-p	RIHFPLAtyAPVIsA
0	459		Y272-p	IHFPLAtyAPVIsAE
0	4		S277-p	AtyAPVIsAEkAyHE
0	3		K280-a	APVIsAEkAyHEQLt
0	2		K280-u	APVIsAEkAyHEQLt
0	14		Y282-p	VIsAEkAyHEQLtVA
0	2		T287-p	kAyHEQLtVAEITNA
0	49		K304-u	EPANQMVkCDPRHGk
0	19		K311-a	kCDPRHGkyMACCLL
0	79		K311-u	kCDPRHGkyMACCLL
0	69		Y312-p	CDPRHGkyMACCLLy
0	170		Y319-p	yMACCLLyRGDVVPk
0	4		K326-a	yRGDVVPkDVNAAIA
0	119		K326-u	yRGDVVPkDVNAAIA
0	14		T334-p	DVNAAIAtIktkRTI
0	1		K336-a	NAAIAtIktkRTIQF
0	132		K336-u	NAAIAtIktkRTIQF
0	17		T337-p	AAIAtIktkRTIQFV
0	35		K338-u	AIAtIktkRTIQFVD
0	26		K352-a	DWCPTGFkVGINyQP
0	27		K352-u	DWCPTGFkVGINyQP
0	566		Y357-p	GFkVGINyQPPtVVP
0	82		T361-p	GINyQPPtVVPGGDL
0	156		K370-u	VPGGDLAkVQRAVCM
0	10		K394-a	AWARLDHkFDLMyAk
0	121		K394-u	AWARLDHkFDLMyAk
0	420		Y399-p	DHkFDLMyAkRAFVH
0	19		K401-a	kFDLMyAkRAFVHWY
0	117		K401-u	kFDLMyAkRAFVHWY
0	1		K430-u	EDMAALEkDyEEVGA
0	69		Y432-p	MAALEkDyEEVGADs
0	24		S439-p	yEEVGADsADGEDEG
0	81		Y449-p	GEDEGEEy_______

	mouse
K40-a	DGQMPSDktIGGGDD
K40-u	DGQMPSDktIGGGDD
T41-p	GQMPSDktIGGGDDs
S48-p	tIGGGDDsFNtFFSE
T51-p	GGDDsFNtFFSETGA
K60-a	FSETGAGkHVPRAVF
K60-u	FSETGAGkHVPRAVF
T73-p	VFVDLEPtVIDEVRT
T80	tVIDEVRTGtYRQLF
T82-p	IDEVRTGtYRQLFHP
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYtI
Y108	NNyARGHYtIGkEII
T109-p	NyARGHYtIGkEIID
K112	RGHYtIGKEIIDLVL
K112-u	RGHYtIGkEIIDLVL
K124-a	LVLDRIRkLADQCTG
K124	LVLDRIRKLADQCTG
S158-p	SLLMERLsVDyGkks
Y161-p	MERLsVDyGkkskLE
K163-a	RLsVDyGkkskLEFS
K163-u	RLsVDyGkkskLEFS
K164-u	LsVDyGkkskLEFSI
S165-p	sVDyGkkskLEFSIY
K166-u	VDyGkkskLEFSIYP
Y185	STAVVEPYNSILTTH
T190	EPYNSILTTHTTLEH
T191	PYNSILTTHTTLEHS
Y210-p	MVDNEAIyDICRRNL
T223-p	NLDIERPtytNLNRL
Y224-p	LDIERPtytNLNRLI
T225-p	DIERPtytNLNRLIs
S232-p	tNLNRLIsQIVSSIT
Y262	FQTNLVPYPRIHFPL
T271	RIHFPLATyAPVIsA
Y272-p	IHFPLATyAPVIsAE
S277-p	ATyAPVIsAEKAYHE
K280	APVIsAEKAYHEQLT
K280	APVIsAEKAYHEQLT
Y282	VIsAEKAYHEQLTVA
T287	KAYHEQLTVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKYMACCLL
K311-u	kCDPRHGkYMACCLL
Y312	CDPRHGkYMACCLLy
Y319-p	YMACCLLyRGDVVPk
K326	yRGDVVPKDVNAAIA
K326-u	yRGDVVPkDVNAAIA
T334-p	DVNAAIAtIktkRTI
K336	NAAIAtIKtkRTIQF
K336-u	NAAIAtIktkRTIQF
T337-p	AAIAtIktkRTIQFV
K338-u	AIAtIktkRTIQFVD
K352-a	DWCPTGFkVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPtVVP
T361-p	GINyQPPtVVPGGDL
K370-u	VPGGDLAkVQRAVCM
K394	AWARLDHKFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
K430	EDMAALEKDyEEVGA
Y432-p	MAALEKDyEEVGADs
S439-p	yEEVGADsAEGDDEG
Y449	GDDEGEEY_______

	rat
K40	DGQMPSDKTIGGGDD
K40	DGQMPSDKTIGGGDD
T41	GQMPSDKTIGGGDDS
S48	TIGGGDDSFNTFFSE
T51	GGDDSFNTFFSETGA
K60	FSETGAGKHVPRAVF
K60-u	FSETGAGkHVPRAVF
T73	VFVDLEPTVIDEVRT
T80	TVIDEVRTGTYRQLF
T82	IDEVRTGTYRQLFHP
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYTI
Y108	NNyARGHYTIGKEII
T109	NyARGHYTIGKEIID
K112	RGHYTIGKEIIDLVL
K112	RGHYTIGKEIIDLVL
K124	LVLDRIRKLADQCTG
K124	LVLDRIRKLADQCTG
S158	SLLMERLSVDYGkkS
Y161	MERLSVDYGkkSKLE
K163-a	RLSVDYGkkSKLEFS
K163-u	RLSVDYGkkSKLEFS
K164-u	LSVDYGkkSKLEFSI
S165	SVDYGkkSKLEFSIY
K166	VDYGkkSKLEFSIYP
Y185	STAVVEPYNSILTTH
T190	EPYNSILTTHTTLEH
T191	PYNSILTTHTTLEHS
Y210	MVDNEAIYDICRRNL
T223	NLDIERPTyTNLNRL
Y224-p	LDIERPTyTNLNRLI
T225	DIERPTyTNLNRLIs
S232-p	TNLNRLIsQIVSSIT
Y262	FQTNLVPYPRIHFPL
T271	RIHFPLATyAPVISA
Y272-p	IHFPLATyAPVISAE
S277	ATyAPVISAEKAYHE
K280	APVISAEKAYHEQLT
K280	APVISAEKAYHEQLT
Y282	VISAEKAYHEQLTVA
T287	KAYHEQLTVAEITNA
K304	EPANQMVKCDPRHGk
K311	KCDPRHGKyMACCLL
K311-u	KCDPRHGkyMACCLL
Y312-p	CDPRHGkyMACCLLy
Y319-p	yMACCLLyRGDVVPk
K326	yRGDVVPKDVNAAIA
K326-u	yRGDVVPkDVNAAIA
T334-p	DVNAAIAtIkTkRTI
K336-a	NAAIAtIkTkRTIQF
K336-u	NAAIAtIkTkRTIQF
T337	AAIAtIkTkRTIQFV
K338-u	AIAtIkTkRTIQFVD
K352	DWCPTGFKVGINYQP
K352	DWCPTGFKVGINYQP
Y357	GFKVGINYQPPTVVP
T361	GINYQPPTVVPGGDL
R370	VPGGDLARVQRAVCM
K394-a	AWARLDHkFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
K430	EDMAALEKDYEEVGA
Y432	MAALEKDYEEVGADS
S439	YEEVGADSAEGDDEG
Y449	GDDEGEEY_______

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