Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: lysosomal lumen; protein complex; focal adhesion; integral to plasma membrane; Golgi lumen; cytoplasm; plasma membrane; external side of plasma membrane
Molecular Function: protein C-terminus binding; protein binding; cytoskeletal protein binding; glycoprotein binding
Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; myoblast development; response to cAMP; wound healing; glycosaminoglycan metabolic process; striated muscle cell development; response to toxin; response to glucocorticoid stimulus; lipoprotein metabolic process; Wnt receptor signaling pathway through beta-catenin; Sertoli cell development; chondroitin sulfate metabolic process; odontogenesis; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; response to hydrogen peroxide; ureteric bud development; carbohydrate metabolic process; retinoid metabolic process; inflammatory response; response to calcium ion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.