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Protein Page:
syndecan-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
syndecan-1 Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Extracellular matrix; Membrane protein, integral
Cellular Component: lysosomal lumen; focal adhesion; protein complex; integral to plasma membrane; Golgi lumen; cytoplasm; plasma membrane; external side of plasma membrane
Molecular Function: protein C-terminus binding; protein binding; cytoskeletal protein binding; glycoprotein binding
Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; response to cAMP; myoblast development; glycosaminoglycan metabolic process; wound healing; striated muscle cell development; response to toxin; response to glucocorticoid stimulus; lipoprotein metabolic process; Wnt receptor signaling pathway through beta-catenin; Sertoli cell development; odontogenesis; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; response to hydrogen peroxide; ureteric bud development; carbohydrate metabolic process; response to calcium ion; retinoid metabolic process; inflammatory response
Reference #:  P18827 (UniProtKB)
Alt. Names/Synonyms: CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; SDC1; SYND1; syndecan; syndecan 1; syndecan proteoglycan 1; Syndecan-1
Gene Symbols: SDC1
Molecular weight: 32,462 Da
Basal Isoelectric point: 4.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

syndecan-1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell adhesion, altered: Y309‑p
cytoskeletal reorganization: Y309‑p
molecular association, regulation: Y309‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T61-ga DITLSQQtPSTWKDT
0 1 T72-ga WKDTQLLtAIPtsPE
0 1 T76-ga QLLtAIPtsPEPtGL
0 1 S77-ga LLtAIPtsPEPtGLE
0 1 T81-ga IPtsPEPtGLEATAA
0 1 T122-ga TAREQEAtPRPRETT
0 1 T164-ga MQPGHHEtstPAGPs
0 1 S165-ga QPGHHEtstPAGPsQ
0 1 T166-ga PGHHEtstPAGPsQA
0 1 S171-ga tstPAGPsQADLHtP
0 1 T177-ga PsQADLHtPHtEDGG
0 1 T180-ga ADLHtPHtEDGGPsA
0 1 S186-ga HtEDGGPsAtERAAE
0 1 T188-ga EDGGPsAtERAAEDG
0 1 T240-ga SPVDQGAtGASQGLL
0 9 K280-u FMLYRMKkkDEGsys
0 33 K281-u MLYRMKkkDEGsysL
1 1 S285-p MKkkDEGsysLEEPk
1 27 Y286-p KkkDEGsysLEEPkQ
0 1 S287-p kkDEGsysLEEPkQA
0 20 K292-u sysLEEPkQANGGAy
1 16 Y299-p kQANGGAyQkPTkQE
0 35 K301-u ANGGAyQkPTkQEEF
0 29 K304-u GAyQkPTkQEEFyA_
1 158 Y309-p PTkQEEFyA______
  mouse

 
T60 PDTLSRQTPSTWKDV
T71 WKDVWLLTATPTAPE
T75 WLLTATPTAPEPTSS
A76 LLTATPTAPEPTSSN
T80 TPTAPEPTSSNTETA
T123 RDKEKEVTTRPRETV
T165 MQPGLHETSAPTAPG
S166 QPGLHETSAPTAPGQ
A167 PGLHETSAPTAPGQP
- gap
- gap
- gap
S187 RVEGGGTSVIKEVVE
I189 EGGGTSVIKEVVEDG
T241 PPVDEGATGASQSLL
K281 FMLYRMKKkDEGsYS
K282-u MLYRMKKkDEGsYSL
S286-p MKKkDEGsYSLEEPK
Y287 KKkDEGsYSLEEPKQ
S288 KkDEGsYSLEEPKQA
K293 sYSLEEPKQANGGAY
Y300 KQANGGAYQkPTKQE
K302-u ANGGAYQkPTKQEEF
K305 GAYQkPTKQEEFyA_
Y310-p PTKQEEFyA______
  rat

 
T61 DMTLSRQTPSTWKDV
T72 WKDVWLLTATPTAPE
T76 WLLTATPTAPEPTSR
A77 LLTATPTAPEPTSRD
T81 TPTAPEPTSRDTEAT
T124 RDKEKEATTRPRETT
T167 VQPGLHETLAPTAPG
L168 QPGLHETLAPTAPGQ
A169 PGLHETLAPTAPGQP
- gap
- gap
- gap
S189 SVEDGGTSVIKEVVE
I191 EDGGTSVIKEVVEDE
T243 SPVDEGATGASQGLL
K283 FMLYRMKKKDEGSYS
K284 MLYRMKKKDEGSYSL
S288 MKKKDEGSYSLEEPK
Y289 KKKDEGSYSLEEPKQ
S290 KKDEGSYSLEEPKQA
K295 SYSLEEPKQANGGAY
Y302 KQANGGAYQKPTKQE
K304 ANGGAYQKPTKQEEF
K307 GAYQKPTKQEEFyA_
Y312-p PTKQEEFyA______
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