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Protein Page:
SENP3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SENP3 Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Binds to SUMO1 and SUMO3. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm. Belongs to the peptidase C48 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.68; Protease; Nucleolus; Ubiquitin-specific protease; EC 3.4.22.-
Cellular Component: cytoplasm; nucleolus
Molecular Function: protein binding; ubiquitin-specific protease activity
Biological Process: proteolysis
Reference #:  Q9H4L4 (UniProtKB)
Alt. Names/Synonyms: DKFZp586K0919; DKFZp762A152; SENP3; Sentrin-specific protease 3; sentrin/SUMO-specific protease 3; Sentrin/SUMO-specific protease SENP3; SMT3IP1; SSP3; SUMO-1-specific protease 3; SUMO1/sentrin/SMT3 specific peptidase 3; SUMO1/sentrin/SMT3 specific protease 3; SUSP3
Gene Symbols: SENP3
Molecular weight: 65,010 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SENP3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y24-p GPGIPPAyssPRRER
0 9 S25-p PGIPPAyssPRRERL
0 18 S26-p GIPPAyssPRRERLR
0 2 K43-ub PPPKPRLksGGGFGP
0 2 S44-p PPKPRLksGGGFGPD
0 1 S54-p GFGPDPGsGTTVPAR
0 1 S69-p RLPVPRPsFDAsAsE
0 5 S73-p PRPsFDAsAsEEEEE
0 5 S75-p PsFDAsAsEEEEEEE
0 2 R110 SQLGTSQRPRPSRPT
0 1 P111 QLGTSQRPRPSRPTH
0 2 T117 RPRPSRPTHRkTCSQ
0 1 K120-ac PSRPTHRkTCSQRRR
0 50 S169-p AHPKNHLsPQQGGAt
0 16 T176-p sPQQGGAtPQVPsPC
0 42 S181-p GAtPQVPsPCCRFDs
0 14 S188-p sPCCRFDsPRGPPPP
0 15 S212-p AEDGVRGsPPVPSGP
0 1 S217 RGsPPVPSGPPMEED
0 7 T229-p EEDGLRWtPKsPLDP
0 114 S232-p GLRWtPKsPLDPDsG
0 4 S238-p KsPLDPDsGLLsCTL
0 3 S242-p DPDsGLLsCTLPNGF
0 3 S307-p GEKAGQHsPLREEHV
0 7 T353-p IFQQEFStPSRKGLV
0 2 K446-ub DGVKRWTkNVDIFNK
0 2 T477-p SVDVRRRtITYFDsQ
0 3 S483-p RtITYFDsQRTLNRR
0 1 Y498-p CPKHIAKyLQAEAVK
  mouse

 
Y22 PPGPGTTYSNPRRER
S23 PGPGTTYSNPRRERL
N24 GPGTTYSNPRRERLR
K41-ub LPPKPRLkSGGGFGP
S42 PPKPRLkSGGGFGPD
S52 GFGPDPGSGTTVPTR
S67-p RLPAPRPsFDAsAsE
S71-p PRPsFDAsAsEEEEE
S73-p PsFDAsAsEEEEEEE
R104-m1 GQLGASQrsRALRPs
S105-p QLGASQrsRALRPsH
S111-p rsRALRPsHRKTCSQ
K114 ALRPsHRKTCSQRRR
S163-p AHPKNHLsPQEGGAt
T170-p sPQEGGAtPQVPsPC
S175-p GAtPQVPsPCCRFDs
S182-p sPCCRFDsPRGLPPP
S206-p AEDGMRGsPPVPsGP
S211-p RGsPPVPsGPPMEED
T223-p EEDGLRWtPKsPLDP
S226-p GLRWtPKsPLDPDsG
S232-p KsPLDPDsGLLsCTL
S236-p DPDsGLLsCTLPNGF
S301 GEKAGQHSPLREEHV
T347 IFQQEFSTPSRKSLV
K440 DGVKRWTKNVDIFNK
T471-p SVDVRRRtITYFDsQ
S477-p RtITYFDsQRTLNRR
Y492 CPKHIAKYLQAEAVK
  rat

 
Y21 PPGPGTTYSNPRRER
S22 PGPGTTYSNPRRERL
N23 GPGTTYSNPRRERLR
K40 LPPKPRLKSGGGFGP
S41 PPKPRLKSGGGFGPD
S51 GFGPDPGSGTTVPTR
S66 RLPGPRPSFDASASE
S70 PRPSFDASASEEEEE
S72 PSFDASASEEEEEEE
R103 GQLGTSQRPRALRPS
P104 QLGTSQRPRALRPSH
S110 RPRALRPSHRKTCSQ
K113 ALRPSHRKTCSQRRR
S162 AHPKNHLSPQEGGAT
T169 SPQEGGATPQVPSPC
S174 GATPQVPSPCCRFDS
S181 SPCCRFDSPRGLPPP
S205-p AEDGMRGsPPVPSGP
S210 RGsPPVPSGPPMEED
T222 EEDGLRWTPKsPLDP
S225-p GLRWTPKsPLDPDSG
S231 KsPLDPDSGLLsCTL
S235-p DPDSGLLsCTLPNGF
S300 GEKAGQHSPLREEHV
T346 IFQQEFSTPSRKSLV
K439 DGVKRWTKNVDIFNK
T470 SVDVRRRTITYFDSQ
S476 RTITYFDSQRTLNRR
Y491 CPKHIAKYLQAEAVK
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