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Protein Page:
RPS26 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RPS26 Defects in RPS26 are the cause of Diamond-Blackfan anemia type 10 (DBA10). It is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S26e family. Note: This description may include information from UniProtKB.
Protein type: Ribosomal protein; Translation
Cellular Component: small ribosomal subunit; membrane; cytoplasm; nucleolus; cytosol
Molecular Function: mRNA binding; protein binding; structural constituent of ribosome
Biological Process: SRP-dependent cotranslational protein targeting to membrane; translation; viral reproduction; translational termination; viral infectious cycle; mRNA metabolic process; cellular protein metabolic process; negative regulation of RNA splicing; translational elongation; RNA metabolic process; mRNA catabolic process, nonsense-mediated decay; translational initiation; viral transcription; gene expression
Reference #:  P62854 (UniProtKB)
Alt. Names/Synonyms: 40S ribosomal protein S26; DBA10; MGC104292; ribosomal protein S26; RPS26; RS26
Gene Symbols: RPS26
Molecular weight: 13,015 Da
Basal Isoelectric point: 11.01  Predict pI for various phosphorylation states
Select Structure to View Below

RPS26

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S54-p AAAVRDIsEAsVFDA
0 1 S57-p VRDIsEAsVFDAYVL
0 3 K66-ac FDAYVLPkLYVkLHY
0 43 K66-ub FDAYVLPkLYVkLHY
0 7 K70-ub VLPkLYVkLHYCVSC
0 1 K82-ac VSCAIHSkVVRNRSR
0 4 T96-p REARKDRtPPPRFRP
0 1 K113-ac AAPRPPPkPM_____
  mouse

 
S54-p AAAVRDIsEASVFDA
S57 VRDIsEASVFDAYVL
K66-ac FDAYVLPkLYVkLHY
K66-ub FDAYVLPkLYVkLHY
K70-ub VLPkLYVkLHYCVSC
K82 VSCAIHSKVVRNRSR
T96-p REARKDRtPPPRFRP
K113 AAPRPPPKPM_____
  rat

 
S54 AAAVRDISEASVFDA
S57 VRDISEASVFDAYVL
K66 FDAYVLPKLYVKLHY
K66 FDAYVLPKLYVKLHY
K70 VLPKLYVKLHYCVSC
K82 VSCAIHSKVVRNRSR
T96 REARKDRTPPPRFRP
K113 AAPRPPPKPM_____
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