a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; EC 220.127.116.11; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family
Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; ATP binding
Biological Process: apoptosis; mitotic cell cycle checkpoint; cytokinesis; negative regulation of transcription from RNA polymerase II promoter; response to osmotic stress; endomitotic cell cycle; protein amino acid phosphorylation; cytoplasmic microtubule organization and biogenesis; response to reactive oxygen species; response to radiation; protein kinase B signaling cascade; S phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cell division; response to DNA damage stimulus; cell cycle checkpoint; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.