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Protein Page:
PLK3 (human)

Overview
PLK3 a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.21; Protein kinase, Other; Other group; PLK family
Cellular Component: centrosome; Golgi stack; cell soma; dendrite; cytoplasm; nucleolus; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; ATP binding
Biological Process: apoptosis; mitotic cell cycle checkpoint; cytokinesis; negative regulation of transcription from RNA polymerase II promoter; response to osmotic stress; endomitotic cell cycle; protein amino acid phosphorylation; cytoplasmic microtubule organization and biogenesis; response to reactive oxygen species; response to radiation; protein kinase B signaling cascade; S phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; cell cycle checkpoint; response to DNA damage stimulus; regulation of cell division; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  Q9H4B4 (UniProtKB)
Alt. Names/Synonyms: CNK; cytokine-inducible kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; FNK; PLK-3; PLK3; Polo-like kinase 3; polo-like kinase 3 (Drosophila); PRK; Proliferation-related kinase; Serine/threonine-protein kinase PLK3
Gene Symbols: PLK3
Molecular weight: 71,629 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLK3

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y136-p FEDADNIyIFLELCS
0 1 T194-p KLGNFFItENMELKV
0 1 S369 AQERDEVSGLVSGLM
0 1 S379 VSGLMRTSVGHQDAR
0 1 T503-p ALSANRKtVHyNPTs
0 1 Y506-p ANRKtVHyNPTsTKH
0 1 S510-p tVHyNPTsTKHFsFS
0 1 S515-p PTsTKHFsFSVGAVP
0 1 T614-p ARNRSACtyLASHLR
0 1 Y615-p RNRSACtyLASHLRQ
  mouse

► Hide Isoforms
 
Y137 FEDADNIYIFLELCS
T195 KLGNFFITDNMELKV
S371 SEDQDNVSCLAPVVS
- gap
T488 ALSANRKTVHYNPTS
Y491 ANRKTVHYNPTSTKH
S495 TVHYNPTSTKHFSFS
S500 PTSTKHFSFSMGSVP
T599 ARNRSACTYLASHLR
Y600 RNRSACTYLASHLRQ
  PLK3 iso2  
Y137 FEDADNIYIFLELCS
T195 KLGNFFITDNMELKV
S371-p SEDQDNVsCLVSGLM
S381-p VSGLMRTsIGHPDVR
T505 ALSANRKTVHYNPTS
Y508 ANRKTVHYNPTSTKH
S512 TVHYNPTSTKHFSFS
S517 PTSTKHFSFSMGSVP
T616 ARNRSACTYLASHLR
Y617 RNRSACTYLASHLRQ
  rat

 
Y136 FEDADNIYIFLELCS
T194 KLGNFFITDNMELKV
S370 SEEQDNVSCLVSGLM
S380 VSGLMRTSIGHPDVR
T504 ALSANRKTVHYNPTS
Y507 ANRKTVHYNPTSTKH
S511 TVHYNPTSTKHFSFS
S516 PTSTKHFSFSVGSVP
T615 ARNRSACTYLASHLR
Y616 RNRSACTYLASHLRQ
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