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PLK3
a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.21; Other group; PLK family |
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Cellular Component: centrosome; Golgi stack; cell soma; cytoplasm; dendrite; nucleolus; nucleus
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Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; ATP binding
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Biological Process: apoptosis; cytokinesis; negative regulation of transcription from RNA polymerase II promoter; endomitotic cell cycle; response to osmotic stress; protein amino acid phosphorylation; response to reactive oxygen species; response to radiation; protein kinase B signaling cascade; S phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; response to DNA damage stimulus; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
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Reference #:
Q9H4B4 (UniProtKB)
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| Alt. Names/Synonyms: CNK; cytokine-inducible kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; FNK; PLK-3; PLK3; Polo-like kinase 3; polo-like kinase 3 (Drosophila); PRK; Proliferation-related kinase; Serine/threonine-protein kinase PLK3 |
| Gene Symbols: PLK3 |
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Molecular weight: 71,629 Da
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Basal Isoelectric point: 9.28
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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