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Protein Page:
PSMB6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMB6 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.25.1; Proteasome complex
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: nucleoplasm; proteasome core complex; nucleus; cytosol
Molecular Function: threonine endopeptidase activity; endopeptidase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Reference #:  P28072 (UniProtKB)
Alt. Names/Synonyms: DELTA; LMPY; Macropain delta chain; MGC5169; Multicatalytic endopeptidase complex delta chain; proteasome (prosome, macropain) subunit, beta type, 6; proteasome catalytic subunit 1; Proteasome delta chain; proteasome subunit beta 6; Proteasome subunit beta type-6; proteasome subunit delta; Proteasome subunit Y; PSB6; PSMB6; PSY large multifunctional protease Y; Y
Gene Symbols: PSMB6
Molecular weight: 25,358 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMB6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 P13 LAARGAGPAPAWGPE
0 33 T23-p AWGPEAFtPDWESRE
0 1 T56-p GADSRTTtGSyIANR
0 45 Y59-p SRTTtGSyIANRVTD
0 12 K67-ub IANRVTDkLtPIHDR
0 1 T69-p NRVTDkLtPIHDRIF
0 2 K118-ac HTAASLFkEMCYRYR
1 1 S158-p GGMMVRQsFAIGGSG
0 1 Y177-p YGYVDATyREGMTkE
0 1 K183-ub TyREGMTkEECLQFt
0 1 T190-p kEECLQFtANALALA
0 1 S203-p LAMERDGssGGVIRL
0 1 S204-p AMERDGssGGVIRLA
0 1 S216-p RLAAIAEsGVERQVL
0 2 K230-ub LLGDQIPkFAVATLP
  mouse

 
S12-p LAVRRAGsAPAFGPE
T22-p AFGPEALtPDWENRE
T55 GADSRTTTGSyIANR
Y58-p SRTTTGSyIANRVTD
K66 IANRVTDKLTPIHDH
T68 NRVTDKLTPIHDHIF
K117 HTAASLFKEMCYRYR
S157-p GGMMVRQsFAIGGSG
Y176-p YGYVDATyREGMTKD
K182 TyREGMTKDECLQFT
T189 KDECLQFTANALALA
S202 LAMERDGSSGGVIRL
S203 AMERDGSSGGVIRLA
S215 RLAAIQESGVERQVL
K229 LLGDQIPKFTIATLP
  rat

 
S12 LAVRGAVSAPAFGPE
T22 AFGPEALTPDWENRE
T55 GADSRTTTGSYIANR
Y58 SRTTTGSYIANRVTD
K66 IANRVTDKLTPIHDH
T68 NRVTDKLTPIHDHIF
K117 HTAASLFKEMCYRYR
S157 GGMMVRQSFAIGGSG
Y176 YGYVDATYREGMTKD
K182 TYREGMTKDECLQFT
T189 KDECLQFTANALALA
S202 LAMERDGSSGGVIRL
S203 AMERDGSSGGVIRLA
S215 RLAAIQQSGVERQVL
K229 LLGDQIPKVTISTLP
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