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Lamin B2 (human)

Overview Lamin B2 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: nuclear lamina; intermediate filament; nuclear inner membrane Molecular Function: structural molecule activity Reference #:  Q03252 (UniProtKB) Alt. Names/Synonyms: LAMB2; lamin B2; Lamin-B2; LMN2; LMNB2; MGC2721 Gene Symbols: LMNB2 Molecular weight: 67,689 Da Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Lamin B2 2LLL - A=449-569 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	146		T14-p	GRAGGPAtPLsPtRL
2	83		S17-p	GGPAtPLsPtRLsRL
1	23		T19-p	PAtPLsPtRLsRLQE
0	1		S22-p	PLsPtRLsRLQEKEE
0	2		K57-u	ENDRLLLkIsEkEEV
0	1		S59-p	DRLLLkIsEkEEVTT
0	1		K61-a	LLLkIsEkEEVTTRE
0	2		K61-u	LLLkIsEkEEVTTRE
0	1		K73-u	TREVSGIkALYESEL
0	2		K103-u	RLQIEIGkLRAELDE
0	1		K113-u	AELDEVNksAKKREG
0	1		S114-p	ELDEVNksAKKREGE
0	1		K117	EVNksAKKREGELTV
0	9		K130-u	TVAQGRVkDLESLFH
0	1		S148-p	VELAAALsDkRGLES
0	1		K150-a	LAAALsDkRGLESDV
0	3		K150-u	LAAALsDkRGLESDV
0	5		K166-u	ELRAQLAkAEDGHAV
0	12		K175-a	EDGHAVAkKQLEkET
0	1		K180-u	VAkKQLEkETLMRVD
0	1		S226-p	RRLVEVDsSRQQEYD
0	2		K235-u	RQQEYDFkMAQALEE
0	2		K255-u	DEQVRLYkLELEQTY
0	11		K265-u	LEQTYQAkLDSAkLS
0	7		K270-u	QAkLDSAkLSSDQND
0	5		K278-u	LSSDQNDkAASAARE
0	79		S296-p	EARMRLEsLsyQLSG
0	5		S298-p	RMRLEsLsyQLSGLQ
0	9		Y299-p	MRLEsLsyQLSGLQk
0	44		K306-u	yQLSGLQkQASAAED
0	2		K331-u	GERDKFRkMLDAKEQ
0	1		Y354-p	MQQQLAEyQELLDVK
0	2		N369	LALDMEINAYRkLLE
0	55		K373-u	MEINAYRkLLEGEEE
0	62		K383-u	EGEEERLkLsPsPss
1	27		S385-p	EEERLkLsPsPssRV
1	20		S387-p	ERLkLsPsPssRVTV
0	6		S389-p	LkLsPsPssRVTVSR
0	4		S390-p	kLsPsPssRVTVSRA
0	1		T398-p	RVTVSRAtssssGsL
0	28		S399-p	VTVSRAtssssGsLs
0	9		S400-p	TVSRAtssssGsLsA
2	8		S401-p	VSRAtssssGsLsAt
0	8		S402-p	SRAtssssGsLsAtG
0	1		G403	RAtssssGsLsAtGR
0	7		S404-p	AtssssGsLsAtGRL
1	0		L405	tssssGsLsAtGRLG
0	11		S406-p	ssssGsLsAtGRLGR
0	11		T408-p	ssGsLsAtGRLGRSK
1	0		L411	sLsAtGRLGRSKRKR
1	0		G412	LsAtGRLGRSKRKRL
0	13		R413	sAtGRLGRSKRKRLE
0	34		V421	SKRKRLEVEEPLGSG
0	6		P424	KRLEVEEPLGSGPSV
0	2		L425	RLEVEEPLGSGPSVL
0	25		S427	EVEEPLGSGPSVLGT
0	3		S430	EPLGSGPSVLGTGTG
0	1		-	under review
0	1		S472-p	FVQLKNNsDkDQSLG
0	2		K474-u	QLKNNsDkDQSLGNW
0	1		Y495-p	LEGEEIAykFtPkYI
0	2		K496-u	EGEEIAykFtPkYIL
0	7		T498-p	EEIAykFtPkYILRA
0	1		K500-a	IAykFtPkYILRAGQ
0	3		K500-u	IAykFtPkYILRAGQ
0	1		S521-p	AGAGVAHsPPSTLVW
0	2		G530	PSTLVWKGQSSWGTG
0	1		R555	DGEEVAMRTVKKSSV

	Lamin B2 iso5
T34	GRAGGPATPLSPTRL
S37	GGPATPLSPTRLSRL
T39	PATPLSPTRLSRLQE
S42	PLSPTRLSRLQEKEE
K77	ENDRLLLKISEKEEV
S79	DRLLLKISEKEEVTT
K81	LLLKISEKEEVTTRE
K81	LLLKISEKEEVTTRE
K93	TREVSGIKALYESEL
K123	RLQIEIGKLRAELDE
K133	AELDEVNKSAKKREG
S134	ELDEVNKSAKKREGE
K137	EVNKSAKKREGELTV
K150	TVAQGRVKDLESLFH
S168	VELAAALSDKRGLES
K170	LAAALSDKRGLESDV
K170	LAAALSDKRGLESDV
K186	ELRAQLAKAEDGHAV
K195	EDGHAVAKKQLEKET
K200	VAKKQLEKETLMRVD
S246	RRLVEVDSSRQQEYD
K255	RQQEYDFKMAQALEE
K275	DEQVRLYKLELEQTY
K285	LEQTYQAKLDSAKLS
K290	QAKLDSAKLSSDQND
K298	LSSDQNDKAASAARE
S316	EARMRLESLSYQLSG
S318	RMRLESLSYQLSGLQ
Y319	MRLESLSYQLSGLQK
K326	YQLSGLQKQASAAED
K351	GERDKFRKMLDAKEQ
Y374	MQQQLAEYQELLDVK
N389	LALDMEINAYRKLLE
K393	MEINAYRKLLEGEEE
K403	EGEEERLKLSPSPSS
S405	EEERLKLSPSPSSRV
S407	ERLKLSPSPSSRVTV
S409	LKLSPSPSSRVTVSR
S410	KLSPSPSSRVTVSRA
T418	RVTVSRATSSSSGSL
S419	VTVSRATSSSSGSLS
S420	TVSRATSSSSGSLSA
S421	VSRATSSSSGSLSAT
S422	SRATSSSSGSLSATG
G423	RATSSSSGSLSATGR
S424	ATSSSSGSLSATGRL
L425	TSSSSGSLSATGRLG
S426	SSSSGSLSATGRLGR
T428	SSGSLSATGRLGRSK
L431	SLSATGRLGRSKRKR
G432	LSATGRLGRSKRKRL
R433	SATGRLGRSKRKRLE
V441	SKRKRLEVEEPLGSG
P444	KRLEVEEPLGSGPSV
L445	RLEVEEPLGSGPSVL
S447	EVEEPLGSGPSVLGT
S450	EPLGSGPSVLGTGTG
-	under review
S492	FVQLKNNSDKDQSLG
K494	QLKNNSDKDQSLGNW
Y515	LEGEEIAYKFTPKYI
K516	EGEEIAYKFTPKYIL
T518	EEIAYKFTPKYILRA
K520	IAYKFTPKYILRAGQ
K520	IAYKFTPKYILRAGQ
S541	AGAGVAHSPPSTLVW
G550	PSTLVWKGQSSWGTG
R575	DGEEVAMRTVKKSSV

	mouse
T12-p	PPHAGPAtPLsPTRL
S15-p	AGPAtPLsPTRLSRL
T17	PAtPLsPTRLSRLQE
S20	PLsPTRLSRLQEKEE
R55	ENDRLLLRISEkEEV
S57	DRLLLRISEkEEVTT
K59	LLLRISEKEEVTTRE
K59-u	LLLRISEkEEVTTRE
K71	TREVSGIKTLYESEL
K101-u	RLQIEIGkVQAELEE
K111	AELEEARKSAKkREG
S112	ELEEARKSAKkREGE
K115-u	EARKSAKkREGELTV
K128-u	TVAQGRVkDLESLFH
S146	AELATALSDkQGLET
K148	LATALSDKQGLETEV
K148-u	LATALSDkQGLETEV
K164-u	ELRAQLAkAEDGHAV
K173	EDGHAVAKKQLEKET
K178	VAKKQLEKETLMRVD
S224	RRLVEVDSSRQQEYD
K233-u	RQQEYDFkMAQALED
R253	DEQVRLYRVELEQTY
K263-u	LEQTYQAkLDNAkLL
K268-u	QAkLDNAkLLSDQND
K276-u	LLSDQNDkAAHAARE
S294-p	EARMRVEsLsYQLLG
S296-p	RMRVEsLsYQLLGLQ
Y297	MRVEsLsYQLLGLQK
K304	YQLLGLQKQASAAEN
K329-u	GERDKFRkMLDAKEQ
Y352	MQQQLAEYQELLDIK
S367-p	LALDMEIsAYRkLLE
K371-u	MEIsAYRkLLEGEEE
K381-u	EGEEERLkLsPsPss
S383-p	EEERLkLsPsPssRI
S385-p	ERLkLsPsPssRITI
S387-p	LkLsPsPssRITISR
S388-p	kLsPsPssRITISRA
T396	RITISRATSSSssSs
S397	ITISRATSSSssSsG
S398	TISRATSSSssSsGV
S399	ISRATSSSssSsGVG
S400-p	SRATSSSssSsGVGM
S401-p	RATSSSssSsGVGMS
S402	ATSSSssSsGVGMSV
-	gap
S403-p	TSSSssSsGVGMSVG
S408	sSsGVGMSVGQGrGK
Q411	GVGMSVGQGrGKRRR
G412	VGMSVGQGrGKRRRL
R413-m1	GMSVGQGrGKRRRLE
T421-p	GKRRRLEtEDtsGsP
T424-p	RRLEtEDtsGsPsRA
S425-p	RLEtEDtsGsPsRAs
S427-p	EtEDtsGsPsRAsRV
S429-p	EDtsGsPsRAsRVSS
S432-p	sGsPsRAsRVSSGSR
S468	FVRLKNSSDkDQSLG
K470-u	RLKNSSDkDQSLGNW
Y491-p	LEGEDIAyKFtPkYV
K492	EGEDIAyKFtPkYVL
T494-p	EDIAyKFtPkYVLRA
K496	IAyKFtPKYVLRAGQ
K496-u	IAyKFtPkYVLRAGQ
S517	AGAGATHSPPSTLVW
S526-p	PSTLVWKsQTNWGPG
K551-u	DGEEVAVkAAKHSSV

	rat
T30	PPRAGSATPLSPTRL
S33	AGSATPLSPTRLSRL
T35	SATPLSPTRLSRLQE
S38	PLSPTRLSRLQEKEE
R73	ENDKLLLRISEKEEV
S75	DKLLLRISEKEEVTT
K77	LLLRISEKEEVTTRE
K77	LLLRISEKEEVTTRE
K89	TREVSGIKTLYESEL
K119	RLQIEIGKVQAELEE
K129	AELEEAKKSAKKREG
S130	ELEEAKKSAKKREGE
K133	EAKKSAKKREGELTV
K146	TVARGRVKDLESLFH
G164	AELAAALGDKHVLET
K166	LAAALGDKHVLETEV
K166	LAAALGDKHVLETEV
K182	ELRAQLAKAEDGHAV
K191	EDGHAVAKKQLEKET
K196	VAKKQLEKETLMRVD
S242	RHLVEVDSSRQQEYD
K251	RQQEYDFKIAQALEE
R271	DEQVRLYRLELEQTY
K281	LEQTYQAKLDNTKLI
K286	QAKLDNTKLISDQND
K294	LISDQNDKAARAARE
S312	EARMRVESLSYQLSG
S314	RMRVESLSYQLSGLQ
Y315	MRVESLSYQLSGLQK
K322	YQLSGLQKQASAAED
N347	GERDKFRNMLDAKEQ
Y370	MQQQLAEYQELLDIK
C385	LALDMEICSYRKLLE
K389	MEICSYRKLLEGEEE
K399	EGEEERLKLSPSPSS
S401	EEERLKLSPSPSSRV
S403	ERLKLSPSPSSRVTI
S405	LKLSPSPSSRVTISL
S406	KLSPSPSSRVTISLA
T414	RVTISLATSSSSSSS
S415	VTISLATSSSSSSSS
S416	TISLATSSSSSSSSS
S417	ISLATSSSSSSSSSG
S418	SLATSSSSSSSSSGV
S419	LATSSSSSSSSSGVG
S420	ATSSSSSSSSSGVGM
S421	TSSSSSSSSSGVGMS
S422	SSSSSSSSSGVGMSL
S428	SSSGVGMSLGRGRSK
R431	GVGMSLGRGRSKRQR
G432	VGMSLGRGRSKRQRL
R433	GMSLGRGRSKRQRLE
T441	SKRQRLETEDTPGSP
T444	QRLETEDTPGSPSSA
P445	RLETEDTPGSPSSAS
S447	ETEDTPGSPSSASSV
S449	EDTPGSPSSASSVSS
S452	PGSPSSASSVSSGSR
S488	FVRLKNSSDKDQSLG
K490	RLKNSSDKDQSLGNW
Y511	LEGEDIAYKFTPKYV
K512	EGEDIAYKFTPKYVL
T514	EDIAYKFTPKYVLRA
K516	IAYKFTPKYVLRAGQ
K516	IAYKFTPKYVLRAGQ
S537	AGAGATHSPPSTLVW
N546	PSTLVWKNQSSWGSG
Q571	DGEEVAVQAAKPPSV

	chicken
T13	IRGTPGGTPLSPTRI
S16	TPGGTPLSPTRISRL
T18	GGTPLSPTRISRLQE
S21	PLSPTRISRLQEKEE
K56	ENDRLLVKISEKEEV
S58	DRLLVKISEKEEVTT
K60	LLVKISEKEEVTTRE
K60	LLVKISEKEEVTTRE
K72	TREVSGIKNLYESEL
K102	RLQIEIGKLRAELEE
K112	AELEEFNKSYKKKDA
S113	ELEEFNKSYKKKDAD
K116	EFNKSYKKKDADLSV
K129	SVAQGRIKDLEVLFH
N147	AELNTVLNEKRSLEA
K149	LNTVLNEKRSLEAEV
K149	LNTVLNEKRSLEAEV
K165	DLRAQLAKAEDGHAV
K174	EDGHAVAKKQLEKET
K179	VAKKQLEKETLMRVD
T225	HRLVEVDTSRQQEYE
K234	RQQEYENKMAQALED
K254	DEQVKLYKMELEQTY
K264	LEQTYQAKLENAILA
I269	QAKLENAILASDQND
K277	LASDQNDKAAGAARE
S295	EARMRIESLSHQLSG
S297	RMRIESLSHQLSGLQ
H298	MRIESLSHQLSGLQK
K305	HQLSGLQKQASATED
K330	GERDKFRKMLDAKER
Y353	MQLQLTEYQELLDVK
S368	LALDMEISAYRKLLE
K372	MEISAYRKLLEGEEE
K382	EGEEERLKLSPSPSS
S384	EEERLKLSPSPSSRV
S386	ERLKLSPSPSSRVTV
S388	LKLSPSPSSRVTVSR
S389	KLSPSPSSRVTVSRA
T397	RVTVSRATSSsSSSs
S398	VTVSRATSSsSSSsT
S399	TVSRATSSsSSSsTS
S400-p	VSRATSSsSSSsTSL
S401	SRATSSsSSSsTSLV
S402	RATSSsSSSsTSLVR
S403	ATSSsSSSsTSLVRs
S404-p	TSSsSSSsTSLVRss
T405	SSsSSSsTSLVRssR
L407	sSSSsTSLVRssRGK
S410-p	SsTSLVRssRGKRRR
S411-p	sTSLVRssRGKRRRI
R412	TSLVRssRGKRRRIE
A420	GKRRRIEAEELSGSG
L423	RRIEAEELSGSGTSG
S424	RIEAEELSGSGTSGI
S426	EAEELSGSGTSGIGT
S429	ELSGSGTSGIGTGSI
-	under review
S475	YVQLKNNSEKDQSLG
K477	QLKNNSEKDQSLGNW
Y498	GDGEEIAYKFTPKYV
K499	DGEEIAYKFTPKYVL
T501	EEIAYKFTPKYVLRA
K503	IAYKFTPKYVLRAGQ
K503	IAYKFTPKYVLRAGQ
S524	ADAGVSHSPPSVLVW
N533	PSVLVWKNQGSWGTG
R558	DGEEVAVRTVTKSVV

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