Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Lamin B2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Lamin B2 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: lamin filament; nuclear inner membrane
Molecular Function: structural molecule activity
Reference #:  Q03252 (UniProtKB)
Alt. Names/Synonyms: LAMB2; lamin B2; Lamin-B2; LMN2; LMNB2; MGC2721
Gene Symbols: LMNB2
Molecular weight: 67,689 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Lamin B2

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T3-p _____MAtPLPGRAG
0 1 - gap
1 176 T14-p GRAGGPAtPLsPtRL
2 92 S17-p GGPAtPLsPtRLsRL
1 27 T19-p PAtPLsPtRLsRLQE
0 2 S22-p PLsPtRLsRLQEkEE
0 2 K27-ac RLsRLQEkEELRELN
0 2 K57-ub ENDRLLLkIsEkEEV
0 1 S59-p DRLLLkIsEkEEVTT
0 2 K61-ac LLLkIsEkEEVTTRE
0 2 K61-ub LLLkIsEkEEVTTRE
0 1 K73-ub TREVSGIkALYESEL
0 2 K103-ub RLQIEIGkLRAELDE
0 1 K113-ub AELDEVNksAKKREG
0 2 S114-p ELDEVNksAKKREGE
0 1 K117 EVNksAKKREGELTV
0 9 K130-ub TVAQGRVkDLEsLFH
0 1 S134-p GRVkDLEsLFHRSEV
0 1 A145 RSEVELAAALsDkRG
0 2 S148-p VELAAALsDkRGLEs
0 1 K150-ac LAAALsDkRGLEsDV
0 3 K150-ub LAAALsDkRGLEsDV
0 1 S155-p sDkRGLEsDVAELRA
0 5 K166-ub ELRAQLAkAEDGHAV
0 12 K175-ac EDGHAVAkKQLEkET
0 1 K180 VAkKQLEKETLMRVD
0 1 K180-ub VAkKQLEkETLMRVD
0 1 S226-p RRLVEVDsSRQQEYD
0 2 K235-ub RQQEYDFkMAQALEE
0 2 K255-ub DEQVRLYkLELEQTY
0 1 K265 LEQTYQAKLDSAkLS
0 11 K265-ub LEQTYQAkLDSAkLS
0 1 K270 QAkLDSAKLSSDQND
0 7 K270-ub QAkLDSAkLSSDQND
0 5 K278-ub LSSDQNDkAAsAARE
0 1 S281-p DQNDkAAsAAREELK
0 83 S296-p EARMRLEsLsyQLSG
0 5 S298-p RMRLEsLsyQLSGLQ
0 10 Y299-p MRLEsLsyQLSGLQk
0 1 K306 yQLSGLQKQASAAED
0 44 K306-ub yQLSGLQkQASAAED
0 2 K331-ub GERDKFRkMLDAKEQ
0 1 K336 FRkMLDAKEQEMTEM
0 1 Y354-p MQQQLAEyQELLDVK
0 2 N369 LALDMEINAYRkLLE
0 2 K373-ac MEINAYRkLLEGEEE
0 55 K373-ub MEINAYRkLLEGEEE
0 62 K383-ub EGEEERLkLsPsPss
1 42 S385-p EEERLkLsPsPssRV
1 34 S387-p ERLkLsPsPssRVTV
0 9 S389-p LkLsPsPssRVTVSR
0 5 S390-p kLsPsPssRVTVSRA
0 1 T398-p RVTVSRAtssssGsL
0 33 S399-p VTVSRAtssssGsLs
0 13 S400-p TVSRAtssssGsLsA
2 11 S401-p VSRAtssssGsLsAt
0 12 S402-p SRAtssssGsLsAtG
0 1 G403 RAtssssGsLsAtGR
0 12 S404-p AtssssGsLsAtGRL
1 0 L405 tssssGsLsAtGRLG
0 14 S406-p ssssGsLsAtGRLGR
0 13 T408-p ssGsLsAtGRLGRSK
1 0 L411 sLsAtGRLGRSKRKR
1 0 G412 LsAtGRLGRSKRKRL
0 14 R413 sAtGRLGRSKRKRLE
0 35 V421 SKRKRLEVEEPLGSG
0 6 P424 KRLEVEEPLGSGPSV
0 3 L425 RLEVEEPLGSGPSVL
0 27 S427 EVEEPLGSGPSVLGT
0 4 S430 EPLGSGPSVLGTGTG
0 1 T434 SGPSVLGTGTGGSGG
0 1 S472-p FVQLKNNsDkDQsLG
0 2 K474-ub QLKNNsDkDQsLGNW
0 2 S477-p NNsDkDQsLGNWRIK
0 1 Y495-p LEGEEIAykFtPkYI
0 2 K496-ub EGEEIAykFtPkYIL
0 8 T498-p EEIAykFtPkYILRA
0 1 K500-ac IAykFtPkYILRAGQ
0 3 K500-ub IAykFtPkYILRAGQ
0 2 S521-p AGAGVAHsPPSTLVW
0 2 G530 PSTLVWKGQsSWGtG
0 1 S532-p TLVWKGQsSWGtGES
0 1 T536-p KGQsSWGtGESFRTV
0 1 R555 DGEEVAMRTVKKSSV
  Lamin B2 iso5  
T23 RAAATMATPLPGRAG
- gap
T34 GRAGGPATPLSPTRL
S37 GGPATPLSPTRLSRL
T39 PATPLSPTRLSRLQE
S42 PLSPTRLSRLQEKEE
K47 RLSRLQEKEELRELN
K77 ENDRLLLKISEKEEV
S79 DRLLLKISEKEEVTT
K81 LLLKISEKEEVTTRE
K81 LLLKISEKEEVTTRE
K93 TREVSGIKALYESEL
K123 RLQIEIGKLRAELDE
K133 AELDEVNKSAKKREG
S134 ELDEVNKSAKKREGE
K137 EVNKSAKKREGELTV
K150 TVAQGRVKDLESLFH
S154 GRVKDLESLFHRSEV
A165 RSEVELAAALSDKRG
S168 VELAAALSDKRGLES
K170 LAAALSDKRGLESDV
K170 LAAALSDKRGLESDV
S175 SDKRGLESDVAELRA
K186 ELRAQLAKAEDGHAV
K195 EDGHAVAKKQLEKET
K200 VAKKQLEKETLMRVD
K200 VAKKQLEKETLMRVD
S246 RRLVEVDSSRQQEYD
K255 RQQEYDFKMAQALEE
K275 DEQVRLYKLELEQTY
K285 LEQTYQAKLDSAKLS
K285 LEQTYQAKLDSAKLS
K290 QAKLDSAKLSSDQND
K290 QAKLDSAKLSSDQND
K298 LSSDQNDKAASAARE
S301 DQNDKAASAAREELK
S316 EARMRLESLSYQLSG
S318 RMRLESLSYQLSGLQ
Y319 MRLESLSYQLSGLQK
K326 YQLSGLQKQASAAED
K326 YQLSGLQKQASAAED
K351 GERDKFRKMLDAKEQ
K356 FRKMLDAKEQEMTEM
Y374 MQQQLAEYQELLDVK
N389 LALDMEINAYRKLLE
K393 MEINAYRKLLEGEEE
K393 MEINAYRKLLEGEEE
K403 EGEEERLKLSPSPSS
S405 EEERLKLSPSPSSRV
S407 ERLKLSPSPSSRVTV
S409 LKLSPSPSSRVTVSR
S410 KLSPSPSSRVTVSRA
T418 RVTVSRATSSSSGSL
S419 VTVSRATSSSSGSLS
S420 TVSRATSSSSGSLSA
S421 VSRATSSSSGSLSAT
S422 SRATSSSSGSLSATG
G423 RATSSSSGSLSATGR
S424 ATSSSSGSLSATGRL
L425 TSSSSGSLSATGRLG
S426 SSSSGSLSATGRLGR
T428 SSGSLSATGRLGRSK
L431 SLSATGRLGRSKRKR
G432 LSATGRLGRSKRKRL
R433 SATGRLGRSKRKRLE
V441 SKRKRLEVEEPLGSG
P444 KRLEVEEPLGSGPSV
L445 RLEVEEPLGSGPSVL
S447 EVEEPLGSGPSVLGT
S450 EPLGSGPSVLGTGTG
T454 SGPSVLGTGTGGSGG
S492 FVQLKNNSDKDQSLG
K494 QLKNNSDKDQSLGNW
S497 NNSDKDQSLGNWRIK
Y515 LEGEEIAYKFTPKYI
K516 EGEEIAYKFTPKYIL
T518 EEIAYKFTPKYILRA
K520 IAYKFTPKYILRAGQ
K520 IAYKFTPKYILRAGQ
S541 AGAGVAHSPPSTLVW
G550 PSTLVWKGQSSWGTG
S552 TLVWKGQSSWGTGES
T556 KGQSSWGTGESFRTV
R575 DGEEVAMRTVKKSSV
  mouse

 
S3 _____MASLPPHAGP
- gap
T12-p PPHAGPAtPLsPTRL
S15-p AGPAtPLsPTRLSRL
T17 PAtPLsPTRLSRLQE
S20 PLsPTRLSRLQEkEE
K25-ac RLSRLQEkEELRELN
R55 ENDRLLLRISEkEEV
S57 DRLLLRISEkEEVTT
K59-ac LLLRISEkEEVTTRE
K59-ub LLLRISEkEEVTTRE
K71 TREVSGIKTLYESEL
K101-ub RLQIEIGkVQAELEE
K111 AELEEARKSAKkREG
S112 ELEEARKSAKkREGE
K115-ub EARKSAKkREGELTV
K128-ub TVAQGRVkDLEsLFH
S132-p GRVkDLEsLFHRSEA
T143-p RSEAELAtALsDkQG
S146-p AELAtALsDkQGLET
K148 LAtALsDKQGLETEV
K148-ub LAtALsDkQGLETEV
T153 sDkQGLETEVAELRA
K164-ub ELRAQLAkAEDGHAV
K173 EDGHAVAKKQLEkET
K178-ac VAKKQLEkETLMRVD
K178 VAKKQLEKETLMRVD
S224 RRLVEVDSSRQQEYD
K233-ub RQQEYDFkMAQALED
R253 DEQVRLYRVELEQTY
K263-ac LEQTYQAkLDNAkLL
K263-ub LEQTYQAkLDNAkLL
K268-ac QAkLDNAkLLSDQND
K268-ub QAkLDNAkLLSDQND
K276-ub LLSDQNDkAAHAARE
H279 DQNDkAAHAAREELK
S294-p EARMRVEsLsYQLLG
S296-p RMRVEsLsYQLLGLQ
Y297 MRVEsLsYQLLGLQk
K304-ac YQLLGLQkQASAAEN
K304 YQLLGLQKQASAAEN
K329-ub GERDKFRkMLDAkEQ
K334-ac FRkMLDAkEQEMTEV
Y352 MQQQLAEYQELLDIK
S367-p LALDMEIsAYRkLLE
K371-ac MEIsAYRkLLEGEEE
K371-ub MEIsAYRkLLEGEEE
K381-ub EGEEERLkLsPsPss
S383-p EEERLkLsPsPssRI
S385-p ERLkLsPsPssRITI
S387-p LkLsPsPssRITISR
S388-p kLsPsPssRITISRA
T396 RITISRATSSSssss
S397 ITISRATSSSssssG
S398 TISRATSSSssssGV
S399 ISRATSSSssssGVG
S400-p SRATSSSssssGVGM
S401-p RATSSSssssGVGMS
S402-p ATSSSssssGVGMSV
- gap
S403-p TSSSssssGVGMSVG
S408 sssGVGMSVGQGrGK
Q411 GVGMSVGQGrGKRRR
G412 VGMSVGQGrGKRRRL
R413-m1 GMSVGQGrGKRRRLE
T421-p GKRRRLEtEDtsGsP
T424-p RRLEtEDtsGsPsRA
S425-p RLEtEDtsGsPsRAs
S427-p EtEDtsGsPsRAsRV
S429-p EDtsGsPsRAsRVSS
S432-p sGsPsRAsRVSSGSR
S468 FVRLKNSSDkDQSLG
K470-ub RLKNSSDkDQSLGNW
S473 NSSDkDQSLGNWRIK
Y491-p LEGEDIAyKFtPkYV
K492 EGEDIAyKFtPkYVL
T494-p EDIAyKFtPkYVLRA
K496 IAyKFtPKYVLRAGQ
K496-ub IAyKFtPkYVLRAGQ
S517 AGAGATHSPPSTLVW
S526-p PSTLVWKsQTNWGPG
T528 TLVWKsQTNWGPGES
P532 KsQTNWGPGESFRTA
K551-ub DGEEVAVkAAKHSSV
  rat

 
S21 AAATAMASLPPRAGs
S28-p SLPPRAGsATPLSPt
T30 PPRAGsATPLSPtRL
S33 AGsATPLSPtRLSRL
T35-p sATPLSPtRLSRLQE
S38 PLSPtRLSRLQEkEE
K43-ac RLSRLQEkEELRELN
R73 ENDKLLLRISEkEEV
S75 DKLLLRISEkEEVTT
K77-ac LLLRISEkEEVTTRE
K77 LLLRISEKEEVTTRE
K89 TREVSGIKTLYESEL
K119 RLQIEIGKVQAELEE
K129 AELEEAKKSAKKREG
S130 ELEEAKKSAKKREGE
K133 EAKKSAKKREGELTV
K146 TVARGRVKDLESLFH
S150 GRVKDLESLFHRSEA
A161 RSEAELAAALGDkHV
G164 AELAAALGDkHVLET
K166-ac LAAALGDkHVLETEV
K166 LAAALGDKHVLETEV
T171 GDkHVLETEVAELRA
K182 ELRAQLAKAEDGHAV
K191 EDGHAVAKKQLEKET
K196 VAKKQLEKETLMRVD
K196 VAKKQLEKETLMRVD
S242 RHLVEVDSSRQQEYD
K251 RQQEYDFKIAQALEE
R271 DEQVRLYRLELEQTY
K281 LEQTYQAKLDNTkLI
K281 LEQTYQAKLDNTkLI
K286-ac QAKLDNTkLISDQND
K286 QAKLDNTKLISDQND
K294 LISDQNDKAARAARE
R297 DQNDKAARAAREELK
S312 EARMRVESLSYQLSG
S314 RMRVESLSYQLSGLQ
Y315 MRVESLSYQLSGLQK
K322 YQLSGLQKQASAAED
K322 YQLSGLQKQASAAED
N347 GERDKFRNMLDAKEQ
K352 FRNMLDAKEQEMAEV
Y370 MQQQLAEYQELLDIK
C385 LALDMEICSYRkLLE
K389-ac MEICSYRkLLEGEEE
K389 MEICSYRKLLEGEEE
K399 EGEEERLKLsPsPSS
S401-p EEERLKLsPsPSSRV
S403-p ERLKLsPsPSSRVTI
S405 LKLsPsPSSRVTISL
S406 KLsPsPSSRVTISLA
T414 RVTISLATSSSSSSS
S415 VTISLATSSSSSSSS
S416 TISLATSSSSSSSSS
S417 ISLATSSSSSSSSSG
S418 SLATSSSSSSSSSGV
S419 LATSSSSSSSSSGVG
S420 ATSSSSSSSSSGVGM
S421 TSSSSSSSSSGVGMS
S422 SSSSSSSSSGVGMSL
S428 SSSGVGMSLGRGRSK
R431 GVGMSLGRGRSKRQR
G432 VGMSLGRGRSKRQRL
R433 GMSLGRGRSKRQRLE
T441 SKRQRLETEDTPGsP
T444 QRLETEDTPGsPSSA
P445 RLETEDTPGsPSSAS
S447-p ETEDTPGsPSSASSV
S449 EDTPGsPSSASSVSS
S452 PGsPSSASSVSSGSR
S488 FVRLKNSSDKDQSLG
K490 RLKNSSDKDQSLGNW
S493 NSSDKDQSLGNWRIK
Y511 LEGEDIAYKFTPkYV
K512 EGEDIAYKFTPkYVL
T514 EDIAYKFTPkYVLRA
K516-ac IAYKFTPkYVLRAGQ
K516 IAYKFTPKYVLRAGQ
S537 AGAGATHSPPSTLVW
N546 PSTLVWKNQSSWGSG
S548 TLVWKNQSSWGSGEN
S552 KNQSSWGSGENFRTV
Q571 DGEEVAVQAAKPPSV
  chicken

 
S2 ______MSGTPIRGT
- gap
T13 IRGTPGGTPLSPTRI
S16 TPGGTPLSPTRISRL
T18 GGTPLSPTRISRLQE
S21 PLSPTRISRLQEKEE
K26 RISRLQEKEELRQLN
K56 ENDRLLVKISEKEEV
S58 DRLLVKISEKEEVTT
K60 LLVKISEKEEVTTRE
K60 LLVKISEKEEVTTRE
K72 TREVSGIKNLYESEL
K102 RLQIEIGKLRAELEE
K112 AELEEFNKSYKKKDA
S113 ELEEFNKSYKKKDAD
K116 EFNKSYKKKDADLSV
K129 SVAQGRIKDLEVLFH
V133 GRIKDLEVLFHRSEA
T144 RSEAELNTVLNEKRS
N147 AELNTVLNEKRSLEA
K149 LNTVLNEKRSLEAEV
K149 LNTVLNEKRSLEAEV
A154 NEKRSLEAEVADLRA
K165 DLRAQLAKAEDGHAV
K174 EDGHAVAKKQLEKET
K179 VAKKQLEKETLMRVD
K179 VAKKQLEKETLMRVD
T225 HRLVEVDTSRQQEYE
K234 RQQEYENKMAQALED
K254 DEQVKLYKMELEQTY
K264 LEQTYQAKLENAILA
K264 LEQTYQAKLENAILA
I269 QAKLENAILASDQND
I269 QAKLENAILASDQND
K277 LASDQNDKAAGAARE
G280 DQNDKAAGAAREELK
S295 EARMRIESLSHQLSG
S297 RMRIESLSHQLSGLQ
H298 MRIESLSHQLSGLQK
K305 HQLSGLQKQASATED
K305 HQLSGLQKQASATED
K330 GERDKFRKMLDAKER
K335 FRKMLDAKEREMTEM
Y353 MQLQLTEYQELLDVK
S368 LALDMEISAYRKLLE
K372 MEISAYRKLLEGEEE
K372 MEISAYRKLLEGEEE
K382 EGEEERLKLSPSPSS
S384 EEERLKLSPSPSSRV
S386 ERLKLSPSPSSRVTV
S388 LKLSPSPSSRVTVSR
S389 KLSPSPSSRVTVSRA
T397 RVTVSRATSSsSSSs
S398 VTVSRATSSsSSSsT
S399 TVSRATSSsSSSsTS
S400-p VSRATSSsSSSsTSL
S401 SRATSSsSSSsTSLV
S402 RATSSsSSSsTSLVR
S403 ATSSsSSSsTSLVRs
S404-p TSSsSSSsTSLVRss
T405 SSsSSSsTSLVRssR
L407 sSSSsTSLVRssRGK
S410-p SsTSLVRssRGKRRR
S411-p sTSLVRssRGKRRRI
R412 TSLVRssRGKRRRIE
A420 GKRRRIEAEELSGSG
L423 RRIEAEELSGSGTSG
S424 RIEAEELSGSGTSGI
S426 EAEELSGSGTSGIGT
S429 ELSGSGTSGIGTGSI
S435 TSGIGTGSISGSSSS
S475 YVQLKNNSEKDQSLG
K477 QLKNNSEKDQSLGNW
S480 NNSEKDQSLGNWRLK
Y498 GDGEEIAYKFTPKYV
K499 DGEEIAYKFTPKYVL
T501 EEIAYKFTPKYVLRA
K503 IAYKFTPKYVLRAGQ
K503 IAYKFTPKYVLRAGQ
S524 ADAGVSHSPPSVLVW
N533 PSVLVWKNQGSWGTG
G535 VLVWKNQGSWGTGGN
T539 KNQGSWGTGGNIRTY
R558 DGEEVAVRTVTKSVV
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.