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Protein Page:
IkB-epsilon (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IkB-epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein; DNA binding protein
Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding
Biological Process: cytoplasmic sequestering of transcription factor; D-serine transport
Reference #:  O00221 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Gene Symbols: NFKBIE
Molecular weight: 52,864 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Select Structure to View Below

IkB-epsilon

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S54-p RVRRPCWsGGAGRGG
0 1 S153-p GPDEAEEsQyDsGIE
0 174 Y155-p DEAEEsQyDsGIEsL
1 6 S157-p AEEsQyDsGIEsLRs
2 1 S161-p QyDsGIEsLRsLRSL
0 1 S164-p sGIEsLRsLRSLPES
0 1 S177-p ESTSAPAsGPSDGsP
0 2 S183-p AsGPSDGsPQPCTHP
0 1 K316-ub AVRALVLkGASRALQ
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
  IkB-epsilon iso3  
- gap
S76 GPDEAEESQyDSGIE
Y78-p DEAEESQyDSGIESL
S80 AEESQyDSGIESLRS
S84 QyDSGIESLRSLRSL
S87 SGIESLRSLRSLPES
S100 ESTSAPASGPSDGSP
S106 ASGPSDGSPQPCTHP
K239 AVRALVLKGASRALQ
  mouse

 
- gap
S14 GPDEADDSQCDsGIE
C16 DEADDSQCDsGIEsL
S18-p ADDSQCDsGIEsLRS
S22-p QCDsGIEsLRSLRSL
S25 sGIEsLRSLRSLPEP
S38 EPTAAPGSGSSQSGC
C45 SGSSQSGCPQPWRHA
K180 VVRALVLKGASRILQ
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
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