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IkB-epsilon (human)

Overview IkB-epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Inhibitor protein Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; cytosol Biological Process: cytoplasmic sequestering of transcription factor; D-serine transport Reference #:  O00221 (UniProtKB) Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon Gene Symbols: NFKBIE Molecular weight: 52,864 Da Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling

Select Structure to View Below IkB-epsilon

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S54-p	RVRRPCWsGGAGRGG
0	1		S153-p	GPDEAEEsQyDsGIE
0	217		Y155-p	DEAEEsQyDsGIEsL
1	4		S157-p	AEEsQyDsGIEsLRs
2	1		S161-p	QyDsGIEsLRsLRSL
0	1		S164-p	sGIEsLRsLRSLPES
0	1		K316-u	AVRALVLkGASRALQ

	IkB-epsilon iso3
-	gap
S76	GPDEAEESQyDSGIE
Y78-p	DEAEESQyDSGIESL
S80	AEESQyDSGIESLRS
S84	QyDSGIESLRSLRSL
S87	SGIESLRSLRSLPES
K239	AVRALVLKGASRALQ

	mouse
-	gap
S14	GPDEADDSQCDsGIE
C16	DEADDSQCDsGIEsL
S18-p	ADDSQCDsGIEsLRS
S22-p	QCDsGIEsLRSLRSL
S25	sGIEsLRSLRSLPEP
K180	VVRALVLKGASRILQ

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