Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
IkB-epsilon (human)

Overview
IkB-epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Inhibitor protein
Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding
Biological Process: cytoplasmic sequestering of transcription factor; D-serine transport
Reference #:  O00221 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Gene Symbols: NFKBIE
Molecular weight: 52,864 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Select Structure to View Below

IkB-epsilon

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 217 Y155-p DEAEESQyDsGIEsL
1 5 S157-p AEESQyDsGIEsLRS
2 1 S161-p QyDsGIEsLRSLRSL
0 1 S183-p ASGPSDGsPQPCTHP
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
  IkB-epsilon iso3  
Y78-p DEAEESQyDSGIESL
S80 AEESQyDSGIESLRS
S84 QyDSGIESLRSLRSL
S106 ASGPSDGSPQPCTHP
  mouse

 
C16 DEADDSQCDsGIEsL
S18-p ADDSQCDsGIEsLRS
S22-p QCDsGIEsLRSLRSL
C45 SGSSQSGCPQPWRHA
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
4924 : Phospho-IkappaB-epsilon (Ser18/22) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.