DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Nuclear receptor co-regulator
Molecular Function: C-X-C chemokine binding; lipopolysaccharide binding; lyase activity; cytokine activity; bubble DNA binding; transcription factor binding; RAGE receptor binding; protein binding; four-way junction DNA binding; double-stranded DNA binding; damaged DNA binding; chromatin binding; DNA bending activity; transcription factor activity; single-stranded DNA binding; chemoattractant activity
Biological Process: positive regulation of mismatch repair; DNA topological change; positive regulation of apoptosis; apoptosis; programmed cell death; positive regulation of JNK cascade; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; DNA geometric change; DNA recombination; elevation of cytosolic calcium ion concentration; regulation of tolerance induction; positive chemotaxis; positive regulation of MAPKKK cascade; DNA ligation during DNA repair; dendritic cell chemotaxis; DNA fragmentation during apoptosis; inflammatory response; neurite development; positive regulation of DNA binding; cell structure disassembly during apoptosis; negative regulation of transcriptional preinitiation complex assembly; V(D)J recombination; regulation of restriction endodeoxyribonuclease activity; negative regulation of blood vessel endothelial cell migration; positive regulation of interleukin-1 secretion; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; innate immune response; regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; activation of innate immune response
Alt. Names/Synonyms: Amphoterin; DKFZp686A04236; high mobility group box 1; High mobility group protein 1; High mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG-1; HMG1; HMG3; HMGB1; SBP-1; Sulfoglucuronyl carbohydrate binding protein
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.