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HMGB1
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; DNA repair |
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Cellular Component: nucleoplasm; extracellular space; neuron projection; cell surface; transcriptional repressor complex; cytoplasm; extracellular region; condensed chromosome; nucleus
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Molecular Function: protein binding; RAGE receptor binding; double-stranded DNA binding; damaged DNA binding; cytokine activity; transcription factor binding; protein kinase activator activity; transcription factor activity; DNA bending activity; single-stranded DNA binding; chemoattractant activity
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Biological Process: DNA topological change; positive regulation of myeloid cell differentiation; positive regulation of apoptosis; apoptosis; response to glucocorticoid stimulus; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of glycogen catabolic process; DNA recombination; positive chemotaxis; DNA ligation during DNA repair; dendritic cell chemotaxis; DNA fragmentation during apoptosis; neurite development; cell structure disassembly during apoptosis; positive regulation of DNA binding; negative regulation of transcriptional preinitiation complex assembly; V(D)J recombination; base-excision repair, DNA ligation; regulation of transcription from RNA polymerase II promoter; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; eye development; innate immune response; positive regulation of transcription from RNA polymerase II promoter; lung development
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Reference #:
P09429 (UniProtKB)
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| Alt. Names/Synonyms: Amphoterin; DKFZp686A04236; high mobility group box 1; High mobility group protein 1; High mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG-1; HMG1; HMG3; HMGB1; SBP-1; Sulfoglucuronyl carbohydrate binding protein |
| Gene Symbols: HMGB1 |
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Molecular weight: 24,894 Da
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Basal Isoelectric point: 5.62
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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