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GRP94 (human)

Overview GRP94 Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP. Interacts with TLR4 and TLR9, but not with TLR3. Belongs to the heat shock protein 90 family. Note: This description may include information from UniProtKB. Protein type: Secreted; Apoptosis; Secreted, signal peptide Cellular Component: endoplasmic reticulum membrane; perinuclear region of cytoplasm; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; midbody; cytosol Molecular Function: protein binding; low-density lipoprotein receptor binding; RNA binding; unfolded protein binding; virion binding; calcium ion binding; protein phosphatase binding; ATP binding Biological Process: actin rod formation; protein transport; ER-associated protein catabolic process; unfolded protein response, activation of signaling protein activity; protein folding; unfolded protein response; sequestering of calcium ion; response to hypoxia; innate immune response; regulation of phosphoprotein phosphatase activity; negative regulation of apoptosis Reference #:  P14625 (UniProtKB) Alt. Names/Synonyms: 94 kDa glucose-regulated protein; ECGP; Endoplasmin; endothelial cell (HBMEC) glycoprotein; ENPL; glucose regulated protein, 94 kDa; GP96; gp96 homolog; GRP-94; GRP94; Heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; HSP90B1; TRA1; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen-1 (gp96) Gene Symbols: HSP90B1 Molecular weight: 92,469 Da Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GRP94

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		D26	VRADDEVDVdGTVEE
0	2		D28-ca	ADDEVDVdGTVEEDL
0	2		S42-p	LGKSREGsRtDDEVV
0	1		T44-p	KSREGsRtDDEVVQR
0	1		D59	EEEAIQLDGLNASQI
0	1		K72-u	QIRELREkSEkFAFQ
0	1		K75-a	ELREkSEkFAFQAEV
0	6		K75-u	ELREkSEkFAFQAEV
0	1		S92-p	MMKLIINsLykNkEI
0	4		Y94-p	KLIINsLykNkEIFL
0	8		K95-u	LIINsLykNkEIFLR
0	4		K97-u	INsLykNkEIFLREL
0	2		S106-p	IFLRELIsNAsDALD
0	2		S109-p	RELIsNAsDALDkIR
0	13		K114-u	NAsDALDkIRLISLT
0	1		T133	LSGNEELTVKIKCDk
0	1		K140-a	TVKIKCDkEkNLLHV
0	1		K142-u	KIKCDkEkNLLHVTD
0	1		T148	EkNLLHVTDTGVGMT
0	1		T150	NLLHVTDTGVGMTRE
0	2		K161-u	MTREELVkNLGTIAk
0	12		K168-u	kNLGTIAkSGTSEFL
0	1		T179-p	SEFLNKMtEAQEDGQ
0	1		S187-p	EAQEDGQsTSELIGQ
0	1		Y200-p	GQFGVGFysAFLVAD
0	1		S201-p	QFGVGFysAFLVADK
0	1		T219	TSKHNNDTQHIWESD
0	1		S231	ESDSNEFSVIADPRG
0	1		T248	LGRGTTITLVLkEEA
0	2		K252-u	TTITLVLkEEASDYL
0	4		K265-u	YLELDTIkNLVKkYS
0	1		K270	TIkNLVKKYSQFINF
0	8		K270-u	TIkNLVKkYSQFINF
0	13		S306-p	AKEEKEEsDDEAAVE
1	0		S347-p	KPIWQRPsKEVEEDE
0	5		K360-u	DEYKAFYkSFSKESD
0	4		K404-a	LFDEYGSkkSDyIkL
0	2		K404-u	LFDEYGSkkSDyIkL
0	1		K405-u	FDEYGSkkSDyIkLY
0	1		Y408-p	YGSkkSDyIkLYVRR
0	6		K410-u	SkkSDyIkLYVRRVF
0	1		Y429-p	FHDMMPKyLNFVkGV
0	10		K434-u	PKyLNFVkGVVDSDD
0	4		K455-u	RETLQQHkLLKVIRK
0	6		K467-u	IRKKLVRktLDMIkK
0	1		T468-p	RKKLVRktLDMIkKI
0	2		K473	RktLDMIKKIADDkY
0	2		K473-u	RktLDMIkKIADDkY
0	1		K479-a	IkKIADDkYNDTFWk
0	1		K486-u	kYNDTFWkEFGTNIK
0	1		S544-p	KIYFMAGssRKEAES
0	1		S545-p	IYFMAGssRKEAESS
0	1		S552	sRKEAESSPFVERLL
0	26		K586-a	ALPEFDGkRFQNVAk
0	4		K586-u	ALPEFDGkRFQNVAk
0	3		K593-u	kRFQNVAkEGVKFDE
0	1		K597	NVAkEGVKFDESEKT
0	3		K613-a	ESREAVEkEFEPLLN
0	2		K633-u	ALKDKIEkAVVSQRL
0	1		S637	KIEkAVVSQRLTESP
0	13		Y652-p	CALVASQyGWSGNME
0	5		K663-u	GNMERIMkAQAyQTG
0	1		Y667-p	RIMkAQAyQTGkDIS
0	8		K671-u	AQAyQTGkDISTNyy
0	63		Y677-p	GkDISTNyyASQkKt
0	36		Y678-p	kDISTNyyASQkKtF
0	8		K682-a	TNyyASQkKtFEINP
0	5		K682-u	TNyyASQkKtFEINP
0	2		T684-p	yyASQkKtFEINPRH
0	2		K733-u	GYLLPDTkAyGDRIE
0	1		Y735-p	LLPDTkAyGDRIERM
0	1		T786-p	DEEMDVGtDEEEETA

	mouse
D26-ca	VRADDEVdVdGTVEE
D28-ca	ADDEVdVdGTVEEDL
S42-p	LGKSREGsRtDDEVV
T44-p	KSREGsRtDDEVVQR
D59-ca	EEEAIQLdGLNASQI
K72	QIRELREKSEkFAFQ
K75	ELREKSEKFAFQAEV
K75-u	ELREKSEkFAFQAEV
S92	MMKLIINSLYkNKEI
Y94	KLIINSLYkNKEIFL
K95-u	LIINSLYkNKEIFLR
K97	INSLYkNKEIFLREL
S106-p	IFLRELIsNAsDALD
S109-p	RELIsNAsDALDkIR
K114-u	NAsDALDkIRLISLT
T133-p	LAGNEELtVKIKCDK
K140	tVKIKCDKEKNLLHV
K142	KIKCDKEKNLLHVtD
T148-p	EKNLLHVtDtGVGMT
T150-p	NLLHVtDtGVGMTRE
K161-u	MTREELVkNLGTIAk
K168-u	kNLGTIAkSGTSEFL
T179	SEFLNKMTEAQEDGQ
S187	EAQEDGQSTSELIGQ
Y200	GQFGVGFYSAFLVAD
S201	QFGVGFYSAFLVADK
T219-p	TSKHNNDtQHIWESD
S231-p	ESDSNEFsVIADPRG
T248-p	LGRGTTItLVLKEEA
K252	TTItLVLKEEASDYL
K265-u	YLELDTIkNLVRkYS
K270-a	TIkNLVRkYSQFINF
K270	TIkNLVRKYSQFINF
S306-p	AKEEKEEsDDEAAVE
S347	KPIWQRPSKEVEEDE
K360-u	DEYKAFYkSFSKESD
K404-a	LFDEYGSkKSDYIKL
K404-u	LFDEYGSkKSDYIKL
K405	FDEYGSkKSDYIKLY
Y408	YGSkKSDYIKLYVRR
K410	SkKSDYIKLYVRRVF
Y429	FHDMMPKYLNFVkGV
K434-u	PKYLNFVkGVVDSDD
K455-u	RETLQQHkLLKVIRK
K467	IRKKLVRKTLDMIkK
T468	RKKLVRKTLDMIkKI
K473-a	RKTLDMIkKIADEKY
K473	RKTLDMIKKIADEKY
K479	IkKIADEKYNDTFWK
K486	KYNDTFWKEFGTNIK
S544	KIYFMAGSSRKEAES
S545	IYFMAGSSRKEAESs
S552-p	SRKEAESsPFVERLL
K586-a	ALPEFDGkRFQNVAK
K586	ALPEFDGKRFQNVAK
K593	kRFQNVAKEGVkFDE
K597-a	NVAKEGVkFDESEKT
K613	ESREATEKEFEPLLN
K633	ALKDKIEKAVVsQRL
S637-p	KIEKAVVsQRLTESP
Y652	CALVASQYGWSGNME
K663-u	GNMERIMkAQAYQTG
Y667	RIMkAQAYQTGkDIS
K671-u	AQAYQTGkDISTNyy
Y677-p	GkDISTNyyASQkKt
Y678-p	kDISTNyyASQkKtF
K682-a	TNyyASQkKtFEINP
K682-u	TNyyASQkKtFEINP
T684-p	yyASQkKtFEINPRH
K733	GYLLPDTKAYGDRIE
Y735	LLPDTKAYGDRIERM
T785	GEEMDAGTEEEEEET

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