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Protein Page:
DYRK1B (human)

Overview
DYRK1B a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); CMGC group; DYRK family; Dyrk1 subfamily
Cellular Component: nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transcription coactivator activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; myoblast fusion
Reference #:  Q9Y463 (UniProtKB)
Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1B; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYR1B; DYRK1B; Minibrain-related kinase; MIRK; Mirk protein kinase
Gene Symbols: DYRK1B
Molecular weight: 69,198 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DYRK1B

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 24 Y63-p YKHINEVyYAKKKRR
2 183 Y271-p CQLGQRIyQyIQsRF
2 3539 Y273-p LGQRIyQyIQsRFYR
0 373 S276-p RIyQyIQsRFYRSPE
0 1 Y485-p SDNRTYRysNRYCGG
0 1 S486-p DNRTYRysNRYCGGP
  DYRK1B iso2  
Y63 YKHINEVYYAKKKRR
Y271 CQLGQRIYQYIQSRF
Y273 LGQRIYQYIQSRFYR
S276 RIYQYIQSRFYRSPE
Y445 SDNRTYRYSNRYCGG
S446 DNRTYRYSNRYCGGP
  mouse

 
Y63-p YKHINEVyYAKKKRR
Y271-p CQLGQRIyQyIQsRF
Y273-p LGQRIyQyIQsRFYR
S276-p RIyQyIQsRFYRSPE
Y485 NDNRAYRYSNRYCGG
S486 DNRAYRYSNRYCGGP
  rat

 
Y63 YKHINEVYYAKKKRR
Y271 CQLGQRIYQyIQsRF
Y273-p LGQRIYQyIQsRFYR
S276-p RIYQyIQsRFYRSPE
Y445 SDNRAYRYSNRYCGG
S446 DNRAYRYSNRYCGGP
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