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DYRK1B (human)

Overview DYRK1B a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, CMGC; Protein kinase, dual-specificity; CMGC group; DYRK family; Dyrk1 subfamily Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transcription coactivator activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity Biological Process: positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; myoblast fusion Reference #:  Q9Y463 (UniProtKB) Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1B; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYR1B; DYRK1B; Minibrain-related kinase; MIRK; Mirk protein kinase Gene Symbols: DYRK1B Molecular weight: 69,198 Da Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DYRK1B

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	24		Y63-p	YKHINEVyYAKKKRR
0	190		Y271-p	CQLGQRIyQyIQsRF
0	3508		Y273-p	LGQRIyQyIQsRFYR
0	363		S276-p	RIyQyIQsRFYRSPE
0	1		Y485-p	SDNRTYRysNRYCGG
0	1		S486-p	DNRTYRysNRYCGGP

	DYRK1B iso2
Y63	YKHINEVYYAKKKRR
Y271	CQLGQRIYQYIQSRF
Y273	LGQRIYQYIQSRFYR
S276	RIYQYIQSRFYRSPE
Y445	SDNRTYRYSNRYCGG
S446	DNRTYRYSNRYCGGP

	mouse
Y63-p	YKHINEVyYAKKKRR
Y271-p	CQLGQRIyQyIQsRF
Y273-p	LGQRIyQyIQsRFYR
S276-p	RIyQyIQsRFYRSPE
Y485	NDNRAYRYSNRYCGG
S486	DNRAYRYSNRYCGGP

	rat
Y63	YKHINEVYYAKKKRR
Y271	CQLGQRIYQyIQSRF
Y273-p	LGQRIYQyIQSRFYR
S276	RIYQyIQSRFYRSPE
Y445	SDNRAYRYSNRYCGG
S446	DNRAYRYSNRYCGGP

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