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Protein Page:
EHHADH (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
EHHADH 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secondary Metabolites Metabolism - limonene and pinene degradation; EC 5.3.3.8; Lyase; EC 1.1.1.35; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - tryptophan; Isomerase; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Oxidoreductase; Lipid Metabolism - fatty acid; EC 4.2.1.17; Mitochondrial; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - lysine degradation
Cellular Component: mitochondrion; intracellular membrane-bound organelle; cytoplasm; nucleolus; peroxisome; nucleus
Molecular Function: enzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; nucleotide binding; coenzyme binding; 3-hydroxyacyl-CoA dehydrogenase activity; receptor binding
Biological Process: fatty acid beta-oxidation; internal protein amino acid acetylation
Reference #:  Q08426 (UniProtKB)
Alt. Names/Synonyms: 3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; ECHD; ECHP; EHHADH; Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional protein, peroxisomal; L-PBE; LBFP; LBP; MGC120586; PBE; PBFE; Peroxisomal bifunctional enzyme; peroxisomal enoyl-CoA hydratase
Gene Symbols: EHHADH
Molecular weight: 79,495 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
Select Structure to View Below

EHHADH
Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: K165‑a, K346‑a, K584‑a

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 T27-p PVNAISTtLLRDIKE
0 1 K38 DIKEGLQKAVIDHTI
0 1 E117 HYRIAHAEAQVGLPE
0 1 T153-p PAALDLItSGRRILA
0 1 K165-a ILADEALkLGILDkV
0 1 K165 ILADEALKLGILDkV
0 1 K171-a LkLGILDkVVNSDPV
0 1 N174 GILDkVVNSDPVEEA
0 1 N174 GILDkVVNSDPVEEA
0 1 Q191 FAQRVSDQPLESRRL
0 1 Q191 FAQRVSDQPLESRRL
0 3 K219-a IFSEALLkMRRQHPG
0 7 Q242 RAVQAAVQyPYEVGI
0 2 Y243-p AVQAAVQyPYEVGIK
0 1 K250 yPYEVGIKKEEELFL
0 1 R276 QYAFFAERKANKWST
0 1 R276 QYAFFAERKANKWST
0 5 K280 FAERKANKWSTPSGA
0 1 K280 FAERKANKWSTPSGA
0 1 S288 WSTPSGASWKTASAR
0 1 S298 TASARPVSSVGVVGL
0 1 S299 ASARPVSSVGVVGLG
0 1 T307 VGVVGLGTMGRGIVI
0 4 N331 IAVDSDKNQLATANk
0 1 N331 IAVDSDKNQLATANk
0 16 N337 KNQLATANkMITSVL
0 6 K338-a NQLATANkMITSVLE
0 1 K338 NQLATANKMITSVLE
0 6 K346-a MITSVLEkEASkMQQ
0 1 K346 MITSVLEKEASkMQQ
0 4 K350-a VLEkEASkMQQSGHP
0 1 K350 VLEkEASKMQQSGHP
0 1 S359-p QQSGHPWsGPKPRLT
0 9 G360 QSGHPWsGPKPRLTS
0 21 K464-a ATVMNLSkKIKKIGV
0 1 K464 ATVMNLSKKIKKIGV
0 1 K468 NLSkKIKKIGVVVGN
0 23 K532-a AGLDVGWkSRKGQGL
0 1 K532 AGLDVGWKSRKGQGL
0 2 T548-p GPTLLPGtPARKRGN
0 1 K574 ELGRFGQKTGkGWyQ
0 2 K577-a RFGQKTGkGWyQyDk
0 1 K577 RFGQKTGKGWyQyDk
0 1 Y580-p QKTGkGWyQyDkPLG
0 12 Y582-p TGkGWyQyDkPLGRI
0 29 K584-a kGWyQyDkPLGRIHk
0 1 K584 kGWyQyDKPLGRIHk
0 3 K591-a kPLGRIHkPDPWLSk
0 4 K598-a kPDPWLSkFLSRYRK
0 2 E610 YRKTHHIEPRTISQD
0 1 Y625 EILERCLYSLINEAF
0 1 Y654 DVVYLHGYGWPRHKG
0 2 S714-p PPLKEWQsLAGSPSS
0 16 K722-a LAGSPSSkL______
  EHHADH iso3  
T27 PVNAISTTLLRDIKE
K38 DIKEGLQKAGRDHTI
D117 HYRIAHADAQVGLPE
T153 PAALDLITSGRRILA
K165 ILADEALKLGILDKV
K165 ILADEALKLGILDKV
K171 LKLGILDKVVNSDPV
N174 GILDKVVNSDPVEEA
N174 GILDKVVNSDPVEEA
Q191 FAQRVSDQPLESRRL
Q191 FAQRVSDQPLESRRL
K219 IFSEALLKMRRQHPG
Q242 RAVQAAVQYPYEVGI
Y243 AVQAAVQYPYEVGIK
K250 YPYEVGIKKEEELFL
R276 QYAFFAERKANKWST
R276 QYAFFAERKANKWST
K280 FAERKANKWSTPSGA
K280 FAERKANKWSTPSGA
S288 WSTPSGASWKTASAR
S298 TASARPVSSVGVVGL
S299 ASARPVSSVGVVGLG
T307 VGVVGLGTMGRGIVI
N331 IGVDSDKNQLATANK
N331 IGVDSDKNQLATANK
N337 KNQLATANKMITSVL
K338 NQLATANKMITSVLE
K338 NQLATANKMITSVLE
K346 MITSVLEKEASKMQQ
K346 MITSVLEKEASKMQQ
K350 VLEKEASKMQQSGHP
K350 VLEKEASKMQQSGHP
S359 QQSGHPWSGPKPRLT
G360 QSGHPWSGPKPRLTS
K464 ATVMNLSKKIKKIGV
K464 ATVMNLSKKIKKIGV
K468 NLSKKIKKIGVVVGN
K532 AGLDVGWKSRKGQGL
K532 AGLDVGWKSRKGQGL
T548 GPTLLPGTPARKRGN
K574 ELGRFGQKTGKGWYQ
K577 RFGQKTGKGWYQYDK
K577 RFGQKTGKGWYQYDK
Y580 QKTGKGWYQYDKPLG
Y582 TGKGWYQYDKPLGRI
K584 KGWYQYDKPLGRIHK
K584 KGWYQYDKPLGRIHK
K591 KPLGRIHKPDPWLST
T598 KPDPWLSTFLSRYRK
E610 YRKPHHIEPRTISQD
Y625-p EILERCLySLINEAF
Y654-p DVVYLHGyGCARHKG
S714 PPLKEWQSLAGSPSS
K722 LAGSPSSKL______
  mouse

 
- under review  
K38-u EVRNGLQkASLDHTV
K115-a HYRIANAkARVGFPE
T151 PVALDLITSGRHIST
K163 ISTDEALKLGILDVV
K163-u ISTDEALkLGILDVV
V169 LkLGILDVVVkSDPV
K172-a GILDVVVkSDPVEEA
K172-u GILDVVVkSDPVEEA
K189-a FAQTVIGkPIEPRRI
K189-u FAQTVIGkPIEPRRI
K217 VFAEAIAKVRKQYPG
K240-a RSVQASVkHPYEVAI
H241 SVQASVkHPYEVAIk
K248-u HPYEVAIkEEAKLFM
K274-a QYAFFAEkSANkWST
K274-u QYAFFAEkSANkWST
K278-a FAEkSANkWSTPSGA
K278-u FAEkSANkWSTPSGA
S286-p WSTPSGAsWKTASAQ
S296-p TASAQPVssVGVLGL
S297-p ASAQPVssVGVLGLG
T305-p VGVLGLGtMGRGIAI
K329-a VAVESDPkQLDTAkk
K329-u VAVESDPkQLDTAkk
K335-a PkQLDTAkkIITSTL
K336-a kQLDTAkkIITSTLE
K336-u kQLDTAkkIITSTLE
K344-a IITSTLEkEASkSGQ
K344-u IITSTLEkEASkSGQ
K348-a TLEkEASkSGQASAk
K348-u TLEkEASkSGQASAk
A354 SkSGQASAkPNLRFS
K355-a kSGQASAkPNLRFSS
K459-a ATVMSLSkRIGkIGV
K459-u ATVMSLSkRIGkIGV
K463-u SLSkRIGkIGVVVGN
K527-a AGLDVGWkVRKGQGL
K527-u AGLDVGWkVRKGQGL
T543-p GPSLPPGtPTRKRGN
K569-a EAGRFGQkTGkGWYQ
K572-a RFGQkTGkGWYQYDk
K572-u RFGQkTGkGWYQYDk
Y575 QkTGkGWYQYDkPLG
Y577 TGkGWYQYDkPLGRI
K579-a kGWYQYDkPLGRIHk
K579-u kGWYQYDkPLGRIHk
K586-a kPLGRIHkPDPWLSE
E593 kPDPWLSEFLSQYRE
K605-a YRETHHIkQRSISKE
Y620 EILERCLYSLINEAF
Y649 DVIYLHGYGWPRHVG
S709-p PPLKEWQsLAGPHSS
K717-a LAGPHSSkL______
  rat

 
- under review  
K38 EVRNGLQKAGSDHTV
K116 HYRIANAKARVGLPE
T152 PVALDLITSGKYLSA
R164 LSADEALRLGILDAV
R164 LSADEALRLGILDAV
A170 LRLGILDAVVKSDPV
K173 GILDAVVKSDPVEEA
K173 GILDAVVKSDPVEEA
K190 FAQKIIDKPIEPRRI
K190 FAQKIIDKPIEPRRI
K218 VFAEAIAKVRKQYPG
K241 RSIQASVKHPYEVGI
H242 SIQASVKHPYEVGIK
K249 HPYEVGIKEEEKLFM
K275 QYAFFAEKSANKWST
K275 QYAFFAEKSANKWST
K279 FAEKSANKWSTPSGA
K279 FAEKSANKWSTPSGA
S287 WSTPSGASWKTASAQ
S297 TASAQPVSSVGVLGL
S298 ASAQPVSSVGVLGLG
T306-p VGVLGLGtMGRGIAI
K330 VAVESDPKQLDAAKK
K330 VAVESDPKQLDAAKK
K336 PKQLDAAKKIITFTL
K337 KQLDAAKKIITFTLE
K337 KQLDAAKKIITFTLE
K345 IITFTLEKEASRAHQ
K345 IITFTLEKEASRAHQ
R349 TLEKEASRAHQNGQA
R349 TLEKEASRAHQNGQA
A358 HQNGQASAKPKLRFS
K359 QNGQASAKPKLRFSS
K463 ATVMSLSKKIGKIGV
K463 ATVMSLSKKIGKIGV
K467 SLSKKIGKIGVVVGN
K531 AGLDVGWKIRKGQGL
K531 AGLDVGWKIRKGQGL
T547 GPSLPPGTPVRKRGN
K573 EAGRFGQKTGKGWYQ
K576 RFGQKTGKGWYQyDK
K576 RFGQKTGKGWYQyDK
Y579 QKTGKGWYQyDKPLG
Y581-p TGKGWYQyDKPLGRI
K583 KGWYQyDKPLGRIHK
K583 KGWYQyDKPLGRIHK
K590 KPLGRIHKPDPWLST
T597 KPDPWLSTFLSQYRE
E609 YREVHHIEQRTISKE
Y624 EILERCLYSLINEAF
Y653 DVIYLHGYGWPRHKG
S713 PPLKEWQSLAGPHGS
K721 LAGPHGSKL______
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