Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Kinase, other
Chromosomal Location of Human Ortholog: 4q13.3-q21.1
Cellular Component: cytosol; nucleus
Molecular Function: protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; phosphotransferase activity, alcohol group as acceptor; ATP binding
Biological Process: pyrimidine base metabolic process; nucleotide biosynthetic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; phosphorylation; purine base metabolic process; purine salvage; deoxyribonucleoside monophosphate biosynthetic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.