Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
dCK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
dCK Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine
Cellular Component: cytosol; nucleus
Molecular Function: protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; phosphotransferase activity, alcohol group as acceptor; ATP binding
Biological Process: pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleotide biosynthetic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside salvage; phosphorylation; purine base metabolic process; purine salvage; deoxyribonucleoside monophosphate biosynthetic process
Reference #:  P27707 (UniProtKB)
Alt. Names/Synonyms: DCK; Deoxycytidine kinase; MGC117410; MGC138632
Gene Symbols: DCK
Molecular weight: 30,519 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Select Structure to View Below

dCK

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Sites Implicated In
enzymatic activity, induced: S74‑p
phosphorylation: T3‑p, S11‑p, S15‑p
protein conformation: S74‑p
protein stabilization: T3‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 3 T3-p _____MAtPPKRsCP
0 3 S8-p MAtPPKRsCPsFsAs
4 20 S11-p PPKRsCPsFsAssEG
0 15 S13-p KRsCPsFsAssEGtR
0 3 A14 RsCPsFsAssEGtRI
4 13 S15-p sCPsFsAssEGtRIK
0 5 S16-p CPsFsAssEGtRIKk
0 2 T19-p FsAssEGtRIKkISI
0 1 K23-ub sEGtRIKkISIEGNI
0 2 K34-ub EGNIAAGksTFVNIL
0 1 S35-p GNIAAGksTFVNILK
0 7 S63-p ARWCNVQstQDEFEE
0 6 T64-p RWCNVQstQDEFEEL
1 11 T72-p QDEFEELtMsQKNGG
0 1 M73 DEFEELtMsQKNGGN
11 105 S74-p EFEELtMsQKNGGNV
0 1 K88-ac VLQMMYEkPERWSFT
0 3 K115-ub QLASLNGkLkDAEkP
0 51 K117-ub ASLNGkLkDAEkPVL
0 5 K121-ub GkLkDAEkPVLFFER
0 1 Y190-p ETCLHRIyLRGRNEE
0 1 Y204-p EQGIPLEyLEKLHYK
0 1 K222-ub WLLHRTLkTNFDYLQ
0 17 K243-ub LDVNEDFkDKYESLV
0 1 K245 VNEDFkDKYESLVEk
0 1 K252-ac KYESLVEkVKEFLST
0 3 K252-ub KYESLVEkVKEFLST
  mouse

 
T3 _____MATPPKRFCP
F8 MATPPKRFCPsPsts
S11-p PPKRFCPsPstssEG
S13-p KRFCPsPstssEGTR
T14-p RFCPsPstssEGTRI
S15-p FCPsPstssEGTRIK
S16-p CPsPstssEGTRIKK
T19 PstssEGTRIKKISI
K23 sEGTRIKKISIEGNI
K34 EGNIAAGKSTFVNIL
S35 GNIAAGKSTFVNILK
S63 ARWCNVQSTQEEFEE
T64 RWCNVQSTQEEFEEL
T72 QEEFEELTtsQKSGG
T73-p EEFEELTtsQKSGGN
S74-p EFEELTtsQKSGGNV
K88 VLQMMYEKPERWSFT
K115 QLASLNGKLkDAEkP
K117-ub ASLNGKLkDAEkPVL
K121-ub GKLkDAEkPVLFFER
Y190 EKCLNRIYLRGRNEE
Y204 EQGIPLEYLEKLHYK
K222 WLLHRTLKTSFDYLQ
K243-ub LDVNEDFkDkHESLV
K245-ub VNEDFkDkHESLVEK
K252 kHESLVEKVKEFLST
K252 kHESLVEKVKEFLST
  rat

 
T3 _____MATPPKRFCS
F8 MATPPKRFCSsPSTS
S11-p PPKRFCSsPSTSSEG
S13 KRFCSsPSTSSEGTR
T14 RFCSsPSTSSEGTRI
S15 FCSsPSTSSEGTRIK
S16 CSsPSTSSEGTRIKK
T19 PSTSSEGTRIKKISI
K23 SEGTRIKKISIEGNI
K34 EGNIAAGKSTFVNIL
S35 GNIAAGKSTFVNILK
S63 ARWCNVQSTQDEFEE
T64 RWCNVQSTQDEFEEL
T72 QDEFEELTTSQKSGG
T73 DEFEELTTSQKSGGN
S74 EFEELTTSQKSGGNV
K88 VLQMMYEKPERWSFI
S115 QLASLNGSLRDAEKP
R117 ASLNGSLRDAEKPVL
K121 GSLRDAEKPVLFFER
Y190 EKCLNRIYIRGRDEE
Y204 EQGIPLEYLEKLHYK
K222 WLLHRTLKTNFEYLQ
K243 LDVNLDFKDKEESLV
K245 VNLDFKDKEESLVEK
K252 KEESLVEKVKEFLST
K252 KEESLVEKVKEFLST
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.