Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57. Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Belongs to the calreticulin family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Calcium-binding protein; Secreted; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; extracellular space; sarcoplasmic reticulum lumen; cell surface; endoplasmic reticulum lumen; endoplasmic reticulum; acrosome; cytosol; polysome; proteinaceous extracellular matrix; perinuclear region of cytoplasm; cytoplasm; intracellular; nucleus; external side of plasma membrane
Molecular Function: hormone binding; zinc ion binding; complement component C1q binding; unfolded protein binding; calcium ion binding; peptide binding; mRNA binding; integrin binding; protein binding; DNA binding; androgen receptor binding; chaperone binding; ubiquitin protein ligase binding; iron ion binding; carbohydrate binding
Biological Process: protein maturation via protein folding; protein folding; regulation of meiosis; negative regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; cardiac muscle cell differentiation; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of transcription, DNA-dependent; positive regulation of phagocytosis; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein export from nucleus; cortical actin cytoskeleton organization and biogenesis; cell cycle arrest; response to drug; negative regulation of steroid hormone receptor signaling pathway; protein stabilization; unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell cycle; response to testosterone stimulus; post-translational protein modification; peptide antigen assembly with MHC class I protein complex; cellular calcium ion homeostasis; negative regulation of retinoic acid receptor signaling pathway; negative regulation of neuron differentiation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; sequestering of calcium ion; glucocorticoid receptor signaling pathway; negative regulation of translation; spermatogenesis; protein amino acid N-linked glycosylation via asparagine; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.