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CK1-A (human)

Overview CK1-A an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; Kinase, protein; CK1 group; CK1 family Cellular Component: centrosome; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; ribonucleoprotein complex; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity Biological Process: mitosis; cell surface receptor linked signal transduction; Wnt receptor signaling pathway; cell division; cell morphogenesis; signal transduction; protein amino acid phosphorylation Reference #:  P48729 (UniProtKB) Alt. Names/Synonyms: casein kinase 1, alpha 1; Casein kinase I isoform alpha; CK1; CKI-alpha; CSNK1A1; down-regulated in lung cancer; HLCDGP1; KC1A; PRO2975 Gene Symbols: CSNK1A1 Molecular weight: 38,915 Da Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states CST Pathways:  Hedgehog Signaling  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CK1-A Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S218‑p, S242‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S3-p	_____MAsSSGSkAE
0	1		K8-a	MAsSSGSkAEFIVGG
0	1		Y17-p	EFIVGGKyKLVRKIG
0	1		Y32-p	SGSFGDIyLAINITN
0	11		K62-u	PQLLYESkLYkILQG
0	3		K65-u	LYESkLYkILQGGVG
0	1		Y85-p	WYGQEKDyNVLVMDL
0	1		S105-p	EDLFNFCsRRFTMKT
0	1		K138-u	NFIHRDIkPDNFLMG
0	1		-	gap
0	2		K162-u	LIDFGLAkKYRDNRT
0	1		T184-p	EDKNLTGtARYASIN
0	1		S199-p	AHLGIEQsRRDDMES
1	0		S218-p	LMYFNRTsLPWQGLk
0	4		K225-u	sLPWQGLkAATkKQK
0	1		K229-u	QGLkAATkKQKYEKI
1	0		S242-p	KISEKKMsTPVEVLC
0	1		K250	TPVEVLCKGFPAEFA
0	29		Y294-p	TLNHQYDyTFDWTML
0	7		K302-u	TFDWTMLkQkAAQQA
0	6		K304-u	DWTMLkQkAAQQAAs
0	1		S311-p	kAAQQAAsSSGQGQQ
0	15		T321-p	GQGQQAQtPTGkQtD
0	1		T323	GQQAQtPTGkQtDKT
0	1		K325-u	QAQtPTGkQtDKTKs
0	1		T327-p	QtPTGkQtDKTKsNM
0	1		S332-p	kQtDKTKsNMKGF__

	CK1-A iso2
S3	_____MASSSGSKAE
K8	MASSSGSKAEFIVGG
Y17	EFIVGGKYKLVRKIG
Y32	SGSFGDIYLAINITN
K62	PQLLYESKLYKILQG
K65	LYESKLYKILQGGVG
Y85	WYGQEKDYNVLVMDL
S105	EDLFNFCSRRFTMKT
K138	NFIHRDIKPDNFLMG
S156-p	HCNKCLEsPVGKRKR
K190	LIDFGLAKKYRDNRT
T212	EDKNLTGTARYASIN
S227	AHLGIEQSRRDDMES
S246	LMYFNRTSLPWQGLK
K253	SLPWQGLKAATKKQK
K257	QGLKAATKKQKYEKI
S270	KISEKKMSTPVEVLC
K278	TPVEVLCKGFPAEFA
Y322	TLNHQYDYTFDWTML
K330	TFDWTMLKQKAAQQA
K332	DWTMLKQKAAQQAAS
S339	KAAQQAASSSGQGQQ
T349	GQGQQAQTPTGKQTD
T351	GQQAQTPTGKQTDKT
K353	QAQTPTGKQTDKTKS
T355	QTPTGKQTDKTKSNM
S360	KQTDKTKSNMKGF__

	CK1-A iso3
S3	_____MASSSGSKAE
K8	MASSSGSKAEFIVGG
Y17	EFIVGGKYKLVRKIG
Y32	SGSFGDIYLAINITN
K62	PQLLYESKLYKILQG
K65	LYESKLYKILQGGVG
Y85	WYGQEKDYNVLVMDL
S105	EDLFNFCSRRFTMKT
K138	NFIHRDIKPDNFLMG
-	gap
K162	LIDFGLAKKYRDNRT
T184	EDKNLTGTARYASIN
S199	AHLGIEQSRRDDMES
S218	LMYFNRTSLPWQGLK
K225	SLPWQGLKAATKKQK
K229	QGLKAATKKQKYEKI
S242	KISEKKMSTPVEVLC
K250	TPVEVLCKGFPAEFA
Y294	TLNHQYDYTFDWTML
K302	TFDWTMLKQKAAQQA
K304	DWTMLKQKAAQQAAS
S311	KAAQQAASSSGQGQQ
T321-p	GQGQQAQtPTGF___
T323	GQQAQtPTGF_____
-	gap
-	gap
-	gap

	mouse ► Hide Isoforms
S3	_____MASSSGSKAE
K8	MASSSGSKAEFIVGG
Y17	EFIVGGKYKLVRKIG
Y32	SGSFGDIYLAINITN
K62-u	PQLLYESkLYkILQG
K65-u	LYESkLYkILQGGVG
Y85	WYGQEKDYNVLVMDL
S105	EDLFNFCSRRFTMKT
K138	NFIHRDIKPDNFLMG
-	gap
K162	LIDFGLAKKYRDNRT
T184	EDKNLTGTARYASIN
S199	AHLGIEQSRRDDMES
S218	LMYFNRTSLPWQGLk
K225-u	SLPWQGLkAATKKQK
K229	QGLkAATKKQKYEKI
S242	KISEKKMSTPVEVLC
K250-u	TPVEVLCkGFPAEFA
Y294-p	TLNHQYDyTFDWTML
K302-u	TFDWTMLkQkAAQQA
K304-u	DWTMLkQkAAQQAAS
S311	kAAQQAASSSGQGQQ
T321	GQGQQAQTPTGKQTD
T323	GQQAQTPTGKQTDKT
K325	QAQTPTGKQTDKTKS
T327	QTPTGKQTDKTKSNM
S332	KQTDKTKSNMKGF__

	CK1-A iso2
S3	_____MASSSGSKAE
K8	MASSSGSKAEFIVGG
Y17	EFIVGGKYKLVRKIG
Y32	SGSFGDIYLAINITN
K62	PQLLYESKLYKILQG
K65	LYESKLYKILQGGVG
Y85	WYGQEKDYNVLVMDL
S105	EDLFNFCSRRFTMKT
K138	NFIHRDIKPDNFLMG
-	gap
K162	LIDFGLAKKYRDNRT
T184	EDKNLTGTARYASIN
S199	AHLGIEQSRRDDMES
S218	LMYFNRTSLPWQGLK
K225	SLPWQGLKAATKKQK
K229	QGLKAATKKQKYEKI
S242	KISEKKMSTPVEVLC
K250	TPVEVLCKGFPAEFA
Y294	TLNHQYDYTFDWTML
K302	TFDWTMLKQKAAQQA
K304	DWTMLKQKAAQQAAS
S311	KAAQQAASSSGQGQQ
T321-p	GQGQQAQtPTGF___
T323	GQQAQtPTGF_____
-	gap
-	gap
-	gap

	rat
S3	_____MASSSGSKAE
K8	MASSSGSKAEFIVGG
Y17	EFIVGGKYKLVRKIG
Y32	SGSFGDIYLAINITN
K62	PQLLYESKLYKILQG
K65	LYESKLYKILQGGVG
Y85	WYGQGKDYNVLVMDL
S105	EDLFNFCSRRFTMKT
K138	NFIHRDIKPDNFLMG
-	gap
K162	LIDFGLAKKYRDNRT
T184	EDKNLTGTARYASIN
S199	AHLGIEQSRRDDMES
S218	LMYFNRTSLPWQGLK
K225	SLPWQGLKAATKKQK
K229	QGLKAATKKQKYEKI
S242	KISEKKMSTPVEVLC
K250	TPVEVLCKGFPAEFA
Y294	TLNHQYDYTFDWTML
K302	TFDWTMLKQKAAQQA
K304	DWTMLKQKAAQQAAS
S311	KAAQQAASSSGQGQQ
T321-p	GQGQQAQtPtGF___
T323-p	GQQAQtPtGF_____
-	gap
-	gap
-	gap

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