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Protein Page:
CK1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CK1A an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CK1; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family
Cellular Component: centrosome; membrane; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity
Biological Process: mitosis; cell surface receptor linked signal transduction; Wnt receptor signaling pathway; signal transduction; protein amino acid phosphorylation
Reference #:  P48729 (UniProtKB)
Alt. Names/Synonyms: casein kinase 1, alpha 1; Casein kinase I isoform alpha; CK1; CKI-alpha; CSNK1A1; down-regulated in lung cancer; HLCDGP1; KC1A; PRO2975
Gene Symbols: CSNK1A1
Molecular weight: 38,915 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CK1A

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
molecular association, regulation: S218‑p, S242‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S3-p _____MAssSGSkAE
0 1 S4-p ____MAssSGSkAEF
0 1 K8-ac MAssSGSkAEFIVGG
0 1 Y17-p EFIVGGKyKLVRKIG
0 1 Y32-p SGSFGDIyLAINITN
0 11 K62-ub PQLLYESkLYkILQG
0 3 K65-ub LYESkLYkILQGGVG
0 1 Y85-p WYGQEKDyNVLVMDL
0 1 S105-p EDLFNFCsRRFTMKT
0 1 K138-ub NFIHRDIkPDNFLMG
0 2 - gap
0 2 K162-ub LIDFGLAkKYRDNRT
0 1 T184-p EDKNLTGtARYASIN
0 1 S199-p AHLGIEQsRRDDMES
1 0 S218-p LMYFNRTsLPWQGLk
0 4 K225-ub sLPWQGLkAATkKQK
0 1 K229-ub QGLkAATkKQKYEKI
1 0 S242-p KISEKKMsTPVEVLC
0 1 K250 TPVEVLCKGFPAEFA
0 36 Y294-p TLNHQYDyTFDWTML
0 7 K302-ub TFDWTMLkQkAAQQA
0 6 K304-ub DWTMLkQkAAQQAAs
0 1 S311-p kAAQQAAsSsGQGQQ
0 1 S313-p AQQAAsSsGQGQQAQ
1 17 T321-p GQGQQAQtPTGkQtD
0 1 T323 GQQAQtPTGkQtDKT
0 1 K325-ub QAQtPTGkQtDKTKs
0 1 T327-p QtPTGkQtDKTKsNM
0 1 S332-p kQtDKTKsNMKGF__
  CK1A iso2  
S3 _____MASSSGSKAE
S4 ____MASSSGSKAEF
K8 MASSSGSKAEFIVGG
Y17 EFIVGGKYKLVRKIG
Y32 SGSFGDIYLAINITN
K62 PQLLYESKLYKILQG
K65 LYESKLYKILQGGVG
Y85 WYGQEKDYNVLVMDL
S105 EDLFNFCSRRFTMKT
K138 NFIHRDIKPDNFLMG
S156-p HCNKCLEsPVGKRKR
K190 LIDFGLAKKYRDNRT
T212 EDKNLTGTARYASIN
S227 AHLGIEQSRRDDMES
S246 LMYFNRTSLPWQGLK
K253 SLPWQGLKAATKKQK
K257 QGLKAATKKQKYEKI
S270 KISEKKMSTPVEVLC
K278 TPVEVLCKGFPAEFA
Y322 TLNHQYDYTFDWTML
K330 TFDWTMLKQKAAQQA
K332 DWTMLKQKAAQQAAS
S339 KAAQQAASSSGQGQQ
S341 AQQAASSSGQGQQAQ
T349 GQGQQAQTPTGKQTD
T351 GQQAQTPTGKQTDKT
K353 QAQTPTGKQTDKTKS
T355 QTPTGKQTDKTKSNM
S360 KQTDKTKSNMKGF__
  CK1A iso3  
S3 _____MASSSGSKAE
S4 ____MASSSGSKAEF
K8 MASSSGSKAEFIVGG
Y17 EFIVGGKYKLVRKIG
Y32 SGSFGDIYLAINITN
K62 PQLLYESKLYKILQG
K65 LYESKLYKILQGGVG
Y85 WYGQEKDYNVLVMDL
S105 EDLFNFCSRRFTMKT
K138 NFIHRDIKPDNFLMG
- gap
K162 LIDFGLAKKYRDNRT
T184 EDKNLTGTARYASIN
S199 AHLGIEQSRRDDMES
S218 LMYFNRTSLPWQGLK
K225 SLPWQGLKAATKKQK
K229 QGLKAATKKQKYEKI
S242 KISEKKMSTPVEVLC
K250 TPVEVLCKGFPAEFA
Y294 TLNHQYDYTFDWTML
K302 TFDWTMLKQKAAQQA
K304 DWTMLKQKAAQQAAS
S311 KAAQQAASSSGQGQQ
S313 AQQAASSSGQGQQAQ
T321-p GQGQQAQtPTGF___
T323 GQQAQtPTGF_____
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S3 _____MASSSGSKAE
S4 ____MASSSGSKAEF
K8 MASSSGSKAEFIVGG
Y17 EFIVGGKYKLVRKIG
Y32 SGSFGDIYLAINITN
K62-ub PQLLYESkLYkILQG
K65-ub LYESkLYkILQGGVG
Y85 WYGQEKDYNVLVMDL
S105 EDLFNFCSRRFTMKT
K138 NFIHRDIKPDNFLMG
- gap
K162 LIDFGLAKKYRDNRT
T184 EDKNLTGTARYASIN
S199 AHLGIEQSRRDDMES
S218 LMYFNRTSLPWQGLk
K225-ub SLPWQGLkAATKKQK
K229 QGLkAATKKQKYEKI
S242 KISEKKMSTPVEVLC
K250-ub TPVEVLCkGFPAEFA
Y294-p TLNHQYDyTFDWTML
K302-ub TFDWTMLkQkAAQQA
K304-ub DWTMLkQkAAQQAAS
S311 kAAQQAASSSGQGQQ
S313 AQQAASSSGQGQQAQ
T321 GQGQQAQTPTGKQTD
T323 GQQAQTPTGKQTDKT
K325 QAQTPTGKQTDKTKS
T327 QTPTGKQTDKTKSNM
S332 KQTDKTKSNMKGF__
  CK1A iso2  
S3 _____MASSSGSKAE
S4 ____MASSSGSKAEF
K8 MASSSGSKAEFIVGG
Y17 EFIVGGKYKLVRKIG
Y32 SGSFGDIYLAINITN
K62 PQLLYESKLYKILQG
K65 LYESKLYKILQGGVG
Y85 WYGQEKDYNVLVMDL
S105 EDLFNFCSRRFTMKT
K138 NFIHRDIKPDNFLMG
- gap
K162 LIDFGLAKKYRDNRT
T184 EDKNLTGTARYASIN
S199 AHLGIEQSRRDDMES
S218 LMYFNRTSLPWQGLK
K225 SLPWQGLKAATKKQK
K229 QGLKAATKKQKYEKI
S242 KISEKKMSTPVEVLC
K250 TPVEVLCKGFPAEFA
Y294 TLNHQYDYTFDWTML
K302 TFDWTMLKQKAAQQA
K304 DWTMLKQKAAQQAAS
S311 KAAQQAASSSGQGQQ
S313 AQQAASSSGQGQQAQ
T321-p GQGQQAQtPTGF___
T323 GQQAQtPTGF_____
- gap
- gap
- gap
  rat

 
S3 _____MASSSGSKAE
S4 ____MASSSGSKAEF
K8 MASSSGSKAEFIVGG
Y17 EFIVGGKYKLVRKIG
Y32 SGSFGDIYLAINITN
K62 PQLLYESKLYKILQG
K65 LYESKLYKILQGGVG
Y85 WYGQGKDYNVLVMDL
S105 EDLFNFCSRRFTMKT
K138 NFIHRDIKPDNFLMG
- gap
K162 LIDFGLAKKYRDNRT
T184 EDKNLTGTARYASIN
S199 AHLGIEQSRRDDMES
S218 LMYFNRTSLPWQGLK
K225 SLPWQGLKAATKKQK
K229 QGLKAATKKQKYEKI
S242 KISEKKMSTPVEVLC
K250 TPVEVLCKGFPAEFA
Y294 TLNHQYDYTFDWTML
K302 TFDWTMLKQKAAQQA
K304 DWTMLKQKAAQQAAS
S311 KAAQQAASSSGQGQQ
S313 AQQAASSSGQGQQAQ
T321-p GQGQQAQtPtGF___
T323-p GQQAQtPtGF_____
- gap
- gap
- gap
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