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Protein Page:
14-3-3 gamma (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
14-3-3 gamma Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasmic vesicle membrane; membrane; cytosol
Molecular Function: protein domain specific binding; insulin-like growth factor receptor binding; protein kinase C inhibitor activity; protein binding; protein kinase C binding; receptor tyrosine kinase binding
Biological Process: cellular response to insulin stimulus; apoptosis; regulation of neuron differentiation; regulation of signal transduction; negative regulation of protein kinase activity; regulation of synaptic plasticity; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein targeting
Reference #:  P61981 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 gamma; 14-3-3 protein gamma; 14-3-3 protein gamma, N-terminally processed; 14-3-3GAMMA; 1433G; KCIP-1; Protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; YWHAG
Gene Symbols: YWHAG
Molecular weight: 28,303 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Crosstalk between PTMs  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

14-3-3 gamma

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S59‑p
molecular association, regulation: S59‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 22 K10-ub DREQLVQkARLAEQA
0 7 Y20-p LAEQAERyDDMAAAM
0 1 K28 DDMAAAMKNVtELNE
0 1 T31-p AAAMKNVtELNEPLs
0 2 S38-p tELNEPLsNEERNLL
0 15 S46-p NEERNLLsVAykNVV
0 8 Y49-p RNLLsVAykNVVGAR
1 5 K50-ac NLLsVAykNVVGARR
0 150 K50-ub NLLsVAykNVVGARR
2 8 S59-p VVGARRSsWRVISsI
0 3 S65-p SsWRVISsIEQkTsA
0 1 K69-ac VISsIEQkTsADGNE
0 27 K69-ub VISsIEQkTsADGNE
0 7 S71-p SsIEQkTsADGNEkK
0 11 K77-ub TsADGNEkKIEMVRA
0 1 K78 sADGNEkKIEMVRAY
0 1 K88 MVRAYREKIEKELEA
0 1 K91 AYREKIEKELEAVCQ
0 2 K110-ub LLDNYLIkNCSEtQy
0 1 S113 NYLIkNCSEtQyEsk
0 2 T115-p LIkNCSEtQyEskVF
0 63 Y117-p kNCSEtQyEskVFYL
0 3 S119-p CSEtQyEskVFYLkM
0 38 K120-ac SEtQyEskVFYLkMk
0 2 K120 SEtQyEsKVFYLkMk
0 1 K120-sc SEtQyEskVFYLkMk
0 4 K125-ac EskVFYLkMkGDYyR
0 72 K125-ub EskVFYLkMkGDYyR
0 9 K127-ub kVFYLkMkGDYyRyL
0 35 Y131-p LkMkGDYyRyLAEVA
0 4 Y133-p MkGDYyRyLAEVAtG
0 1 T139-p RyLAEVAtGEkRATV
0 4 K142-ac AEVAtGEkRATVVES
0 23 K142-ub AEVAtGEkRATVVES
0 1 K142-sc AEVAtGEkRATVVES
0 1 K152-ac TVVESSEkAYsEAHE
0 24 K152-ub TVVESSEkAYsEAHE
0 1 S155-p ESSEkAYsEAHEISk
0 1 K162-ac sEAHEISkEHMQPtH
0 4 K162 sEAHEISKEHMQPtH
0 2 T168-p SkEHMQPtHPIRLGL
0 9 Y179-p RLGLALNysVFYYEI
0 1 S180-p LGLALNysVFYYEIQ
0 1 K198-ub EQACHLAktAFDDAI
0 1 T199-p QACHLAktAFDDAIA
0 2 Y216-p DTLNEDSyKDSTLIM
0 1 T234-p RDNLTLWtsDQQDDD
0 3 S235-p DNLTLWtsDQQDDDG
  mouse

 
K10-ub DREQLVQkARLAEQA
Y20 LAEQAERYDDMAAAM
K28-ub DDMAAAMkNVTELNE
T31 AAAMkNVTELNEPLs
S38-p TELNEPLsNEERNLL
S46-p NEERNLLsVAykNVV
Y49-p RNLLsVAykNVVGAR
K50-ac NLLsVAykNVVGARR
K50-ub NLLsVAykNVVGARR
S59-p VVGARRSsWRVISsI
S65-p SsWRVISsIEQkTsA
K69-ac VISsIEQkTsADGNE
K69-ub VISsIEQkTsADGNE
S71-p SsIEQkTsADGNEkk
K77-ub TsADGNEkkIEMVRA
K78-ac sADGNEkkIEMVRAY
K88-ac MVRAYREkIEkELEA
K91-ac AYREkIEkELEAVCQ
K110 LLDNYLIKNCsETQy
S113-p NYLIKNCsETQyEsk
T115 LIKNCsETQyEskVF
Y117-p KNCsETQyEskVFYL
S119-p CsETQyEskVFYLkM
K120 sETQyEsKVFYLkMk
K120-ub sETQyEskVFYLkMk
K120 sETQyEsKVFYLkMk
K125-ac EskVFYLkMkGDYyR
K125-ub EskVFYLkMkGDYyR
K127-ub kVFYLkMkGDYyRyL
Y131-p LkMkGDYyRyLAEVA
Y133-p MkGDYyRyLAEVATG
T139 RyLAEVATGEkRATV
K142-ac AEVATGEkRATVVES
K142-ub AEVATGEkRATVVES
K142 AEVATGEKRATVVES
K152 TVVESSEKAYSEAHE
K152-ub TVVESSEkAYSEAHE
S155 ESSEkAYSEAHEISk
K162-ac SEAHEISkEHMQPTH
K162-ub SEAHEISkEHMQPTH
T168 SkEHMQPTHPIRLGL
Y179 RLGLALNYSVFYYEI
S180 LGLALNYSVFYYEIQ
K198 EQACHLAKTAFDDAI
T199 QACHLAKTAFDDAIA
Y216 DTLNEDSYKDSTLIM
T234 RDNLTLWTsDQQDDD
S235-p DNLTLWTsDQQDDDG
  rat

 
K10-ub DREQLVQkARLAEQA
Y20-p LAEQAERyDDMAAAM
K28 DDMAAAMKNVTELNE
T31 AAAMKNVTELNEPLS
S38 TELNEPLSNEERNLL
S46-p NEERNLLsVAYkNVV
Y49 RNLLsVAYkNVVGAR
K50-ac NLLsVAYkNVVGARR
K50-ub NLLsVAYkNVVGARR
S59 VVGARRSSWRVISSI
S65 SSWRVISSIEQkTSA
K69-ac VISSIEQkTSADGNE
K69-ub VISSIEQkTSADGNE
S71 SSIEQkTSADGNEkk
K77-ub TSADGNEkkIEMVRA
K78-ac SADGNEkkIEMVRAY
K88 MVRAYREKIEKELEA
K91 AYREKIEKELEAVCQ
K110 LLDNYLIKNCSETQy
S113 NYLIKNCSETQyESk
T115 LIKNCSETQyESkVF
Y117-p KNCSETQyESkVFYL
S119 CSETQyESkVFYLkM
K120 SETQyESKVFYLkMk
K120-ub SETQyESkVFYLkMk
K120 SETQyESKVFYLkMk
K125-ac ESkVFYLkMkGDYYR
K125-ub ESkVFYLkMkGDYYR
K127-ub kVFYLkMkGDYYRyL
Y131 LkMkGDYYRyLAEVA
Y133-p MkGDYYRyLAEVATG
T139 RyLAEVATGEkRATV
K142-ac AEVATGEkRATVVES
K142-ub AEVATGEkRATVVES
K142 AEVATGEKRATVVES
K152-ac TVVESSEkAYSEAHE
K152 TVVESSEKAYSEAHE
S155 ESSEkAYSEAHEISk
K162-ac SEAHEISkEHMQPTH
K162-ub SEAHEISkEHMQPTH
T168 SkEHMQPTHPIRLGL
Y179 RLGLALNYSVFYYEI
S180 LGLALNYSVFYYEIQ
K198 EQACHLAKTAFDDAI
T199 QACHLAKTAFDDAIA
Y216 DTLNEDSYKDSTLIM
T234 RDNLTLWTSDQQDDD
S235 DNLTLWTSDQQDDDG
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