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Protein Page:
CDC20 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDC20 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2. Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Cell cycle regulation
Cellular Component: nucleoplasm; spindle pole; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; nucleolus; spindle; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein binding; enzyme binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of dendrite development; positive regulation of synaptic plasticity; regulation of meiosis; protein ubiquitination; cell cycle; anaphase-promoting complex activation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; positive regulation of cell proliferation; mitotic cell cycle
Reference #:  Q12834 (UniProtKB)
Alt. Names/Synonyms: bA276H19.3; CDC20; CDC20 cell division cycle 20 homolog; CDC20A; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; MGC102824; p55CDC
Gene Symbols: CDC20
Molecular weight: 54,723 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDC20

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 14 S41-p EAAGPAPsPMRAANR
0 1 S49-p PMRAANRsHsAGRtP
1 2 S51-p RAANRsHsAGRtPGR
0 2 T55-p RsHsAGRtPGRtPGk
0 2 T59-p AGRtPGRtPGkSSSk
0 1 K62-ub tPGRtPGkSSSkVQt
0 1 K66-ub tPGkSSSkVQttPsk
0 1 T69-p kSSSkVQttPskPGG
0 9 T70-p SSSkVQttPskPGGD
1 3 S72-p SkVQttPskPGGDRy
0 1 K73-ub kVQttPskPGGDRyI
0 3 Y79-p skPGGDRyIPHRSAA
0 6 A86 yIPHRSAAQMEVAsF
1 2 S92-p AAQMEVAsFLLSkEN
0 1 K97-ub VAsFLLSkENQPENS
0 7 T106-p NQPENSQtPTkKEHQ
0 1 K109-ub ENSQtPTkKEHQkAW
0 1 K114-ub PTkKEHQkAWALNLN
0 1 K129-ub GFDVEEAkILRLsGk
0 1 S134-p EAkILRLsGkPQNAP
0 2 K136-ub kILRLsGkPQNAPEG
0 4 Y152-p QNRLKVLysQkAtPG
2 1 S153-p NRLKVLysQkAtPGs
0 1 K155-ub LKVLysQkAtPGssR
1 4 T157-p VLysQkAtPGssRKt
0 1 S160-p sQkAtPGssRKtCRY
1 1 S161-p QkAtPGssRKtCRYI
0 1 T164-p tPGssRKtCRYIPsL
1 1 S170-p KtCRYIPsLPDRILD
0 6 K259-ub LWDVQQQkRLRNMTS
0 1 K435-ub WKYPTMAkVAELkGH
0 1 K440-ub MAkVAELkGHTSRVL
0 2 S448-p GHTSRVLsLTMSPDG
0 1 S452 RVLsLTMSPDGAtVA
0 2 T457-p TMSPDGAtVASAAAD
0 2 T466-p ASAAADEtLRLWRCF
0 3 K485-ub ARRREREkASAAkSS
0 6 K490-ub REkASAAkSSLIHQG
8038 : Phospho-CDC20 (Ser51) Antibody
  mouse

 
S41-p EATGPAPsPMRAANR
S49 PMRAANRSHSAGRTP
S51 RAANRSHSAGRTPGR
T55 RSHSAGRTPGRTPGK
T59 AGRTPGRTPGKSSSK
K62 TPGRTPGKSSSKVQT
K66 TPGKSSSKVQTtPSK
T69 KSSSKVQTtPSKPGG
T70-p SSSKVQTtPSKPGGD
S72 SKVQTtPSKPGGDRF
K73 KVQTtPSKPGGDRFI
F79 SKPGGDRFIPQRSAs
S86-p FIPQRSAsQMEVASF
S92 AsQMEVASFLLSKEN
K97 VASFLLSKENQPEDR
T106-p NQPEDRGtPTKKEHQ
K109 EDRGtPTKKEHQKAW
K114 PTKKEHQKAWSLNLN
K129 GFDVEEAKILRLSGk
S134 EAKILRLSGkPQNAP
K136-ub KILRLSGkPQNAPEG
Y152 QNRLKVLYSQKATPG
S153 NRLKVLYSQKATPGS
K155 LKVLYSQKATPGSSR
T157 VLYSQKATPGSSRKT
S160 SQKATPGSSRKTCRY
S161 QKATPGSSRKTCRYI
T164 TPGSSRKTCRYIPSL
S170 KTCRYIPSLPDRILD
K259 LWDVQQQKRLRNMTS
K435 WKYPTMAKVAELKGH
K440 MAKVAELKGHTARVL
G448 GHTARVLGLTMsPDG
S452-p RVLGLTMsPDGATVA
T457 TMsPDGATVASAAAD
T466 ASAAADETLRLWRCF
K485 ALRREREKASVAkSS
K490-ub REKASVAkSSLIHQG
8038 : Phospho-CDC20 (Ser51) Antibody
  rat

 
S41 EATGPAPSPMRAANR
S49 PMRAANRSHsAGRTP
S51-p RAANRSHsAGRTPGR
T55 RSHsAGRTPGRTPGK
T59 AGRTPGRTPGKSNSK
K62 TPGRTPGKSNSKVQT
K66 TPGKSNSKVQTTPSK
T69 KSNSKVQTTPSKPGG
T70 SNSKVQTTPSKPGGD
S72 SKVQTTPSKPGGDRY
K73 KVQTTPSKPGGDRYI
Y79 SKPGGDRYIPQRSAS
S86 YIPQRSASQMEVASF
S92 ASQMEVASFLLSKEN
K97 VASFLLSKENQPEDG
T106 NQPEDGGTPTKKEHQ
K109 EDGGTPTKKEHQKAW
K114 PTKKEHQKAWARNLN
K129 GFDVEEAKILRLSGK
S134 EAKILRLSGKPQNAP
K136 KILRLSGKPQNAPEG
Y152 QNRLKVLYSQKATPG
S153 NRLKVLYSQKATPGS
K155 LKVLYSQKATPGSSR
T157 VLYSQKATPGSSRKA
S160 SQKATPGSSRKACRY
S161 QKATPGSSRKACRYI
A164 TPGSSRKACRYIPSL
S170 KACRYIPSLPDRILD
K259 LWDVQQQKRLRNMTS
K435 WKYPTMAKVAELKGH
K440 MAKVAELKGHTARVL
S448 GHTARVLSLTMSPDG
S452 RVLSLTMSPDGATVA
T457 TMSPDGATVASAAAD
T466 ASAAADETLRLWRCF
K485 ALRREREKASTSKSS
K490 REKASTSKSSLIHQG
8038 : Phospho-CDC20 (Ser51) Antibody
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