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Cdc20 (human)

Overview Cdc20 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2. Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: nucleoplasm; spindle pole; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; spindle; cytosol Molecular Function: protein C-terminus binding; protein binding; enzyme binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of synaptic plasticity; regulation of meiosis; regulation of dendrite development; protein ubiquitination; cell cycle; M phase of mitotic cell cycle; anaphase-promoting complex activation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; positive regulation of cell proliferation; mitotic cell cycle; cell cycle checkpoint; mitotic prometaphase Reference #:  Q12834 (UniProtKB) Alt. Names/Synonyms: bA276H19.3; CDC20; CDC20 cell division cycle 20 homolog; CDC20A; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; MGC102824; p55CDC Gene Symbols: CDC20 Molecular weight: 54,723 Da Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Cdc20 4GGA - A=81-499 (human) 4GGC - A=161-477 (human) 4GGD - D/C=20-42 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	11		S41-p	EAAGPAPsPMRAANR
0	1		S49-p	PMRAANRsHsAGRtP
1	1		S51-p	RAANRsHsAGRtPGR
0	1		T55-p	RsHsAGRtPGRtPGk
0	1		T59-p	AGRtPGRtPGkSSSk
0	1		K62-u	tPGRtPGkSSSkVQt
0	1		K66-u	tPGkSSSkVQttPsk
0	1		T69-p	kSSSkVQttPskPGG
0	7		T70-p	SSSkVQttPskPGGD
1	2		S72-p	SkVQttPskPGGDRy
0	1		K73-u	kVQttPskPGGDRyI
0	3		Y79-p	skPGGDRyIPHRSAA
0	6		A86	yIPHRSAAQMEVAsF
1	2		S92-p	AAQMEVAsFLLSkEN
0	1		K97-u	VAsFLLSkENQPENS
0	6		T106-p	NQPENSQtPTkKEHQ
0	1		K109-u	ENSQtPTkKEHQkAW
0	1		K114-u	PTkKEHQkAWALNLN
0	1		K129-u	GFDVEEAkILRLSGk
0	2		K136-u	kILRLSGkPQNAPEG
0	3		Y152-p	QNRLKVLysQkAtPG
2	1		S153-p	NRLKVLysQkAtPGS
0	1		K155-u	LKVLysQkAtPGSsR
1	2		T157-p	VLysQkAtPGSsRKt
1	1		S161-p	QkAtPGSsRKtCRYI
0	1		T164-p	tPGSsRKtCRYIPsL
0	1		S170-p	KtCRYIPsLPDRILD
0	6		K259-u	LWDVQQQkRLRNMTS
0	1		K435-u	WKYPTMAkVAELkGH
0	1		K440-u	MAkVAELkGHTSRVL
0	2		S448-p	GHTSRVLsLTMSPDG
0	1		S452	RVLsLTMSPDGAtVA
0	2		T457-p	TMSPDGAtVASAAAD
0	2		T466-p	ASAAADEtLRLWRCF
0	3		K485-u	ARRREREkASAAkSS
0	6		K490-u	REkASAAkSSLIHQG

	mouse
S41-p	EATGPAPsPMRAANR
S49	PMRAANRSHSAGRTP
S51	RAANRSHSAGRTPGR
T55	RSHSAGRTPGRTPGK
T59	AGRTPGRTPGKSSSK
K62	TPGRTPGKSSSKVQT
K66	TPGKSSSKVQTTPSK
T69	KSSSKVQTTPSKPGG
T70	SSSKVQTTPSKPGGD
S72	SKVQTTPSKPGGDRF
K73	KVQTTPSKPGGDRFI
F79	SKPGGDRFIPQRSAs
S86-p	FIPQRSAsQMEVASF
S92	AsQMEVASFLLSKEN
K97	VASFLLSKENQPEDR
T106-p	NQPEDRGtPTKKEHQ
K109	EDRGtPTKKEHQKAW
K114	PTKKEHQKAWSLNLN
K129	GFDVEEAKILRLSGk
K136-u	KILRLSGkPQNAPEG
Y152	QNRLKVLYSQKATPG
S153	NRLKVLYSQKATPGS
K155	LKVLYSQKATPGSSR
T157	VLYSQKATPGSSRKT
S161	QKATPGSSRKTCRYI
T164	TPGSSRKTCRYIPSL
S170	KTCRYIPSLPDRILD
K259	LWDVQQQKRLRNMTS
K435	WKYPTMAKVAELKGH
K440	MAKVAELKGHTARVL
G448	GHTARVLGLTMsPDG
S452-p	RVLGLTMsPDGATVA
T457	TMsPDGATVASAAAD
T466	ASAAADETLRLWRCF
K485	ALRREREKASVAkSS
K490-u	REKASVAkSSLIHQG

	rat
S41	EATGPAPSPMRAANR
S49	PMRAANRSHsAGRTP
S51-p	RAANRSHsAGRTPGR
T55	RSHsAGRTPGRTPGK
T59	AGRTPGRTPGKSNSK
K62	TPGRTPGKSNSKVQT
K66	TPGKSNSKVQTTPSK
T69	KSNSKVQTTPSKPGG
T70	SNSKVQTTPSKPGGD
S72	SKVQTTPSKPGGDRY
K73	KVQTTPSKPGGDRYI
Y79	SKPGGDRYIPQRSAS
S86	YIPQRSASQMEVASF
S92	ASQMEVASFLLSKEN
K97	VASFLLSKENQPEDG
T106	NQPEDGGTPTKKEHQ
K109	EDGGTPTKKEHQKAW
K114	PTKKEHQKAWARNLN
K129	GFDVEEAKILRLSGK
K136	KILRLSGKPQNAPEG
Y152	QNRLKVLYSQKATPG
S153	NRLKVLYSQKATPGS
K155	LKVLYSQKATPGSSR
T157	VLYSQKATPGSSRKA
S161	QKATPGSSRKACRYI
A164	TPGSSRKACRYIPSL
S170	KACRYIPSLPDRILD
K259	LWDVQQQKRLRNMTS
K435	WKYPTMAKVAELKGH
K440	MAKVAELKGHTARVL
S448	GHTARVLSLTMSPDG
S452	RVLSLTMSPDGATVA
T457	TMSPDGATVASAAAD
T466	ASAAADETLRLWRCF
K485	ALRREREKASTSKSS
K490	REKASTSKSSLIHQG

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