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Protein Page:
STAM1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
STAM1 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: early endosome membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; intracellular protein transport; positive regulation of signal transduction; signal transduction; endosome transport
Reference #:  Q92783 (UniProtKB)
Alt. Names/Synonyms: DKFZp686J2352; HSE1 homolog; Signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM; STAM-1; STAM1
Gene Symbols: STAM
Molecular weight: 59,180 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 18 K154-u SQAAEQAkAsPALVA
0 1 S91 VCSRDFASEVSNVLN
0 2 K133-u SLISAMIkNLKEQGV
0 1 K136 SAMIkNLKEQGVTFP
0 5 S156-p AAEQAkAsPALVAkD
0 11 K162-u AsPALVAkDPGTVAN
0 13 K170-u DPGTVANkkEEEDLA
0 5 K171-u PGTVANkkEEEDLAK
0 5 K185-u KAIELSLkEQRQQST
0 23 Y198-p STTLSTLyPSTsSLL
0 2 S202-p STLyPSTsSLLTNHQ
0 2 K276-u TAEPEMIkTEKKTVQ
0 207 Y381-p LMNEDPMysMyAKLQ
0 13 S382-p MNEDPMysMyAKLQN
0 259 Y384-p EDPMysMyAKLQNQP
  mouse

 
K154-u SQAAEQAkAsPALVA
S91-p VCSRDFAsEVSNVLN
K133-u SLISAMIkNLkEQGV
K136-u SAMIkNLkEQGVTFP
S156-p AAEQAkAsPALVAkD
K162-u AsPALVAkDPGTVAT
K170 DPGTVATKkEEEDLA
K171-u PGTVATKkEEEDLAK
K185-u KAIELSLkEQRQQSA
Y198-p SAPVSTLyPSTSNLL
S202 STLyPSTSNLLTNHQ
K276-u TAEPEMIkTEKKTVQ
Y381-p LMNEDPMySMyAKLQ
S382 MNEDPMySMyAKLQS
Y384-p EDPMySMyAKLQSQQ
  rat

 
K154 SQAAEQAKASPALVA
S91 VCSRDFASEVSNVLN
K133 SLISAMIKNLKEQGV
K136 SAMIKNLKEQGVTFP
S156 AAEQAKASPALVAKD
K162 ASPALVAKDPGTVAT
K170 DPGTVATKKEEEDLA
K171 PGTVATKKEEEDLAK
K185-u KAIELSLkEQRQQAA
Y198 AAPLSTLYPSTSSLL
S202 STLYPSTSSLLTNHQ
K276 TAEPEMIKTEKKTVQ
Y383 LMNEDPVYSVYAKSQ
S384 MNEDPVYSVYAKSQS
Y386 EDPVYSVYAKSQSQQ
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