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Protein Page:
STAM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAM1 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: early endosome membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; intracellular protein transport; positive regulation of signal transduction; endosome transport; signal transduction
Reference #:  Q92783 (UniProtKB)
Alt. Names/Synonyms: DKFZp686J2352; HSE1 homolog; Signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM; STAM-1; STAM1
Gene Symbols: STAM
Molecular weight: 59,180 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S91-p VCSRDFAsEVSNVLN
0 2 K133-ub SLISAMIkNLKEQGV
0 1 K136 SAMIkNLKEQGVTFP
0 18 K154-ub SQAAEQAkAsPALVA
0 6 S156-p AAEQAkAsPALVAkD
0 11 K162-ub AsPALVAkDPGTVAN
0 13 K170-ub DPGTVANkkEEEDLA
0 5 K171-ub PGTVANkkEEEDLAk
0 1 K178-ub kEEEDLAkAIELSLk
0 5 K185-ub kAIELSLkEQRQQST
0 2 T196-p QQSTTLStLyPsTss
0 24 Y198-p STTLStLyPsTssLL
0 1 S200-p TLStLyPsTssLLtN
0 2 S202-p StLyPsTssLLtNHQ
0 1 S203-p tLyPsTssLLtNHQH
0 1 T206-p PsTssLLtNHQHEGR
0 2 K276-ub TAEPEMIkTEKKTVQ
0 1 Y371-p VMEALSLytKLMNED
0 1 T372-p MEALSLytKLMNEDP
0 181 Y381-p LMNEDPMysMyAKLQ
0 13 S382-p MNEDPMysMyAKLQN
0 243 Y384-p EDPMysMyAKLQNQP
  mouse

 
S91-p VCSRDFAsEVSNVLN
K133-ub SLISAMIkNLkEQGV
K136-ub SAMIkNLkEQGVTFP
K154-ub SQAAEQAkAsPALVA
S156-p AAEQAkAsPALVAkD
K162-ub AsPALVAkDPGTVAT
K170 DPGTVATKkEEEDLA
K171-ub PGTVATKkEEEDLAK
K178 kEEEDLAKAIELSLk
K185-ub KAIELSLkEQRQQSA
T196 QQSAPVSTLyPSTSN
Y198-p SAPVSTLyPSTSNLL
S200 PVSTLyPSTSNLLTN
S202 STLyPSTSNLLTNHQ
N203 TLyPSTSNLLTNHQH
T206 PSTSNLLTNHQHEGR
K276-ub TAEPEMIkTEKKTVQ
Y371 VMEALSLYTKLMNED
T372 MEALSLYTKLMNEDP
Y381-p LMNEDPMySMyAKLQ
S382 MNEDPMySMyAKLQS
Y384-p EDPMySMyAKLQSQQ
  rat

 
S91 VCSRDFASEVSNVLN
K133 SLISAMIKNLKEQGV
K136 SAMIKNLKEQGVTFP
K154 SQAAEQAKASPALVA
S156 AAEQAKASPALVAKD
K162 ASPALVAKDPGTVAT
K170 DPGTVATKKEEEDLA
K171 PGTVATKKEEEDLAK
K178 KEEEDLAKAIELSLk
K185-ub KAIELSLkEQRQQAA
T196 QQAAPLSTLYPSTSS
Y198 AAPLSTLYPSTSSLL
S200 PLSTLYPSTSSLLTN
S202 STLYPSTSSLLTNHQ
S203 TLYPSTSSLLTNHQH
T206 PSTSSLLTNHQHEGR
K276 TAEPEMIKTEKKTVQ
Y373 VMEALSLYTKLMNED
T374 MEALSLYTKLMNEDP
Y383 LMNEDPVYSVYAKSQ
S384 MNEDPVYSVYAKSQS
Y386 EDPVYSVYAKSQSQQ
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