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Protein Page:
SLC20A2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC20A2 Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. Defects in SLC20A2 are the cause of basal ganglia calcification, idiopathic, type 3 (IBGC3). An autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: membrane; integral to plasma membrane; plasma membrane
Molecular Function: viral receptor activity; receptor activity; sodium:phosphate symporter activity; inorganic phosphate transmembrane transporter activity
Biological Process: viral reproduction; transport; response to virus; ion transport; transmembrane transport
Reference #:  Q08357 (UniProtKB)
Alt. Names/Synonyms: Gibbon ape leukemia virus receptor 2; GLVR-2; GLVR2; hPit2; MLVAR; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PiT-2; PIT2; S20A2; SLC20A2; Sodium-dependent phosphate transporter 2; solute carrier family 20 (phosphate transporter), member 2; Solute carrier family 20 member 2
Gene Symbols: SLC20A2
Molecular weight: 70,392 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below

SLC20A2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y187 LRALPVFYAATIAIN
0 1 T190 LPVFYAATIAINVFS
0 1 S197 TIAINVFSIMYTGAP
0 1 K248 KITGKLQKEGALsRV
0 3 S253-p LQKEGALsRVsDEsL
0 17 S256-p EGALsRVsDEsLSkV
0 13 S259-p LsRVsDEsLSkVQEA
0 1 K262-ub VsDEsLSkVQEAEsP
0 9 S268-p SkVQEAEsPVFkELP
0 2 K272-ub EAEsPVFkELPGAkA
0 2 K278-ub FkELPGAkANDDSTI
0 11 S316-p AAYGRALsMtHGsVK
0 1 T318-p YGRALsMtHGsVKsP
0 2 S321-p ALsMtHGsVKsPISN
0 6 S324-p MtHGsVKsPISNGtF
0 1 T330-p KsPISNGtFGFDGHT
0 39 Y344-p TRSDGHVyHtVHKDS
0 5 T346-p SDGHVyHtVHKDSGL
0 1 S351 yHtVHKDSGLyKDLL
0 42 Y354-p VHKDSGLyKDLLHkI
0 2 K360-ub LyKDLLHkIHIDRGP
0 3 P367 kIHIDRGPEEkPAQE
0 2 K370-ub IDRGPEEkPAQEsNy
0 1 A372 RGPEEkPAQEsNyRL
0 7 S375-p EEkPAQEsNyRLLRR
0 114 Y377-p kPAQEsNyRLLRRNN
0 47 S385-p RLLRRNNsyTCytAA
0 10 Y386-p LLRRNNsyTCytAAI
0 2 Y389-p RNNsyTCytAAICGL
0 2 T390-p NNsyTCytAAICGLP
0 2 T401-p CGLPVHAtFRAADSS
0 1 S408 tFRAADSSAPEDSEk
0 2 K415-ub SAPEDSEkLVGDTVs
0 1 T420 SEkLVGDTVsyskkR
0 7 S422-p kLVGDTVsyskkRLR
0 6 Y423-p LVGDTVsyskkRLRY
0 5 S424-p VGDTVsyskkRLRYD
0 1 K425-m1 GDTVsyskkRLRYDs
0 2 K425-ub GDTVsyskkRLRYDs
0 1 K426-m1 DTVsyskkRLRYDsy
0 19 S432-p kkRLRYDsyssYCNA
0 10 Y433-p kRLRYDsyssYCNAV
0 7 S434-p RLRYDsyssYCNAVA
0 9 S435-p LRYDsyssYCNAVAE
0 3 Y436 RYDsyssYCNAVAEA
0 1 S458-p GVEMKLAsELADPDQ
0 1 Y646-p AVMALLMyGILPyV_
0 1 Y651-p LMyGILPyV______
  mouse

 
Y187-p LQALPLFyAAtIAIN
T190-p LPLFyAAtIAINVFs
S197-p tIAINVFsIMYTGAP
K248-ub KIAGRLEkESALSRA
S253 LEkESALSRAsDEsL
S256-p ESALSRAsDEsLRKV
S259-p LSRAsDEsLRKVQEA
K262 AsDEsLRKVQEAEsP
S268-p RKVQEAEsPGFKELP
K272 EAEsPGFKELPGAkP
K278-ub FKELPGAkPSDDSAV
S316-p ASYGRALsMTHGsAK
T318 YGRALsMTHGsAKsP
S321-p ALsMTHGsAKsPISN
S324-p MTHGsAKsPISNGTF
T330 KsPISNGTFGFEGHM
Y344-p MRNDGHVyHtVHKDs
T346-p NDGHVyHtVHKDsGL
S351-p yHtVHKDsGLYKDLL
Y354 VHKDsGLYKDLLHkI
K360-ub LYKDLLHkIHVDRGs
S367-p kIHVDRGsEEkPtQE
K370-ub VDRGsEEkPtQENNy
T372-p RGsEEkPtQENNyRL
N375 EEkPtQENNyRLLRR
Y377-p kPtQENNyRLLRRNN
S385-p RLLRRNNsyTCytAA
Y386-p LLRRNNsyTCytAAI
Y389-p RNNsyTCytAAICGM
T390-p NNsyTCytAAICGMP
T401 CGMPVHTTFRASDTS
S409-p FRASDTSsAPEDSEk
K416-ub sAPEDSEkLVGDsVs
S421-p SEkLVGDsVsYskKR
S423-p kLVGDsVsYskKRLR
Y424 LVGDsVsYskKRLRY
S425-p VGDsVsYskKRLRYD
K426 GDsVsYsKKRLRYDs
K426-ub GDsVsYskKRLRYDs
K427 DsVsYskKRLRYDsy
S433-p kKRLRYDsyssyCNA
Y434-p KRLRYDsyssyCNAV
S435-p RLRYDsyssyCNAVA
S436-p LRYDsyssyCNAVAE
Y437-p RYDsyssyCNAVAEA
S459 GVEMRLASELADPDR
Y647 AIMALLMYICGLFSS
- gap
  rat

 
Y187 LQALPLFYAATIAIN
T190 LPLFYAATIAINVFS
S197 TIAINVFSIMYTGAP
K248 KIAGRLEKESALsRA
S253-p LEKESALsRAsDEsL
S256-p ESALsRAsDEsLRKV
S259-p LsRAsDEsLRKVQEA
K262 AsDEsLRKVQEAESP
S268 RKVQEAESPVFKELP
K272 EAESPVFKELPGAKA
K278 FKELPGAKASDDSAV
S316 ASYGRALSMTHGSAK
T318 YGRALSMTHGSAKSP
S321 ALSMTHGSAKSPISN
S324 MTHGSAKSPISNGTF
T330 KSPISNGTFGFEGHM
Y344 MRNDGHVYHTVHKDS
T346 NDGHVYHTVHKDSGL
S351 YHTVHKDSGLYKDLL
Y354 VHKDSGLYKDLLHKI
K360 LYKDLLHKIHVDKGP
P367 KIHVDKGPEEKPAQE
K370 VDKGPEEKPAQENNy
A372 KGPEEKPAQENNyRL
N375 EEKPAQENNyRLLRR
Y377-p KPAQENNyRLLRRNN
S385 RLLRRNNSYTCYTAA
Y386 LLRRNNSYTCYTAAI
Y389 RNNSYTCYTAAICGM
T390 NNSYTCYTAAICGMP
T401 CGMPVHATFRASDTS
S409 FRASDTSSAPEDSEK
K416 SAPEDSEKLVGDTVS
T421 SEKLVGDTVSYSKKR
S423 KLVGDTVSYSKKRLR
Y424 LVGDTVSYSKKRLRY
S425 VGDTVSYSKKRLRYD
K426 GDTVSYSKKRLRYDS
K426 GDTVSYSKKRLRYDS
K427 DTVSYSKKRLRYDSY
S433 KKRLRYDSYSSYCNA
Y434 KRLRYDSYSSYCNAV
S435 RLRYDSYSSYCNAVA
S436 LRYDSYSSYCNAVAE
Y437 RYDSYSSYCNAVAEA
S459 GVEMRLASELTDPDQ
Y647 AIMALLMYICGFVSS
- gap
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