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Protein Page:
TORC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TORC2 the transducer of regulated CREB protein 2 (TORC2) is a cAMP responsive coactivator that, in concert with LKB1 and AMPK, controls glucose homeostasis in the liver. Under fasting conditions, cytoplasmic TORC2 is transported to the nucleus where it binds to CREB and stimulates gluconeogenisis. Re-feeding and the ensuing insulin response inhibits gluconeogenic gene expression by promoting the phosphorylation, cytoplasmic export and degradation of TORC2. TORC2 is phosphorylated by the kinase QIK which in turn is activated by phosphorylation at Ser358 by insulin-activated Akt2. Phosphorylated TORC2 is subsequently ubiquitinylated at Lys 628 and degraded by the 26S proteasome. TORC2 protein levels and activity are increased in diabetes owing to a block in TORC2 phosphorylation, implicating this pathway in the pathogenesis of diabetes. The CREB/TORC2 regulatory axis controls the normal pattern of germinal center (GC) B cell gene activation/repression that promotes B cell development and circumvents GC lymphomagenesis. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; cAMP response element binding protein binding
Biological Process: transcription, DNA-dependent; viral reproduction; activation of CREB transcription factor; glucose homeostasis; protein homotetramerization; gluconeogenesis
Reference #:  Q53ET0 (UniProtKB)
Alt. Names/Synonyms: CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; CRTC2; RP11-422P24.6; TORC-2; TORC2; Transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2
Gene Symbols: CRTC2
Molecular weight: 73,302 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TORC2

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S171‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K25-ac NPRKFSEkIALQKQR
0 1 T37 KQRQAEETAAFEEVM
0 5 S64-p LRLAYTRsSHyGGsL
0 2 Y67-p AYTRsSHyGGsLPNV
1 21 S70-p RsSHyGGsLPNVNQI
1 1 S70 RsSHyGGSLPNVNQI
0 4 S79-p PNVNQIGsGLAEFQs
0 21 S86-p sGLAEFQsPLHsPLD
0 18 S90-p EFQsPLHsPLDsSRS
0 1 S94-p PLHsPLDsSRSTRHH
0 2 S116-p RDPRRMVsPLRRYTR
0 1 Y121 MVsPLRRYTRHIDss
0 2 S127-p RYTRHIDssPysPAy
0 1 S127 RYTRHIDSsPysPAy
0 2 S128-p YTRHIDssPysPAyL
0 1 S128 YTRHIDsSPysPAyL
0 4 Y130-p RHIDssPysPAyLsP
0 11 S131-p HIDssPysPAyLsPP
0 14 Y134-p ssPysPAyLsPPPES
0 50 S136-p PysPAyLsPPPESSW
0 1 S141 yLsPPPESSWRRTMA
0 1 K156-ub WGNFPAEkGQLFrLP
0 1 R161-m2 AEkGQLFrLPsALNR
0 11 S164-p GQLFrLPsALNRtss
0 12 T169-p LPsALNRtssDsALH
0 2 S170-p PsALNRtssDsALHt
12 14 S171-p sALNRtssDsALHtS
1 1 S171 sALNRtsSDsALHtS
0 2 S173-p LNRtssDsALHtSVM
0 1 S173 LNRtssDSALHtSVM
0 1 T177-p ssDsALHtSVMNPsP
0 2 S178 sDsALHtSVMNPsPQ
0 1 S183-p HtSVMNPsPQDtYPG
0 2 T187-p MNPsPQDtYPGPtPP
0 1 T192-p QDtYPGPtPPSILPS
0 2 K228-ac LDDKHLLkPWDAKKL
2 0 S274 PAMNTGGSLPDLTNL
1 1 S306 PSLSGGNSTSNLTHT
0 2 S336-p YDAPGLHsPLSHPsL
0 1 S342-p HsPLSHPsLQSSLsN
0 3 S348-p PsLQSSLsNPNLQAS
2 7 S368-p PQLQGSHsHPSLPAS
0 1 S386-p RHVLPTTsLGHPsLs
0 1 S391-p TTsLGHPsLsAPALs
0 5 S393-p sLGHPsLsAPALssS
0 1 S398-p sLsAPALssSSSSSS
0 1 S399-p LsAPALssSSSSSST
0 1 S419-p GAPSYPAsTPGAsPH
0 1 S424-p PAsTPGAsPHHRRVP
1 91 S433-p HHRRVPLsPLsLLAG
0 4 S436-p RVPLsPLsLLAGPAD
0 7 S447-p GPADARRsQQQLPKQ
0 5 S456-p QQLPKQFsPTMsPTL
0 1 T458 LPKQFsPTMsPTLSS
0 1 S460-p KQFsPTMsPTLSSIT
0 1 T462 FsPTMsPTLSSITQG
0 6 Y488-p QRLPPYPyssPsLVL
0 11 S489-p RLPPYPyssPsLVLP
0 4 S490-p LPPYPyssPsLVLPt
0 13 S492-p PYPyssPsLVLPtQP
0 3 T497-p sPsLVLPtQPHtPKS
0 14 T501-p VLPtQPHtPKSLQQP
0 1 S519-p SQSCSVQsSGGQPPG
0 20 S613-p THCSRHGsGPNIILt
0 2 T620-p sGPNIILtGDssPGF
0 5 S623-p NIILtGDssPGFskE
0 14 S624-p IILtGDssPGFskEI
0 2 S628-p GDssPGFskEIAAAL
1 0 K629-ac DssPGFskEIAAALA
1 0 K629 DssPGFsKEIAAALA
  mouse

 
K25 NPRKFSEKIALQKQR
T37-gl KQRQAEEtAAFEEVM
S64-p LRLAYTRsSHyGGsL
Y67-p AYTRsSHyGGsLPNV
S70-p RsSHyGGsLPNVNQI
S70-gl RsSHyGGsLPNVNQI
C79 PNVNQIGCGLAEFQs
S86-p CGLAEFQsPLHsPLD
S90-p EFQsPLHsPLDSSRS
S94 PLHsPLDSSRSTRHH
S116 RDARRMVSPLRRyPR
Y121-p MVSPLRRyPRHIDss
S127-p RyPRHIDssPySPAY
S127-gl RyPRHIDssPySPAY
S128 yPRHIDsSPySPAYL
S128-gl yPRHIDssPySPAYL
Y130-p RHIDssPySPAYLsP
S131 HIDssPySPAYLsPP
Y134 ssPySPAYLsPPPEs
S136-p PySPAYLsPPPEsGW
S141-p YLsPPPEsGWRRMMP
K156 WGNLPAEKGQLFrLP
R161-m2 AEKGQLFrLPSALNR
S164 GQLFrLPSALNRtSs
T169-p LPSALNRtSsDsALH
S170 PSALNRtSsDsALHT
S171-p SALNRtSsDsALHTs
S171-gl SALNRtSsDsALHTs
S173-p LNRtSsDsALHTsVM
S173-gl LNRtSsDsALHTsVM
T177 SsDsALHTsVMNPNP
S178-p sDsALHTsVMNPNPQ
N183 HTsVMNPNPQDtYPG
T187-p MNPNPQDtYPGPTPP
T192 QDtYPGPTPPSVLPS
K229-ac VDDKHLLkPWDAKKL
S275-p PAMNTGGsLPDLTNL
S307-p PSLSGGNsTTNLTHT
S337 YDVPGLHSPLSHPSL
S343 HSPLSHPSLQSSLSN
S349 PSLQSSLSNPNLQAS
S369-p PQLQGSHsHPSLPAS
S387 HHALPTTSLGHPSLs
S392 TTSLGHPSLsAPALS
S394-p SLGHPSLsAPALSSS
S399 SLsAPALSSSSSSSS
S400 LsAPALSSSSSSSST
S420 SAPPYPASTPGASPR
S425 PASTPGASPRHRRVP
S434-p RHRRVPLsPLsLPAG
S437-p RVPLsPLsLPAGPAD
S448 GPADARRSQQQLPKQ
S457-p QQLPKQFsPtMSPtL
T459-p LPKQFsPtMSPtLSS
S461 KQFsPtMSPtLSSIT
T463-p FsPtMSPtLSSITQG
Y489-p QRLPPYPysPPsLVI
S490-p RLPPYPysPPsLVIP
P491 LPPYPysPPsLVIPT
S493-p PYPysPPsLVIPTHP
T498 PPsLVIPTHPPtPKS
T502-p VIPTHPPtPKSLQQL
P518 SQACLVQPSGGQPPG
S612-p THCSRHGsGPNIILT
T619 sGPNIILTGDssPGF
S622-p NIILTGDssPGFskE
S623-p IILTGDssPGFskEI
S627-p GDssPGFskEIAAAL
K628-ac DssPGFskEIAAALA
K628-ub DssPGFskEIAAALA
  rat

 
K25 NPRKFSEKIALQKQR
T37 KQRQAEETAAFEEVM
S64 LRLAYTRSSHYGGSL
Y67 AYTRSSHYGGSLPNV
S70 RSSHYGGSLPNVNQI
S70 RSSHYGGSLPNVNQI
C79 PNVNQIGCGLAEFQS
S86 CGLAEFQSPLHSPLD
S90 EFQSPLHSPLDSSRS
S94 PLHSPLDSSRSTRHH
S116 RDPRRMVSPLRRYPR
Y121 MVSPLRRYPRHIDSS
S127 RYPRHIDSSPYSPAY
S127 RYPRHIDSSPYSPAY
S128 YPRHIDSSPYSPAYL
S128 YPRHIDSSPYSPAYL
Y130 RHIDSSPYSPAYLSP
S131 HIDSSPYSPAYLSPP
Y134 SSPYSPAYLSPPPES
S136 PYSPAYLSPPPESGW
S141 YLSPPPESGWRRMMP
K156 WGNLPAEKGQLFRLP
R161 AEKGQLFRLPSALNR
S164 GQLFRLPSALNRTSs
T169 LPSALNRTSsDSALH
S170 PSALNRTSsDSALHT
S171-p SALNRTSsDSALHTS
S171 SALNRTSSDSALHTS
S173 LNRTSsDSALHTSVM
S173 LNRTSsDSALHTSVM
T177 SsDSALHTSVMNPNP
S178 sDSALHTSVMNPNPQ
N183 HTSVMNPNPQDTYPG
T187 MNPNPQDTYPGPTPP
T192 QDTYPGPTPPSVLPS
K228 VDDKHLLKPWDAKKL
S274 PAMSTGGSLPDLTNL
S306 PSLSGGNSTTNLTHT
S336 YDVPGLHSPLSHPSL
S342 HSPLSHPSLQSSLSN
S348 PSLQSSLSNPNLQAS
S368 PQLQGSHSHPSLPAS
S386 HHALPTTSLGHPSLS
S391 TTSLGHPSLSAPALS
S393 SLGHPSLSAPALSSS
S398 SLSAPALSSSSSSSS
S399 LSAPALSSSSSSSST
S419 SAPPYPASTPGASPR
S424 PASTPGASPRHRRVP
S433 RHRRVPLSPLSLPAG
S436 RVPLSPLSLPAGPAD
S447 GPADARRSQQQLPKQ
S456 QQLPKQFSPTMSPTL
T458 LPKQFSPTMSPTLSS
S460 KQFSPTMSPTLSSIT
T462 FSPTMSPTLSSITQG
Y488 QRLPPYPYSPPSLVI
S489 RLPPYPYSPPSLVIP
P490 LPPYPYSPPSLVIPS
S492 PYPYSPPSLVIPSHP
S497 PPSLVIPSHPPTPKS
T501 VIPSHPPTPKSLQQL
P517 SQACLVQPSGGQPPG
S611-p THCSRHGsGPNIILT
T618 sGPNIILTGDSSPGF
S621 NIILTGDSSPGFSKE
S622 IILTGDSSPGFSKEI
S626 GDSSPGFSKEIAAAL
K627 DSSPGFSKEIAAALA
K627 DSSPGFSKEIAAALA
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