Home

ADAM9 (human)

Overview ADAM9 Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protease; Motility/polarity/chemotaxis; EC 3.4.24.-; Membrane protein, integral Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane Molecular Function: collagen binding; integrin binding; protein binding; protein kinase C binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; laminin binding; SH3 domain binding Biological Process: positive regulation of keratinocyte migration; integrin-mediated signaling pathway; activation of MAPKK activity; cell-matrix adhesion; membrane protein ectodomain proteolysis; response to glucocorticoid stimulus; positive regulation of cell adhesion mediated by integrin; positive regulation of membrane protein ectodomain proteolysis; keratinocyte differentiation; response to manganese ion; PMA-inducible membrane protein ectodomain proteolysis; response to hydrogen peroxide; positive regulation of protein secretion; monocyte activation; transforming growth factor beta receptor signaling pathway; cell-cell adhesion mediated by integrin; cell adhesion mediated by integrin; response to calcium ion; cell adhesion Reference #:  Q13443 (UniProtKB) Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 9 (meltrin gamma); ADAM 9; ADAM metallopeptidase domain 9 (meltrin gamma); ADAM9; Cellular disintegrin-related protein; CORD9; Disintegrin and metalloproteinase domain-containing protein 9; KIAA0021; MCMP; MDC9; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; MLTNG; Myeloma cell metalloproteinase Gene Symbols: ADAM9 Molecular weight: 90,556 Da Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ADAM9 1M1V - A=208-404 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K184-a	VSNKDIEkETAkDEE
0	1		K188-a	DIEkETAkDEEEEPP
0	1		Y213-p	AVLPQTRyVELFIVV
0	1		K533-a	VIFGSKAkAAPKDCF
0	2		T735-p	FRKKRSQtyEsDGkN
0	47		Y736-p	RKKRSQtyEsDGkNQ
0	2		S738-p	KRSQtyEsDGkNQAN
0	9		K741-u	QtyEsDGkNQANPSR
0	1		S752-p	NPSRQPGsVPRHVsP
0	35		S758-p	GsVPRHVsPVtPPRE
0	223		T761-p	PRHVsPVtPPREVPI
0	327		Y769-p	PPREVPIyANRFAVP
0	3		T777-p	ANRFAVPtyAAkQPQ
0	36		Y778-p	NRFAVPtyAAkQPQQ
0	3		K781-u	AVPtyAAkQPQQFPS
0	1		S798-p	PPPQPKVssQGNLIP
0	3		S799-p	PPQPKVssQGNLIPA
0	109		Y815-p	PAPAPPLyssLT___
0	1		S816-p	APAPPLyssLT____
0	5		S817-p	PAPPLyssLT_____

	mouse
K184	VSNRDTEKEGTQGDE
Q188	DTEKEGTQGDEEEHP
Y213	AVLPQTRYVELFIVV
K533	VIFGSKAKAAPRDCF
-	gap
-	gap
S735	RKKRSQMSDGRNQAN
R738	RSQMSDGRNQANVSR
S751	SRQPGDPSISRPPGG
S762	PPGGPNVSRPPGGPG
S771	PPGGPGVSRPPGGPG
H795	VSRPPPGHGNRFPVP
T803	GNRFPVPTYAAKQPA
Y804	NRFPVPTYAAKQPAQ
K807	PVPTYAAKQPAQFPS
S824	PPPQPKISSQGNLIP
S825	PPQPKISSQGNLIPA
Y841-p	PAPAPPLySSLT___
S842	APAPPLySSLT____
S843	PAPPLySSLT_____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.