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Protein Page:
ADAM9 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ADAM9 Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Membrane protein, integral; Protease; Motility/polarity/chemotaxis
Cellular Component: extracellular space; cell surface; basolateral plasma membrane; cytoplasm; integral to membrane
Molecular Function: collagen binding; integrin binding; protein binding; protein kinase C binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; laminin binding; SH3 domain binding
Biological Process: positive regulation of keratinocyte migration; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; activation of MAPKK activity; cell-matrix adhesion; response to glucocorticoid stimulus; membrane protein ectodomain proteolysis; positive regulation of cell adhesion mediated by integrin; positive regulation of membrane protein ectodomain proteolysis; keratinocyte differentiation; response to manganese ion; collagen catabolic process; extracellular matrix disassembly; PMA-inducible membrane protein ectodomain proteolysis; response to hydrogen peroxide; monocyte activation; positive regulation of protein secretion; transforming growth factor beta receptor signaling pathway; cell-cell adhesion mediated by integrin; cell adhesion mediated by integrin; cell adhesion; response to calcium ion
Reference #:  Q13443 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 9 (meltrin gamma); ADAM 9; ADAM metallopeptidase domain 9 (meltrin gamma); ADAM9; Cellular disintegrin-related protein; CORD9; Disintegrin and metalloproteinase domain-containing protein 9; KIAA0021; MCMP; MDC9; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; MLTNG; Myeloma cell metalloproteinase
Gene Symbols: ADAM9
Molecular weight: 90,556 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ADAM9

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y213-p AVLPQTRyVELFIVV
0 2 T735-p FRKKRSQtyEsDGkN
0 47 Y736-p RKKRSQtyEsDGkNQ
0 2 S738-p KRSQtyEsDGkNQAN
0 9 K741-u QtyEsDGkNQANPSR
0 3 S752-p NPSRQPGsVPRHVsP
0 39 S758-p GsVPRHVsPVtPPRE
0 1 S758-gl GsVPRHVsPVtPPRE
0 228 T761-p PRHVsPVtPPREVPI
0 1 T761-gl PRHVsPVtPPREVPI
0 331 Y769-p PPREVPIyANrFAVP
0 1 R772-m1 EVPIyANrFAVPtyA
0 3 T777-p ANrFAVPtyAAkQPQ
0 1 T777-gl ANrFAVPtyAAkQPQ
0 37 Y778-p NrFAVPtyAAkQPQQ
0 3 K781-u AVPtyAAkQPQQFPS
0 1 S798-p PPPQPKVssQGNLIP
0 3 S799-p PPQPKVssQGNLIPA
0 110 Y815-p PAPAPPLySsLT___
0 5 S817-p PAPPLySsLT_____
  mouse

 
Y213 AVLPQTRYVELFIVV
- gap
- gap
S735 RKKRSQMSDGRNQAN
R738 RSQMSDGRNQANVSR
S751 SRQPGDPSISRPPGG
S762 PPGGPNVSRPPGGPG
S762 PPGGPNVSRPPGGPG
S771 PPGGPGVSRPPGGPG
S771 PPGGPGVSRPPGGPG
H795 VSRPPPGHGNRFPVP
R798 PPPGHGNRFPVPTYA
T803 GNRFPVPTYAAKQPA
T803 GNRFPVPTYAAKQPA
Y804 NRFPVPTYAAKQPAQ
K807 PVPTYAAKQPAQFPS
S824 PPPQPKISsQGNLIP
S825-p PPQPKISsQGNLIPA
Y841-p PAPAPPLySSLT___
S843 PAPPLySSLT_____
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