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LRP6
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Forms a WNT-signaling complex formed of a WNT protein, a FZD protein and LRP5 or LRP6. Interacts (via the extracellular domain) with WNT1; the interaction is enhanced by prior formation of the Wnt/Fzd complex. Interacts (via the beta-propeller regions 3 and 4) with WNT3A. Interacts (via the beta-propeller regions 1 and 2) with WNT9B. Interacts with FZD5; the interaction forms a coreceptor complex for Wnt signaling and is inhibited by DKK1 and C1orf187. Interacts (via beta propeller region) with DKK1; the interaction inhibits FZD5/LRP6 complex formation. Interacts with DKK2. Interacts with C1orf187/DRAXIN; the interaction inhibits Wnt signaling. Interacts (via the phosphorylated PPPSP motifs) with AXIN1; the interaction recruits the AXIN1/GSK3B complex to cell surface LRP6 signalsomes. Interacts with GRB10; the interaction prevents AXIN1 binding, thus negatively regulating the Wnt signaling pathway. Interacts (via the extracellular domain) with RSPO1; the interaction activates Wnt/beta-catenin signaling. Interacts (via the extracellular domain) with RSPO3 (via the cysteine rich domain); the interaction activates Wnt/beta-catenin signaling. Interacts (via the beta- propeller regions 1 and 2) with SOST; the interaction competes with DKK1 for binding for inhibiting beta-catenin signaling. Interacts with MESD; the interaction prevents the formation of LRP6 aggregates and targets LRP6 to the plasma membrane. Interacts (via the cytoplasmic domain) with CSNKIE; the interaction phosphorylates LRP6, binds AXIN1 and inhibits AXIN1/GSK3B-mediated phosphorylation of beta-catenin. Interacts with MACF1. Decreased levels on WNT3A stimulation. Widely co-expressed with LRP5 during embryogenesis and in adult tissues. Belongs to the LDLR family. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, misc.; Membrane protein, integral |
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Cellular Component: cell surface; cell soma; endoplasmic reticulum; early endosome; plasma membrane; integral to membrane; synapse; cytoplasmic vesicle; caveola; receptor complex
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Molecular Function: low-density lipoprotein receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; protein homodimerization activity; kinase inhibitor activity; frizzled binding; toxin transporter activity; apolipoprotein binding; receptor binding
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Biological Process: embryonic forelimb morphogenesis; radial glial cell differentiation in the forebrain; positive regulation of apoptosis; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; cerebellum morphogenesis; thalamus development; palate development; Wnt receptor signaling pathway through beta-catenin; embryonic pattern specification; bone remodeling; embryonic hindlimb morphogenesis; Wnt receptor signaling pathway in forebrain neuroblast division; anterior/posterior pattern formation; synaptic transmission; negative regulation of protein amino acid phosphorylation; convergent extension; response to folic acid; midbrain development; positive regulation of mesenchymal cell proliferation; positive regulation of bone resorption; neural crest cell differentiation; heart looping; cell migration involved in gastrulation; negative regulation of epithelial cell proliferation; embryonic limb morphogenesis; external genitalia morphogenesis; Wnt receptor signaling pathway; neural crest formation; positive regulation of cell cycle; gastrulation with mouth forming second; negative regulation of fat cell differentiation; positive regulation of ossification; odontogenesis of dentine-containing teeth; formation of radial glial scaffolds; cerebral cortex cell migration; embryonic retina morphogenesis in camera-type eye; midbrain-hindbrain boundary development; neural tube closure; negative regulation of protein kinase activity; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; cerebral cortex development; regulation of ossification
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Reference #:
O75581 (UniProtKB)
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| Alt. Names/Synonyms: ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6 |
| Gene Symbols: LRP6 |
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Molecular weight: 180,429 Da
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Basal Isoelectric point: 5.12
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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mTOR Signaling
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Regulation of Microtubule Dynamics
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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