Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
K81 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K81 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: extracellular space; keratin filament
Molecular Function: protein binding; structural molecule activity
Reference #:  Q14533 (UniProtKB)
Alt. Names/Synonyms: ghHb1; ghHKb1; Hair keratin K2.9; hard keratin, type II, 1; Hb-1; HB1; hHAKB2-1; K81; keratin 81; Keratin, hair, basic, 1; Keratin, type II cuticular Hb1; Keratin-81; KRT81; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; Type II hair keratin Hb1; Type-II keratin Kb21
Gene Symbols: KRT81
Molecular weight: 54,928 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below

K81

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S49-p TGGFGSHsVCGGFRA
0 4 K132-ub RFLEQQNkLLETKLQ
0 27 Y282-p IAEIKAQyDDIVTRS
0 6 K300-ub AESWYRSkCEEMkAT
0 7 K305-ub RSkCEEMkATVIRHG
0 7 K319-ub GETLRRTkEEINELN
0 6 K340-ub TAEVENAkCQNSkLE
0 3 K345-ub NAkCQNSkLEAAVAQ
0 7 K367-ub ALSDARCkLAELEGA
0 7 K377-ub ELEGALQkAkQDMAC
0 7 K379-ub EGALQkAkQDMACLI
  mouse

 
S49-p SGGFGSQsVCGAFRS
K132-ub RFLEQQNkLLETKWQ
Y282 VAEIKAQYDDIASRS
K300 AESWYRTKCEEIKAT
K305 RTKCEEIKATVIRHG
R319 GETLRRTREEINELN
K340 TAEIENAKCQNTKLE
K345 NAKCQNTKLEAAVTQ
K367 ALADARCKLAELEGA
K377 ELEGALQKAKQDMAC
K379 EGALQKAKQDMACLL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.