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K81 (human)

Overview K81 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: keratin filament Molecular Function: protein binding; structural molecule activity Reference #:  Q14533 (UniProtKB) Alt. Names/Synonyms: ghHb1; ghHKb1; Hair keratin K2.9; hard keratin, type II, 1; Hb-1; HB1; hHAKB2-1; K81; keratin 81; Keratin, hair, basic, 1; Keratin, type II cuticular Hb1; Keratin-81; KRT81; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; Type II hair keratin Hb1; Type-II keratin Kb21 Gene Symbols: KRT81 Molecular weight: 54,928 Da Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states

Select Structure to View Below K81

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 158000 602153  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S49-p	TGGFGSHsVCGGFRA
0	4		K132-u	RFLEQQNkLLETKLQ
0	28		Y282-p	IAEIKAQyDDIVTRS
0	6		K300-u	AESWYRSkCEEMkAT
0	7		K305-u	RSkCEEMkATVIRHG
0	7		K319-u	GETLRRTkEEINELN
0	6		K340-u	TAEVENAkCQNSkLE
0	3		K345-u	NAkCQNSkLEAAVAQ
0	7		K367-u	ALSDARCkLAELEGA
0	7		K377-u	ELEGALQkAkQDMAC
0	7		K379-u	EGALQkAkQDMACLI

	mouse
S49-p	SGGFGSQsVCGAFRS
K132-u	RFLEQQNkLLETKWQ
Y282	VAEIKAQYDDIASRS
K300	AESWYRTKCEEIKAT
K305	RTKCEEIKATVIRHG
R319	GETLRRTREEINELN
K340	TAEIENAKCQNTKLE
K345	NAKCQNTKLEAAVTQ
K367	ALADARCKLAELEGA
K377	ELEGALQKAKQDMAC
K379	EGALQKAKQDMACLL

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